A Univ. of Otago scientist is a member of an international research team that has made an important discovery about the workings of a bacterial immune system. The finding could lead to the development of tailor-made RNA-editing tools. RNA is the molecule that translates DNA's genetic instructions into the production of the proteins that are the building blocks of cells.
Scientists focused on producing biofuels more efficiently have a new powerful data set to help...
With rising populations and changing climate conditions, the need for resilient and reliable...
Univ. of Notre Dame applied mathematician Mark Alber and environmental biotechnologist Robert...
An experimental drug that attacks brain tumor tissue by crippling the cells' energy source called the mitochondria has passed early tests in animal models and human tissue cultures, say Houston Methodist scientists.
Chemical reactions involving reduction and oxidation, or redox, play a key role in regulating photosynthesis in plants and metabolism in animals and humans, keeping things running on an even keel. Now, in a recently published study, a team of scientists shed light on the role redox plays in cyanobacteria, tiny organisms with the potential to produce a lot of energy.
Rice Univ. bioengineers are teaming with colleagues from Baylor College of Medicine and MD Anderson Cancer Center to apply the latest techniques in tissue engineering toward the study of one of the most common and deadly human illnesses: the stomach flu. The bacteria and viruses that cause acute gastroenteritis often come from contaminated food or water and result in cramps, nausea, diarrhea and vomiting.
As the Arctic warms, tons of carbon locked away in Arctic tundra will be transformed into the powerful greenhouse gases carbon dioxide and methane, but scientists know little about how that transition takes place. Now, scientists looking at microbes in different types of Arctic soil have a new picture of life in permafrost that reveals entirely new species and hints that subzero microbes might be active.
Scientific debate has been hot lately about whether microbial nanowires, the specialized electrical pili of the mud-dwelling anaerobic bacterium Geobacter sulfurreducens, truly possess metallic-like conductivity as its discoverers claim. But now a Univ. of Massachusetts Amherst team says they settled the dispute between theoretical and experimental scientists by devising a combination of new experiments and better theoretical modeling.
A powerful genome editing tool may soon become even more powerful. Researchers with the Lawrence Berkeley National Laboratory have unlocked the key to how bacteria are able to “steal” genetic information from viruses and other foreign invaders for use in their own immunological memory system.
Scientists have captured the first detailed microscopy images of ultra-small bacteria that are believed to be about as small as life can get. The existence of ultra-small bacteria has been debated for two decades, but there hasn’t been a comprehensive electron microscopy and DNA-based description of the microbes until now.
When exposed to nitrogen fertilizer over a period of years, nitrogen-fixing bacteria called rhizobia evolve to become less beneficial to legumes, researchers report in a new study. These findings, reported in Evolution, may be of little interest to farmers, who generally grow only one type of plant and can always add more fertilizer to boost plant growth.
Bacteria may not have brains, but they do have memories, at least when it comes to viruses that attack them. Many bacteria have a molecular immune system which allows these microbes to capture and retain pieces of viral DNA that they have encountered in the past, in order to recognize and destroy it when it shows up again.
Rivers and streams could be a major source of antibiotic resistance in the environment. The discovery comes following a study on the Thames river by scientists at the Univ. of Warwick and the Univ. of Exeter. The study found that greater numbers of resistant bacteria exist close to some waste water treatment works, and that these plants are likely to be responsible for at least half of the increase observed.
Imagine thousands of copies of a single protein organizing into a coat of chainmail armor that protects the wearer from harsh and ever-changing environmental conditions. That is the case for many microorganisms. In a new study, researchers with Lawrence Berkeley National Laboratory have uncovered key details in this natural process that can be used for the self-assembly of nanomaterials into complex 2- and 3-D structures.
In shallow waters around the world, where nutrient pollution runs high, oxygen levels can plummet to nearly zero at night. Oysters living in these zones are far more likely to pick up the lethal Dermo disease.
More than 80% of microbial infections in the human body are caused by a build–up of bacteria, according to the National Institutes of Health. Bacteria cells gain a foothold in the body by accumulating and forming into adhesive colonies called biofilms, which help them to thrive and survive but cause infections and associated life–threatening risks to their human hosts.
