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Robotic instruments provide real-time data on Maine red tide

May 8, 2013 12:36 pm | News | Comments

A robotic sensor that won an R&D 100 Award in 2009 has been put to use by Woods Hole Oceanographic Institution (WHOI) in Gulf of Maine coastal waters to monitor the way red tides behave. These harmful algal blooms, which generate a potentially fatal toxin, can be a challenge to track or predict. The Environmental Sample Processors have been remotely deployed and should simplify and enhance this effort.

An electronic nose can tell pears and apples apart

May 8, 2013 12:13 pm | News | Comments

Swedish and Spanish engineers have created a system of sensors that detects fruit odors more effectively than the human sense of smell. For now, the device, which has 32 sensors and can process scent data in real time, can distinguish between the odorous compounds emitted by pears and apples, but the system can be tailored to other applications.

New imaging technique visualizes bio-metals and molecules simultaneously

May 2, 2013 2:25 pm | by Juliette Savin, RIKEN | News | Comments

Metal elements and molecules interact in the body, but visualizing them together has always been a challenge. Researchers at RIKEN in Japan have developed a new molecular imaging technology that enables them to image bio-metals and bio-molecules at the same time in a live mouse. This new technology will enable researchers to study the complex interactions between metal elements and molecules in living organisms.

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Tests on cancer cells shows them as “squishy”, yet tactically strong

April 29, 2013 8:06 am | News | Comments

To get a better understanding of metastasis, more than 95 graduate students, post docs and professors in a variety of laboratories across the U.S. subjected two cell lines to a battery of tests and measurements using more than 20 different techniques. The work has enabled a comprehensive cataloging and comparison of the physical characteristics of non-malignant and metastatic cells.

Thermo to acquire Life Technologies

April 16, 2013 7:30 am | News | Comments

Thermo Fisher Scientific Inc. and Life Technologies Corporation have signed a definitive agreement under which Thermo Fisher will acquire Life Technologies for $76.00 in cash per fully diluted common share, or approximately $13.6 billion, plus the assumption of net debt at close ($2.2 billion as of year end 2012).

AB SCIEX enhances software to drive micro LC

March 20, 2013 10:10 am | News | Comments

New software and service offerings to simplify and accelerate the integration of micro liquid chromatography (LC) technology into regulated bioanalytical laboratories was introduced this week by AB SCIEX. The new software module supports 21CFR Part 11 and the new IQ/OQ/PQ service to the Eksigent line of LC solutions gives research organizations a new validated approach to micro LC

Team achieves tenfold boost in ability to find proteins in cancer cells

March 19, 2013 3:59 pm | by Michelle Ma, University of Washington | News | Comments

New research offers a more comprehensive way of analyzing one cell’s unique behavior, using an array of colors to show patterns that could indicate why a cell will or won’t become cancerous. A University of Washington team has developed a new method for color-coding cells that allows them to illuminate 100 biomarkers, a ten-time increase from the current research standard

Wyss Institute, Sony DADC collaborate on Organs-on-Chips

March 19, 2013 8:01 am | News | Comments

This week, the Wyss Institute for Biologically Inspired Engineering at Harvard University and Sony DADC announced a collaboration that will harness Sony DADC's global manufacturing expertise to further advance the Institute's Organs-on-Chips technologies. Human Organs-on-Chips are research tools composed of a clear, flexible polymer about the size of a computer memory stick, and contain hollow microfluidic channels lined by living human cells

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High-resolution endoscope is as thin as a human hair

March 13, 2013 10:09 am | by Andrew Myers, Stanford University | News | Comments

Engineers at Stanford have developed a prototype single-fiber endoscope that improves the resolution of these much-sought-after instruments fourfold over existing designs. This so-called micro-endoscope can resolve objects just 2.5 micrometers in size and could lead to an era of needle-thin, minimally invasive endoscopes able to view features out of reach of today’s instruments.

Rapid cancer detection built on a chip

March 8, 2013 3:39 pm | News | Comments

Early detection is vital for the effective treatment of cancer. In many cases, tell-tale biomarkers are present in the bloodstream long before outward symptoms become apparent. The development of an inexpensive and rapid point-of-care diagnostic test capable of spotting such early biomarkers of disease could save many lives. A research team in Japan working on developing such a test has now produced their most sensitive microRNA detector yet.

Thermally controlled nanopores may allow detailed blood analysis

March 7, 2013 10:02 am | News | Comments

Tiny biomolecular chambers called nanopores that can be selectively heated may help doctors diagnose disease more effectively if recent research by a team at NIST proves effective. The team has pioneered work on the use of nanopores for the detection and identification of a wide range of molecules, including DNA. These nanopores mimic ion channels, the gateways by which a cell admits and expels materials.

Polymer scientists develop double switchable membrane

February 27, 2013 10:46 pm | News | Comments

Pharmaceutical residues in water can pose a danger to humans. Filtration is often very difficult as these trace substances, which are soluble in water, are so minute. Newly-developed double switchable membranes could make it possible to filter these molecules, as well as other  biomolecules such as proteins and nucleic acids. The new membranes can reduce or enlarge pore size through changes in temperature and pH value.

