New research has found that one of the world's most prolific bacteria manages to afflict humans, animals and even plants by way of a mechanism not before seen in any infectious microorganism—a sense of touch. This unique ability helps make the bacteria Pseudomonas aeruginosa ubiquitous, but it also might leave these antibiotic-resistant organisms vulnerable to a new form of treatment.
For such humble creatures, single-celled paramecia have remarkable sensory systems. Give them a sharp jab on the nose, they back up and swim away. Jab them in the behind, they speed up their swimming to escape. But according to new research, when paramecia encounter flat surfaces, they’re at the mercy of the laws of physics.
Massachusetts Institute of Technology (MIT) engineers have transformed the genome of the bacterium E. coli into a long-term storage device for memory. They envision that this stable, erasable and easy-to-retrieve memory will be well suited for applications such as sensors for environmental and medical monitoring.
In the on-going effort to develop advanced biofuels as a clean, green and sustainable source of liquid transportation fuels, researchers at the U.S. Dept. of Energy’s Joint BioEnergy Institute have identified microbial genes that can improve both the tolerance and the production of biogasoline in engineered strains of Escherichia coli.
Researchers report in Nature that they have made a breakthrough in understanding how a powerful antibiotic agent is made in nature. Their discovery solves a decades-old mystery, and opens up new avenues of research into thousands of similar molecules, many of which are likely to be medically useful.
Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.
Microbes populating the human body have good, bad and mostly mysterious implications for our health. But when something goes wrong, we use the brute force of traditional antibiotics, which wipe out everything at once. Researchers at Rockefeller Univ. have developed a more subtle approach that uses the bacterial enzyme known as Cas9 to target a particular sequence of DNA, cutting that up but leaving more innocent microbes alone.
Over the past few years, a class of compounds called ADEPs (cyclic acyldepsipeptides) has emerged as a promising new weapon in the fight against drug-resistant bacteria. The compounds work by attaching themselves to a cellular enzyme called ClpP, which bacterial cells use to rid themselves of harmful proteins. With an ADEP attached, ClpP can’t function properly, and the bacterial cell dies.
Scientists have scoured cow rumens and termite guts for microbes that can efficiently break down plant cell walls for the production of next-generation biofuels, but some of the best microbial candidates actually may reside in the human lower intestine, researchers report. Their studyis the first to use biochemical approaches to confirm the hypothesis that microbes in the human gut can digest fiber.
Each year, new strains of bacteria emerge that resist even the most powerful antibiotics, but scientists have discovered very few new classes of antibiotics in the past decade. Engineers have now turned a powerful new weapon on these superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease.
Shellfish such as mussels and barnacles secrete very sticky proteins that help them cling to rocks or ship hulls, even underwater. Inspired by these natural adhesives, a team of Massachusetts Institute of Technology engineers has designed new materials that could be used to repair ships or help heal wounds and surgical incisions.
No matter how many times it’s demonstrated, it’s still hard to envision bacteria as social, communicating creatures. But by using a signaling system called “quorum sensing,” these single-celled organisms radically alter their behavior to suit their population. In short, some bacteria “know” how many of them are present, and act accordingly.
New research findings point toward future approaches to fighting bacterial biofilms that foul everything from implantable medical devices to industrial pipes and boat propellers. Bacteria secrete a mucus-like “extracellular polymeric substance” that forms biofilms, allowing bacterial colonies to thrive on surfaces.
Bacteria secrete a mucus-like “extracellular polymeric substance” that forms biofilms, allowing bacterial colonies to thrive on surfaces. Costs associated with biofilms affecting medical devices and industrial equipment amount to billions of dollars annually. New research reveals specifics about interactions that induce bacteria to swim close to surfaces and attach to biofilms. This may point to future approaches for fighting biofilms.
The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous intact sequence of DNA, but scientists have now shown that RNA produced within cells of a common budding yeast can serve as a template for repairing the most devastating DNA damage—a break in both strands of a DNA helix.
Sorry, clean freaks. No matter how well you scrub your home, it's covered in bacteria from your own body. And if you pack up and move, new research shows, you'll rapidly transfer your unique microbial fingerprint to the doorknobs, countertops and floors in your new house, too.
The harmful and potentially deadly bacterium Listeria is extremely good at adapting to changes. Research from Denmark uncovers exactly how cunning Listeria is and why it is so hard to fight. The discovery could help develop more efficient ways to combat the bacteria.
The Japanese laboratory that retracted a paper reporting a potentially major breakthrough in stem cell research said Wednesday its researchers have not managed to replicate the results. Scientists at the government-affiliated RIKEN Center for Developmental Biology said they are still trying to match results reported in two papers published by Nature in January and then retracted in July.
For the past 10 years, scientists have been fascinated by a type of “electric bacteria” that shoots out long tendrils like electric wires, using them to power themselves and transfer electricity to a variety of solid surfaces. A team led by scientists has now turned the study of these bacterial nanowires on its head, discovering that the key features in question are not pili as previously believed.
Rice Univ. scientists have won a race to find the crystal structure of the first virus known to infect the most abundant animal on Earth. The Rice laboratories of structural biologist Yizhi Jane Tao and geneticist Weiwei Zhong, with help from researchers at Baylor College of Medicine and Washington Univ., analyzed the Orsay virus that naturally infects a certain type of nematode, the worms that make up 80% of the living animal population.
Imitation, they say, is the sincerest form of flattery, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Now, as published in Science, Weizmann Institute scientists have created an artificial, network-like cell system that is capable of reproducing the dynamic behavior of protein synthesis.
Recent research has made a significant contribution to the understanding of a new field of DNA research that is based on a repetitive piece of DNA in the bacterial genome called a CRISPR. The study provides the first detailed blueprint for this multi-subunit “molecular machinery” that bacteria use to detect and destroy invading viruses.
A fundamental chemical pathway that all plants use to create an essential amino acid needed by all animals to make proteins has now been traced to two groups of ancient bacteria. The pathway is also known for making hundreds of chemicals, including a compound that makes wood strong and the pigments that make red wine red.
According to recent research that marks the first time investigators have taken a microbial census of a sake brewery, the microbial populations found on surfaces in the facility resemble those found in the product, creating the final flavor. This means a sake brewery has its own microbial terroir.
The drought that has the entire country in its grip is affecting more than the color of people’s lawns. It may also be responsible for the proliferation of a heat-loving amoeba commonly found in warm freshwater bodies, such as lakes, rivers and hot springs, which the drought has made warmer than usual this year.