Tuberculosis is caused by a bacterium that infects the lungs of an estimated 8.6 million people worldwide. The fight against the disease is hampered by the fact that treatment requires a long time and that the bacterium often develops multi-drug resistance. Scientists have used a sensitive screening assay to test new compounds that can be used against the bacterium, and have discovered two small molecules that show remarkable promise.
Over the past few years, a class of compounds called ADEPs (cyclic acyldepsipeptides) has...
Scientists have scoured cow rumens and termite guts for microbes that can efficiently break down...
Each year, new strains of bacteria emerge that resist even the most powerful antibiotics, but scientists have discovered very few new classes of antibiotics in the past decade. Engineers have now turned a powerful new weapon on these superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease.
Shellfish such as mussels and barnacles secrete very sticky proteins that help them cling to rocks or ship hulls, even underwater. Inspired by these natural adhesives, a team of Massachusetts Institute of Technology engineers has designed new materials that could be used to repair ships or help heal wounds and surgical incisions.
No matter how many times it’s demonstrated, it’s still hard to envision bacteria as social, communicating creatures. But by using a signaling system called “quorum sensing,” these single-celled organisms radically alter their behavior to suit their population. In short, some bacteria “know” how many of them are present, and act accordingly.
New research findings point toward future approaches to fighting bacterial biofilms that foul everything from implantable medical devices to industrial pipes and boat propellers. Bacteria secrete a mucus-like “extracellular polymeric substance” that forms biofilms, allowing bacterial colonies to thrive on surfaces.
Bacteria secrete a mucus-like “extracellular polymeric substance” that forms biofilms, allowing bacterial colonies to thrive on surfaces. Costs associated with biofilms affecting medical devices and industrial equipment amount to billions of dollars annually. New research reveals specifics about interactions that induce bacteria to swim close to surfaces and attach to biofilms. This may point to future approaches for fighting biofilms.
The ability to accurately repair DNA damaged by spontaneous errors, oxidation or mutagens is crucial to the survival of cells. This repair is normally accomplished by using an identical or homologous intact sequence of DNA, but scientists have now shown that RNA produced within cells of a common budding yeast can serve as a template for repairing the most devastating DNA damage—a break in both strands of a DNA helix.
Sorry, clean freaks. No matter how well you scrub your home, it's covered in bacteria from your own body. And if you pack up and move, new research shows, you'll rapidly transfer your unique microbial fingerprint to the doorknobs, countertops and floors in your new house, too.
The harmful and potentially deadly bacterium Listeria is extremely good at adapting to changes. Research from Denmark uncovers exactly how cunning Listeria is and why it is so hard to fight. The discovery could help develop more efficient ways to combat the bacteria.
The Japanese laboratory that retracted a paper reporting a potentially major breakthrough in stem cell research said Wednesday its researchers have not managed to replicate the results. Scientists at the government-affiliated RIKEN Center for Developmental Biology said they are still trying to match results reported in two papers published by Nature in January and then retracted in July.
For the past 10 years, scientists have been fascinated by a type of “electric bacteria” that shoots out long tendrils like electric wires, using them to power themselves and transfer electricity to a variety of solid surfaces. A team led by scientists has now turned the study of these bacterial nanowires on its head, discovering that the key features in question are not pili as previously believed.
Rice Univ. scientists have won a race to find the crystal structure of the first virus known to infect the most abundant animal on Earth. The Rice laboratories of structural biologist Yizhi Jane Tao and geneticist Weiwei Zhong, with help from researchers at Baylor College of Medicine and Washington Univ., analyzed the Orsay virus that naturally infects a certain type of nematode, the worms that make up 80% of the living animal population.
Imitation, they say, is the sincerest form of flattery, but mimicking the intricate networks and dynamic interactions that are inherent to living cells is difficult to achieve outside the cell. Now, as published in Science, Weizmann Institute scientists have created an artificial, network-like cell system that is capable of reproducing the dynamic behavior of protein synthesis.
Recent research has made a significant contribution to the understanding of a new field of DNA research that is based on a repetitive piece of DNA in the bacterial genome called a CRISPR. The study provides the first detailed blueprint for this multi-subunit “molecular machinery” that bacteria use to detect and destroy invading viruses.
A fundamental chemical pathway that all plants use to create an essential amino acid needed by all animals to make proteins has now been traced to two groups of ancient bacteria. The pathway is also known for making hundreds of chemicals, including a compound that makes wood strong and the pigments that make red wine red.
According to recent research that marks the first time investigators have taken a microbial census of a sake brewery, the microbial populations found on surfaces in the facility resemble those found in the product, creating the final flavor. This means a sake brewery has its own microbial terroir.
The drought that has the entire country in its grip is affecting more than the color of people’s lawns. It may also be responsible for the proliferation of a heat-loving amoeba commonly found in warm freshwater bodies, such as lakes, rivers and hot springs, which the drought has made warmer than usual this year.
When it comes to swimming, the bodies of some bacteria are more than just dead weight, according to new research from Brown Univ. Many bacteria swim using flagella, corkscrew-like appendages that push or pull bacterial cells like tiny propellers. It's long been assumed that the flagella do all the work during swimming, while the rest of the cell body is just along for the ride.
Researchers in Kentucky have developed a technology that uses male mosquitoes to effectively sterilize females through a naturally occurring bacterium. Called MosquitoMate, the new technology has been issued an experimental use permit for open field releases targeting the invasive Asian tiger mosquito, which is a vector for newly introduced pathogens like the Chikungunya virus.
We are all creatures of habit, and a new study finds ocean bacteria are no exception. In a paper published in Science, researchers report that microbes in the open ocean follow predictable patterns of biological activity, such as eating, breathing and growing. Certain species are early risers, exhibiting genetic signs of respiration, metabolism and protein synthesis in the morning hours, while others rouse to action later in the day.
Researchers from North Carolina State Univ. and the Univ. of Minnesota have found, for the first time, that genetically identical strains of bacteria can respond very differently to the presence of sugars and other organic molecules in the environment, with some individual bacteria devouring the sugars and others ignoring it.
Using the quantitative approach of physicists, biologists in Israel have developed experimental tools to measure precisely the bacterial response to antibiotics. Their mathematical model of the process has led them to hypothesize that a daily three-hour dose would enable the bacteria to predict delivery of the drug, and go dormant for that period in order to survive.
Genomic sequencing is supposed to reveal the entire genetic makeup of an organism. The technology can be used to analyze a disease-causing bacterium to determine how much harm it is capable of causing. But new research at Rockefeller Univ. suggests that current sequencing protocols overlook crucial bits of information: isolated pieces of DNA floating outside the bacterial chromosome, the core of a cell’s genetic material.
Trillions of bacteria live in and on the human body; a few species can make us sick, but many others keep us healthy by boosting digestion and preventing inflammation. Although there's plenty of evidence that these microbes play a collective role in human health, we still know very little about most of the individual bacterial species that make up these communities.
Researchers at The Johns Hopkins Univ. report they have deciphered the inner workings of a protein called YiiP that prevents the lethal buildup of zinc inside bacteria. They say understanding YiiP's movements will help in the design of drugs aimed at modifying the behavior of ZnT proteins, eight human proteins that are similar to YiiP, which play important roles in hormone secretion and in signaling between neurons.
Researchers at the Univ. of Michigan have obtained the first 3-D snapshots of the "assembly line" within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.
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