Researchers at the University of Wisconsin-Madison have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.
A quick, accurate, and highly sensitive process to reliably detect minute traces of explosives on luggage, cargo, or traveling passengers has been demonstrated by scientists at Pacific Northwest National Laboratory. The vapor detection technology accurately detects and identifies the vapors of even very low-volatility explosives in real time at ambient temperature and without sample pre-concentration.
The Lycurgus cup was created by the Romans in 400 A.D. Made of a dichroic glass, the famous cup exhibits different colors depending on whether or not light is passing through it; red when lit from behind and green when lit from in front. It is also the origin of inspiration for all contemporary nanoplasmonics research—the study of optical phenomena in the nanoscale vicinity of metal surfaces. Scientists have recently used these optical characteristics to create a novel, ultra-sensitive tool for chemical, DNA, and protein analysis.
Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function in the formation of tissue structures and organs. It's thought that abnormalities in their ability to do so play an important role in a broad range of disorders, including cardiovascular disease and cancer.
Magnetic resonance imaging (MRI) reveals details of living tissues, diseased organs and tumors inside the body without x-rays or surgery. What if the same technology could peer down to the level of atoms? Physicists in New York and Germany have worked together to make this type of nanoscale MRI possible. To do this, researchers used the tiny imperfections in diamond crystals known as nitrogen-vacancy centers.
Miniaturized laboratory-on-chip systems promise rapid, sensitive, and multiplexed detection of biological samples for medical diagnostics, drug discovery, and high-throughput screening. Using microfabrication techniques and incorporating a unique design of transistor-based heating, researchers at the University of Illinois at Urbana-Champaign are further advancing the use of silicon transistor and electronics into chemistry and biology for point-of-care diagnostics.
In a study designed to find out how smell is written into a molecule’s structure, scientists in England tested whether changing how a molecule vibrates on a nanoscale changes its smell. They found that molecular vibrations, rather than molecular shape, give substances their distinct smell.
In a study published in Nano Letters, Lawrence Livermore National Laboratory (LLNL)'s Mike Malfatti, Heather Palko, Ed Kuhn, and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long-term biodistribution of carbon 14-labeled silica nanopartocles in vivo.
Tiny calcium deposits can be a telltale sign of breast cancer. However, in the majority of cases these microcalcifications signal a benign condition. A new diagnostic procedure developed at Massachusetts Institute of Technology and Case Western Reserve University could help doctors more accurately distinguish between cancerous and noncancerous cases.
Agilent Technologies, Inc.and Spain’s Centre for Omic Sciences this week announced that they will collaborate on mass spectrometry and nuclear magnetic resonance-based metabolomics, and automation applied to research in integrated systems biology.
When someone develops liver cancer, the disease introduces a very subtle difference to their bloodstream, increasing the concentration of a particular molecule by just 10 parts per billion. That small shift is normally difficult to detect without sophisticated equipment, but new lab-on-a-chip technology designed at Brigham Young University can reveal the presence of ultra-low concentrations of a target molecule.
Drugs that target cell function must pass through a tough gauntlet of membrane defenses. Working from the knowledge that thin water layers at the membrane surfaces play a big part in ion and small molecule transport, scientists using rapid-fire lasers in Japan have revealed that water molecules adopt three distinct local structures around model lipid monolayers. The finding could help drive drug development.
The winners of the 2012 Chemistry Nobel Prize won for their work in revealing the structure and functioning of a key protein complex on the surface of human cells that has been a target for drug development. Their main tool for this research was X-ray crystallography, which is performed with X-ray synchrotrons. But as the researchers would discover, not all synchrotrons are created equal.
Using in silico computational tools to complement the results of in vivo and in vitro experiments, researchers at Pacific Northwest National Laboratory have revealed an atomic-level understanding of the mechanism by which nanoparticles inhibit the growth and metastasis of pancreatic tumors. The findings are promising for the development of particle-based therapies.
After leading mass spectrometer manufacturers agreed to license technology that has enabled researchers to develop software allows scientists to easily use and share research data collected across proprietary instrument platforms. Called the ProteoWizard Toolkit, this cross-platform set of libraries and applications is expected to bolster large-scale biological research and help improve the understanding of complex diseases like cancer.
Following the completion of a highly successful early access program, Malvern Instruments has now launched the Morphologi G3-ID particle characterization system. This fully automated system measures particle size, shape and chemical identity in a single platform.
The ability to determine the composition and physics of nanoscale materials and devices at NIST is about to improve dramatically with the arrival of a new near-field scanning microwave microscope (NSMM) design. Researchers there, using existing commercial and homemade NSMMs, have pioneered many applications, notably including determination of semiconductor dopant distribution in 2D and 3D. Now they hope to look at mechanical and magnetic resonance on the nanoscale.
The system currently being used to test for mercury and its very toxic derivative, methyl mercury, is time-intensive, costly, and can only detect quantities at already toxic levels. Researchers at Northwestern University and in Switzerland have invented a device consisting of a strip of glass with a nanoparticle film attached that can detect heavy metals in quantities more than a million times smaller than is currently possible.
Researchers from Pacific Northwest National Laboratory have reported this week that combining two well-established analytic techniques?and adding a twist?identifies proteins from blood with as much accuracy and sensitivity as the antibody-based tests used clinically. The new mass spectrometry technique, called PRISM, should be able to speed up development of diagnostic tests and treatments based on proteins specific to certain diseases.
In addition to releasing spectacular new telephoto images of the Martian surface, NASA also used the rover to relay a voice message from NASA’s administrator, Charles Bolden, from Earth to Mars and back. The new images were taken by the 100-mm telephoto lens and the 34-mm wide angle lens of the Mast Camera instrument, which photographed the lower slopes of Mount Sharp.
Highly sensitive and highly selective tests for early disease detection, environmental toxin detection, orthe detection of explosives at airports helps avoid false-positive results. Indian scientists have recently introduced a specific detection method for the explosive TNT that is selective for analytes it can be used to detect even a single molecule.
University of Miami scientists have developed a way to switch fluorescent molecules on and off within aqueous environments by strategically trapping the molecules inside water-soluble particles and controlling them with ultraviolet light. The new system can be used to develop better fluorescent probes for biomedical research.
Researchers the University of Texas, Dallas have found a way to monitor DNA looping, a natural biological mechanism involved in rearranging genetic material in some types of cells. Until now, scientists primarily had “snapshots” of the initial and final stages of DNA loop formation, but the new “tag and track” method uses fluorescence to watch the process step by step.
Thermo Fisher Scientific Inc. has entered into a technology alliance partnership agreement with scientists at Princeton University, establishing a formal collaboration to accelerate research in triple quadrupole and high-resolution accurate mass liquid chromatography-mass spectrometry for life science applications.
The question of just how a cell membrane—which is otherwise an impermeable barrier—allows certain proteins to penetrate it remains largely a mystery. But an answer may be closer after measurements taken at the NIST and France's Institut Laue-Langevin, where scientists have observed changes in the thickness of a model cell membrane for the first time.