Ian Duncan is a Scotsman with the iron discipline and stamina of a competitive marathoner, triathlete and cross-country skier. As a neuroscientist at the School of Veterinary Medicine at the Univ. of Wisconsin-Madison, he’s applied his tenacity to a rare genetic disorder. Known as Pelizaeus Merzbacher disease or PMD, it’s a devastating neurological condition that, in its most severe form, kills infants weeks after birth.
Researchers report the first crystal structure of the cellular receptor CXCR4 bound to an immune...
The creation of genetically modified and entirely synthetic organisms continues to generate...
It’s not surprising that our memories of highly emotional events, such as 9/11 or the birth of a...
Research combining experimental work and detailed molecular simulations has revealed, for the first time, the complex role that water plays in collagen. The new analysis reveals an important mechanism that had never been observed before: Adding even small amounts of water to, or removing water from, collagen in tendons can generate surprisingly strong forces, as much as 300 times stronger than the forces generated by muscles.
Even in its quietest moments, the brain is never “off.” Instead, while under anesthesia, during slow-wave sleep, or even amid calm wakefulness, the brain’s cortex maintains a cycle of activity and quiet called “up” and “down” states. A new study by Brown Univ. neuroscientists probed deep into this somewhat mysterious cycle in mice, to learn more about how the mammalian brain accomplishes it.
As predicted, this year's flu vaccine is doing a pretty crummy job. It's only 23% effective, primarily because it doesn't include the bug that is making most people sick, according to a government study released today. That's one of the worst performances in the last decade, since U.S. health officials started routinely tracking how well vaccines work. In the best flu seasons, the vaccines were 50 to 60% effective.
Scientists have gained new insight into fragile X syndrome by studying the case of a person without the disorder, but with two of its classic symptoms. In patients with fragile X, a key gene is completely disabled, eliminating a protein that regulates electrical signals in the brain and causing a host of behavioral, neurological and physical symptoms.
More efficient medical treatments could be developed thanks to a new method for triggering the rearrangement of chemical particles. The new method, developed at the Univ. of Warwick, uses two “parent” nanoparticles that are designed to interact only when in proximity to each other and trigger the release of drug molecules contained within both.
A new study from Massachusetts Institute of Technology reveals one reason why people who suffer from chronic inflammatory diseases such as colitis have a higher risk of mutations that cause cancer. The researchers also found that exposure to DNA-damaging chemicals after a bout of inflammation boosts these mutations even more, further increasing cancer risk.
A stem cell capable of regenerating both bone and cartilage has been identified in bone marrow of mice. The cells, called osteochondroreticular (OCR) stem cells, were discovered by tracking a protein expressed by the cells. Using this marker, the researchers found that OCR cells self-renew and generate key bone and cartilage cells, including osteoblasts and chondrocytes.
Beginning with the invention of the first microscope in the late 1500s, scientists have been trying to peer into preserved cells and tissues with ever-greater magnification. The latest generation of so-called “super-resolution” microscopes can see inside cells with resolution better than 250 nm.
Just as the invention of non-stick pans was a boon for chefs, a new type of nanoscale surface that bacteria can’t stick to holds promise for applications in the food processing, medical and even shipping industries. The technology uses an electrochemical process called anodization to create nanoscale pores that change the electrical charge and surface energy of a metal surface.
Autism is a spectrum of closely related disorders diagnosed in patients who exhibit a shared core of symptoms, including delays in learning to communicate and interact socially. Early detection of autism in children is the key for treatments to be most effective and produce the best outcomes. Using advanced 3-D imaging and statistical analysis techniques, researchers identified facial measurements in children with autism.
DNA molecules provide the "source code" for life in humans, plants, animals and some microbes. But now researchers report an initial study showing that the strands can also act as a glue to hold together 3-D-printed materials that could someday be used to grow tissues and organs in the laboratory.
In a laboratory first, Duke Univ. researchers have grown human skeletal muscle that contracts and responds just like native tissue to external stimuli such as electrical pulses, biochemical signals and pharmaceuticals. The laboratory-grown tissue should soon allow researchers to test new drugs and study diseases in functioning human muscle outside of the human body.