From manufacturing life-saving biopharmaceuticals to producing energy-efficient biofuels, the cost-effective production of proteins will be essential to revolutionizing the future of health care and energy. For years, scientists have turned to yeast as a quick and inexpensive way to mass-produce proteins for a variety of useful products. Now Northwestern Univ. has found a way to gather more protein without making the yeast produce more.
Indiana Univ. biologists believe they have found a faster, cheaper and cleaner way to increase bioethanol production by using nitrogen gas, the most abundant gas in Earth’s atmosphere, in place of more costly industrial fertilizers. The discovery could save the industry millions of dollars and make cellulosic ethanol more competitive with corn ethanol and gasoline.
Cyanobacteria, bacteria that obtain their energy through photosynthesis, are of considerable interest as bio-factories, organisms that could be harnessed to generate a range of industrially useful products. Part of their appeal is that they can grow on sunlight and carbon dioxide alone and thus could contribute to lowering greenhouse gas emissions and moving away from a petrochemical-based economy.
E. coli usually brings to mind food poisoning and beach closures, but researchers recently discovered a protein in E. coli that inhibits the accumulation of potentially toxic amyloids, a hallmark of diseases such as Parkinson's. Amyloids are formed by proteins that misfold and group together, and when amyloids assemble at the wrong place or time, they can damage brain tissue and cause cell death.
The creation of genetically modified and entirely synthetic organisms continues to generate excitement as well as worry. Such organisms are already churning out insulin and other drug ingredients, helping produce biofuels and teaching scientists about human disease. While the risks can be exaggerated to frightening effect, modified organisms do have the potential to upset natural ecosystems if they were to escape.
Bacteria have been modified so that they die if they get out of human control, a potential step toward better management of genetically engineered organisms—perhaps including crops, researchers say. Genetically altered microbes are used now in industry to produce fuels, medicines and other chemicals. The new technique might also reduce the risk of using them outdoors, such as for cleaning up toxic spills.
Just as the invention of non-stick pans was a boon for chefs, a new type of nanoscale surface that bacteria can’t stick to holds promise for applications in the food processing, medical and even shipping industries. The technology uses an electrochemical process called anodization to create nanoscale pores that change the electrical charge and surface energy of a metal surface.
For years, pathogens’ resistance to antibiotics has put them one step ahead of researchers, which is causing a public health crisis, according to Northeastern Univ. Distinguished Prof. Kim Lewis. But in new research, Lewis and his colleagues present a newly discovered antibiotic that eliminates pathogens without encountering any detectable resistance.
A small protein active in the human immune response can disable bacterial toxins by exploiting a property that makes the toxins effective, but also turns out to be a weakness. These toxins, which are released by bacteria, have malleable surfaces that allow them to move through porous areas of host cells to pave the way for bacteria to stay alive. But that same malleability makes the toxins vulnerable to these immune system proteins.
With drug-resistant bacteria on the rise, even common infections that were easily controlled for decades are proving trickier to treat with standard antibiotics. New drugs are desperately needed, but so are ways to maximize the effective lifespan of these drugs. To accomplish that, Duke Univ. researchers used software they developed to predict a constantly evolving infectious bacterium's countermoves to one of these new drugs ahead of time.
Rapidly growing bacteria that live in the ocean and can manufacture their own food hold promise as host organisms for producing chemicals, biofuels and medicine. Researchers are closely studying one of these photosynthetic species of fast-growing cyanobacteria using advanced tools developed at Pacific Northwest National Laboratory to determine the optimum environment that contributes to record growth and productivity.
Two years ago, researchers at the Joint BioEnergy Institute engineered E. coli bacteria to convert glucose into significant quantities of methyl ketones, a class of chemical compounds primarily used for fragrances and flavors, but highly promising as clean, green and renewable blending agents for diesel fuel. Now, after further genetic modifications, they have managed to dramatically boost the E.coli’s methyl ketone production 160-fold.
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