British Prime Minister David Cameron says he hopes to kick-start an international effort to find a cure or effective treatment for dementia by 2025. At a one-day summit on dementia hosted by the U.K., Cameron declared that discovering a cure or treatment for dementia is "within our grasp." The Group of Eight health and science ministers signed a declaration agreeing to identify "a cure or disease-modifying therapy for dementia" by 2025.
Blood clots play an unexpected role in protecting the body from the deadly effects of bacteria...
For some microbes, the motto for growth is not so much “every cell for itself,” but rather, “all...
Researchers have determined the structure of the rubella virus capsid protein, which is central to the virus's ability to assemble into an infectious particle and to infect humans. Although a successful vaccine is available to protect against rubella virus infection, the discovery could aid efforts to develop vaccines and antiviral drugs to treat related infections.
To learn new motor skills, the brain must be plastic: able to rapidly change the strengths of connections between neurons, forming new patterns that accomplish a particular task. However, if the brain were too plastic, previously learned skills would be lost too easily. A new computational model explains how the brain maintains the balance between plasticity and stability, and how it can learn similar tasks without interference.
Harmless lung cancer? A provocative study found that nearly one in five lung tumors detected on CT scans are probably so slow-growing that they would never cause problems. The analysis suggests the world's No. 1 cause of cancer deaths isn't as lethal as doctors once thought. In the study, these were not false-positives—suspicious results that turn out upon further testing not to be cancer.
Funded by prominent Silicon Valley investors and Microsoft founder Bill Gates, Hampton Creek Foods seeks to disrupt a global egg industry that backers say wastes energy, pollutes the environment, causes disease outbreaks and confines chickens to tiny spaces. The company, which just started selling a mayonnaise made without eggs, is part of a new generation of so-called food-tech ventures that aim to change the way we eat.
As embryonic tissue develops, cells push and pull on each other, and they must do so correctly for the tissue to develop properly. Now scientists at Harvard Univ. have devised the first method to measure these tiny forces in 3-D tissues and living embryos. The method, which involves injecting tiny oil droplets, could lead to new tools to diagnose cancer, hypertension, connective tissue diseases and more.
In one of the biggest advances against leukemia and other blood cancers in many years, doctors are reporting unprecedented success by using gene therapy to transform patients' blood cells into soldiers that seek and destroy cancer. A few patients with one type of leukemia were given this one-time, experimental therapy several years ago and some remain cancer-free today.
Autism spectrum disorder (ASD) is diagnosed when individuals exhibit characteristic behaviors that include repetitive actions, decreased social interactions and impaired communication. Curiously, many individuals with ASD also suffer from gastrointestinal (GI) issues, such as abdominal cramps and constipation. Using the co-occurrence of brain and gut problems in ASD as their guide, researchers are investigating a new therapy.
New findings by Univ. of California, Irvine (UC Irvine) and German chemists about how cataracts form could be used to help prevent the world’s leading cause of blindness, which currently affects nearly 20 million people worldwide. The UC Irvine team explored and identified the structures of the normal proteins and a genetic mutation known to cause cataracts in young children.
A new method to identify previously hidden details about the structures of proteins may speed the process of novel drug design, according to scientists at Rice Univ. A unique combination of computational techniques and experimental data helped Rice theorists predict intermediate configurations of proteins that, until now, have been hard to detect.
A group of Illinois researchers, led by Centennial Chair Prof. of the Dept. of Chemical and Biomolecular Engineering Huimin Zhao, has demonstrated the use of an innovative DNA engineering technique to discover potentially valuable functions hidden within bacterial genomes. Their work was reported in a Nature Communications article.
Scientists at Penn State Univ. have developed a method that enables a more accurate prediction of how ribonucleic acid molecules (RNAs) fold within living cells, shedding new light on how plants, as well as other living organisms, respond to environmental conditions. The advance was made possible by the ability to analyze more than 10,000 RNA molecules in a single cell.