New research has identified one of the key cancer-fighting mechanisms for sulforaphane, and suggests that this phytochemical may be able to move beyond cancer prevention and toward therapeutic use for advanced prostate cancer. Scientists said that pharmacologic doses in the form of supplements would be needed for actual therapies, beyond the amount of sulforaphane that would ordinarily be obtained from dietary sources such as broccoli.
A new study from Lund Univ. in Sweden indicates inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain. Researchers have long been aware endogenous retroviruses constitute around 5% of our DNA. For many years, they were considered junk DNA of no real use, a side effect of our evolutionary journey.
Forget about it. Your brain is a memory powerhouse, constantly recording experiences in long-term memory. Those memories help you find your way through the world: Who works the counter each morning at your favorite coffee shop? How do you turn on the headlights of your car? What color is your best friend's house?
Washington State Univ. Spokane scientists have found a brain protein that boosts the healing power of sleep and speeds an animal's recovery from the flu. The research has determined that a brain-specific protein is uniquely involved in sleep responses triggered by the influenza virus in mice. Without the protein, animals develop more severe symptoms of infection and die at higher rates than regular or control mice.
People who have upbeat outlooks on life have significantly better cardiovascular health, suggests a new study that examined associations between optimism and heart health in more than 5,100 adults. Participants’ cardiovascular health was assessed using seven metrics: blood pressure, body mass index, fasting plasma glucose and serum cholesterol levels, dietary intake, physical activity and tobacco use.
Optogenetics, which uses light to control cellular events, is poised to become an important technology in molecular biology and beyond. The Reich Group in Univ. of California, Santa Barbara’s Dept. of Chemistry and Biochemistry has made a major contribution to this emergent field by developing a light-activated nanocarrier that transports proteins into cells and releases them on command.
Inflammation is a normal and often beneficial response to injury or infection. The swelling, heat and even pain are the body’s attempts to protect its soft tissue, remove offending objects, substances or microbes and initiate healing. However, persistent inflammation is often indicative of more serious conditions and can lead to problems of its own, including impaired healing, loss of function or even tissue death.
A small protein active in the human immune response can disable bacterial toxins by exploiting a property that makes the toxins effective, but also turns out to be a weakness. These toxins, which are released by bacteria, have malleable surfaces that allow them to move through porous areas of host cells to pave the way for bacteria to stay alive. But that same malleability makes the toxins vulnerable to these immune system proteins.
Dissecting neuron function, while crucially important for understanding normal and pathological neurological processes, requires measuring the responses of live cells to external stimuli. Because of the inherent difficulties in performing perturbation analyses inside living organisms, there has been a longstanding drive towards developing methodologies for in vitro analysis of neurons.
Shortly after birth, human brains expand rapidly with the experience of an entirely new world. During this period, neurons in the newborn brain compete with one another to form lasting connections, called synapses. A new study by Duke Univ. researchers provides a close-up of synapse refinement and identifies a protein that is crucial in this process.
Univ. of California, Irvine scientists studying the role of circadian rhythms in skin stem cells found that this clock plays a key role in coordinating daily metabolic cycles and cell division. Their research, which appears in Cell Reports, shows, for the first time, how the body’s intrinsic day-night cycles protect and nurture stem cell differentiation.
Green shoots are a sign of spring, but growing those shoots and roots is a complicated process. Now researchers at the Univ. of California, Davis (UC Davis) and the Univ. of Massachusetts Amherst have, for the first time, described part of the network of genetic controls that allows a plant to grow.
For a skin cell to do its job, it must turn on a completely different set of genes than a liver cell—and keep genes it doesn’t need switched off. One way of turning off large groups of genes at once is to send them to “time-out” at the edge of the nucleus, where they are kept quiet. New research from Johns Hopkins sheds light on how DNA gets sent to the nucleus’ far edge, a process critical to controlling genes and determining cell fate.
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