Zinc deficiency, long associated with numerous diseases like certain cancers, can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute.
Gel permeation/size exclusion chromatography (GPC/SEC) is a vital analytical technique used to...
At the 66th annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (...
A newly developed spectroscopy method is helping to clarify the poorly understood molecular...
NIST researchers have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies, an important factor in determining the safety and efficacy of these biomolecules as medicines. Monoclonal antibodies are proteins manufactured in the laboratory that can target specific disease cells or antigens (proteins that trigger an immune reaction) for removal from the body.
A vibrational spectroscopic imaging technology that can take images of living cells could represent an advanced medical diagnostic tool for the early detection of cancer and other diseases. High-speed spectroscopic imaging makes it possible to observe the quickly changing metabolic processes inside living cells and to image large areas of tissue, making it possible to scan an entire organ.
Liquid chromatography-mass spectrometry (LC-MS) is taking over as an analytical technique of choice in diverse fields. While a LC-MS analyst may be tempted to rely on the most commonly used sample prep techniques, columns and mobile phases in his/her field, we show successful LC-MS demands these workflow elements be chosen with the physico-chemical properties of the analyte in mind.
A new twist on an old tool lets scientists use light to study and control matter with 1,000 times better resolution and precision than previously possible. Physicists at the Univ. of Michigan have demonstrated "ponderomotive spectroscopy," an advanced form of a technique that was born in the 17th century when Isaac Newton first showed that white light sent through a prism breaks into a rainbow.
Lab automation systems are used in R&D laboratories for a wide range of operational applications and purposes. According to a recent reader survey performed by the editors of R&D Magazine in late-2014, the top three applications include to improve the accuracy of lab operations (selected by 61% of the readers), to improve lab productivity (58%) and to ensure the reliability of the lab operations (48%).
Reliable pH measurements are essential to a variety of processes and industries. From agriculture, to wastewater and plating, to food processing, measuring pH is a crucial step in determining the efficiency of a process or quality of a product. Vital steps in achieving accurate pH results include calibrating a pH meter and ensuring the electrode is working properly.
Developing renewable fuel from wet algae and enabling analysis of complex liquids are two of the latest innovations Pacific Northwest National Laboratory (PNNL) has successfully driven to the market with the help of commercial partners.
Training of first responders on the hazards of actual radiological and nuclear threats has been challenged by the difficulties of adequately representing those threats. Training against such threats would involve using hazardous, highly radioactive materials, experiencing actual radiation doses in training, or require the distribution of radioactive material over a large geographical area.
It has been taken for granted for over 50 years that the type of spectroscopy widely used to study hydrogen inside materials is not subject to any selection rules. In the joint theoretical and experimental study that appeared recently in Physical Review Letters, an international team of researchers showed that this near universally held view is incorrect for at least one important class of hydrogen-entrapping compounds.
Foodborne illnesses kill roughly 3,000 Americans each year and about one in six are sickened, according to the Centers for Disease Control and Prevention. Yet most contaminated foods are never traced back to their source. That’s because existing methods to track tainted food following its supply chain from table to farm are highly inefficient, jeopardizing the health of millions and costing the food industry billions.
Dissecting neuron function, while crucially important for understanding normal and pathological neurological processes, requires measuring the responses of live cells to external stimuli. Because of the inherent difficulties in performing perturbation analyses inside living organisms, there has been a longstanding drive towards developing methodologies for in vitro analysis of neurons.
Lawrence Livermore National Laboratory researchers in conjunction with collaborators at Univ. of California, Los Angeles have found that some cells build intracellular compartments that allow the cell to store metals and maintain equilibrium. Nearly 40% of all proteins require metal ions such as zinc, copper, manganese or iron for activity.
One major challenge currently facing the graphene industry is difficulty in controlling the quality of graphene sheets when produced over large areas using industrial scale techniques. The key to solving this challenge lies in gaining a thorough understanding of the synthetic methods used to fabricate macro-sized single-layer graphene films.
Nearly half of all U.S. adults, nearly 117 million individuals, are living with one or more chronic health conditions. This has become the age of chronic disease, and achieving better outcomes depends on developing tools for research and clinical care that efficiently and accurately address the complex diseases we face today.
During the 2014 R&D 100 Awards event, R&D Magazine expanded the banquet to hold four technology panels during the day. The first panel focused on analytical instrumentation and the innovation behind four R&D 100-winning technologies and the complexity of bringing such instrumentation to the market.
Hydrocarbon exploration by definition is the search by geologists or geophysicists for hydrocarbon deposits beneath the Earth’s surface, such as oil (petroleum) and natural gas. In such exploration, the oil and gas industry drills holes into the Earth’s surface to extract the petroleum or natural gas. However, such exploration is expensive, not to mention a high-risk operation.
Researchers have combined key features of two highly acclaimed x-ray spectroscopy techniques into a new technique that offers sub-nanometer resolution of every chemical element to be found at heterogeneous interfaces, such as those in batteries and fuel cells. This new technique is called SWAPPS for Standing Wave Ambient Pressure Photoelectron Spectroscopy.
Fluorocarbon, a generic term for organic compounds with carbon-fluorine (C-F) bonding, is a chemical material used as a refrigerant in refrigerators and freezers and air conditioners in cars, buses, other vehicles and buildings. It’s also used as a cleaning agent for electronic components and precision parts.
Near-infrared (NIR) spectrometers have been around for over 60 years, yet only a small fraction of the population is familiar with these dependable tools. It’s astounding that NIR spectroscopy does so much for so many people who have never heard the word “spectrometer.” NIR spectrometers help a diverse set of users make decisions in their daily jobs.
The “surfactant” chemicals found in samples of fracking fluid collected in five states were no more toxic than substances commonly found in homes, according to a first-of-its-kind analysis by researchers at the Univ. of Colorado Boulder. Fracking fluid is largely comprised of water and sand, but oil and gas companies also add a variety of other chemicals, including surfactants.
Demand for mass spectrometry continues to rise. According to a recent Marketsandmarkets report, the global mass spectrometry market is expected to reach $5.9 billion by 2018. That’s a healthy compounded annual growth rate of 8.7%. Since its earliest demonstration more than 100 years ago, this analytical technique has become known as the “gold standard” of chemical analysis.
A diet rich in fruit and vegetables is linked to a variety of improved health outcomes, but accurately measuring consumption by self-report, especially with children, is challenging and can be of questionable validity. But a device being developed in a collaboration that involves researchers from the Yale School of Public Health has the potential to change that.
Given today’s widespread use of Raman spectroscopy, it can be hard to believe Raman was a highly specialized analytical technique for most of its history. The technique’s potential was recognized from the beginning: When Raman scattering was first observed in 1928, it was widely believed to be one of the most important scientific discoveries of the 20th century to date.
Rice Univ. researchers have delivered a scientific one-two punch with a pair of papers that detail how synthetic collagen fibers self-assemble via their sticky ends. Collagen is the most common protein in mammals, a major component of bone and the fibrous tissues that support cells and hold organs together. Discovering its secrets may lead to better synthetic collagen for tissue engineering and cosmetic and reconstructive medicine.
As a laboratory technician or director, knowing the current status of your instrument or sample runs is critical for your laboratory’s operations and productivity. Through the rapid increase in machine-to-machine connectivity, real-time instrument monitoring services designed to offer visibility and remote control of these instruments has become an enabler in cost savings, efficiency gains, revenue opportunities and competitive advantage.
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