Researchers have identified a protein that causes loss of function in immune cells combating HIV. The scientists report in a paper appearing online in the Journal of Clinical Investigation that the protein, Sprouty-2, is a promising target for future HIV drug development, since disabling it could help restore the cells’ ability to combat the virus that causes AIDS.
Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now scientists report that they have found a way to penetrate the mystery. They have worked out every step in the molecular dance that enables one such transporter to do its job.
Drugs delivered by nanoparticles hold promise for targeted treatment of many diseases, including cancer. However, the particles have to be injected into patients, which has limited their usefulness so far. Now, researchers have developed a new type of nanoparticle that can be delivered orally and absorbed through the digestive tract, allowing patients to simply take a pill instead of receiving injections.
New research from North Carolina State Univ. shows that iron may play a role in preserving ancient tissues within dinosaur fossils, but also may hide them from detection. The finding could open the door to the recovery of more ancient tissues from within fossils.
Researchers have made inroads into tackling a bacterium that plagues hospitals and is highly resistant to most antibiotics. They determined the 3-D structure and likely function of a new protein in this common bacterium that attacks those with compromised immune systems.
A new innovation may help us deal with post-Thanksgiving guilt: Biotechnologists have constructed a genetic regulatory circuit from human components that monitors blood-fat levels. In response to excessive levels, it produces a messenger substance that signals satiety to the body. Tests on obese mice reveal that this helps them to lose weight.
Damage to or theft of technical equipment represents a dramatic financial and scientific loss to researchers. Scientists in Germany decided to find out whether the information content and tone of labels attached to the equipment could reduce the incidence of vandalism. They found that a friendly, personal label reduced the interaction of people with the equipment in comparison with neutral or threatening labels.
The blood stem cells that live in bone marrow are at the top of a complex family tree. Such stem cells split and divide down various pathways that ultimately produce red cells, white cells and platelets. These “daughter” cells must be produced at a rate of about one million per second to constantly replenish the body’s blood supply. Researchers have long wondered what allows these stem cells to persist for decades, until now.
A new study has found that many people who stopped taking cholesterol-lowering statin drugs were also taking an average of three other drugs that interfered with the normal metabolism of the statins. The other drugs can contribute to a common side effect of taking statins—muscle pain—and often led people to discontinue use of a medication that could otherwise help save their life, researchers learned.
A method by Rice Univ. researchers to model the way proteins fold, and sometimes misfold, has revealed branching behavior that may have implications for Alzheimer’s and other aggregation diseases. In an earlier study of the muscle protein titin, Rice chemist Peter Wolynes and his colleagues analyzed the likelihood of misfolding in proteins, in which domains become entangled with like sequences on nearby chains.
Scientists have charted a significant signaling network in a tiny organism that's big in the world of biofuels research. The findings about how a remarkably fast-growing organism conducts its metabolic business bolster scientists' ability to create biofuels using the hardy microbe Synechococcus, which turns sunlight into useful energy.
Viruses can not only cause illnesses in humans, they also infect bacteria. Bacteria protect themselves with a kind of immune system that detects and “chops up” foreign DNA. Scientists have now shown that the dual-RNA guided enzyme Cas9 which is involved in the process has developed independently in various strains of bacteria. This enhances the potential of exploiting the bacterial immune system for genome engineering.
A team of researchers have demonstrated a technique that, by measuring the physical properties of individual cells in body fluids, can diagnose cancer with a high degree of accuracy. The technique, which uses a deformability cytometer to analyze individual cells, could reduce the need for more cumbersome diagnostic procedures and the associated costs, while improving accuracy over current methods.
Biologists at Brown Univ. have found a way to measure the effects of aging by watching the ebb and flow of chromatin, a structure along strands of DNA that either silences or permits gene expression. In several newly published experiments they show that gene silencing via chromatin in fruit flies declines with age.
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