Automating Challenges Associated with Proteomics Workflows

February 26, 2013 4:16 pm | by Brian Field, Life Science Product Manager, Shimadzu Scientific Instruments, Columbia, Md. | Articles | Comments

Sample preparation workflows for mass spectrometric analysis that involve proteolysis are often labor intensive, time consuming, and user dependent. Typical proteomic workflows require enzymatic digestion, solid phase extraction, drying, and resuspension before the reversed phase liquid chromatography-mass spectrometry (LC-MS) analysis.

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Rethinking Automation

February 26, 2013 4:11 pm | by Matt Kirtley, Product Manager, Agilent Technologies Inc., Santa Clara, Calif. | Articles | Comments

Until now, life science researchers had a narrow set of expectations for automation systems. The main focus of laboratory automation providers has been to develop liquid handling systems for high-throughput workflows processing very large samples numbers, primarily in screening laboratories.

Analytical trick may accelerate cancer diagnosis

February 25, 2013 7:59 am | News | Comments

Researchers at the University of Wisconsin-Madison have found a new way to accelerate a workhorse instrument that identifies proteins. The high-speed technique could help diagnose cancer sooner and point to new drugs for treating a wide range of conditions.

Explosives vapor detection technology: The new "sniff test"

February 21, 2013 8:35 am | News | Comments

A quick, accurate, and highly sensitive process to reliably detect minute traces of explosives on luggage, cargo, or traveling passengers has been demonstrated by scientists at Pacific Northwest National Laboratory. The vapor detection technology accurately detects and identifies the vapors of even very low-volatility explosives in real time at ambient temperature and without sample pre-concentration.

World's most sensitive plasmon resonance sensor inspired by ancient Roman cup

February 15, 2013 10:07 am | News | Comments

The Lycurgus cup was created by the Romans in 400 A.D. Made of a dichroic glass, the famous cup exhibits different colors depending on whether or not light is passing through it; red when lit from behind and green when lit from in front. It is also the origin of inspiration for all contemporary nanoplasmonics research—the study of optical phenomena in the nanoscale vicinity of metal surfaces. Scientists have recently used these optical characteristics to create a novel, ultra-sensitive tool for chemical, DNA, and protein analysis.

Why cells stick: Phenomenon extends longevity of bonds between cells

February 15, 2013 8:50 am | News | Comments

Research carried out by scientists at the Georgia Institute of Technology and The University of Manchester has revealed new insights into how cells stick to each other and to other bodily structures, an essential function in the formation of tissue structures and organs. It's thought that abnormalities in their ability to do so play an important role in a broad range of disorders, including cardiovascular disease and cancer.

Team creates MRI for the nanoscale

February 14, 2013 11:59 am | News | Comments

Magnetic resonance imaging (MRI) reveals details of living tissues, diseased organs and tumors inside the body without x-rays or surgery. What if the same technology could peer down to the level of atoms? Physicists in New York and Germany have worked together to make this type of nanoscale MRI possible. To do this, researchers used the tiny imperfections in diamond crystals known as nitrogen-vacancy centers.

Building a biochemistry lab-on-a-chip

February 13, 2013 8:04 am | News | Comments

Miniaturized laboratory-on-chip systems promise rapid, sensitive, and multiplexed detection of biological samples for medical diagnostics, drug discovery, and high-throughput screening. Using microfabrication techniques and incorporating a unique design of transistor-based heating, researchers at the University of Illinois at Urbana-Champaign are further advancing the use of silicon transistor and electronics into chemistry and biology for point-of-care diagnostics.

Secret of scent lies in molecular vibrations

January 30, 2013 4:25 pm | News | Comments

In a study designed to find out how smell is written into a molecule’s structure, scientists in England tested whether changing how a molecule vibrates on a nanoscale changes its smell. They found that molecular vibrations, rather than molecular shape, give substances their distinct smell.

CAMS used to determine biological fate of silica nanoparticles

January 4, 2013 9:48 am | News | Comments

In a study published in Nano Letters, Lawrence Livermore National Laboratory (LLNL)'s Mike Malfatti, Heather Palko, Ed Kuhn, and Ken Turteltaub report on accelerator mass spectrometry measurements used to investigate the relationship between administered dose, pharmacokinetics (PK), and long-term biodistribution of carbon 14-labeled silica nanopartocles in vivo.

Improving the accuracy of cancer diagnoses

December 26, 2012 8:41 am | by Anne Trafton, MIT News Office | News | Comments

Tiny calcium deposits can be a telltale sign of breast cancer. However, in the majority of cases these microcalcifications signal a benign condition. A new diagnostic procedure developed at Massachusetts Institute of Technology and Case Western Reserve University could help doctors more accurately distinguish between cancerous and noncancerous cases.

Agilent, Spain institute partner on systems biology

October 30, 2012 1:40 pm | News | Comments

Agilent Technologies, Inc.and Spain’s Centre for Omic Sciences this week announced that they will collaborate on mass spectrometry and nuclear magnetic resonance-based metabolomics, and automation applied to research in integrated systems biology.

Measuring molecules with the naked eye

October 26, 2012 1:36 pm | News | Comments

When someone develops liver cancer, the disease introduces a very subtle difference to their bloodstream, increasing the concentration of a particular molecule by just 10 parts per billion. That small shift is normally difficult to detect without sophisticated equipment, but new lab-on-a-chip technology designed at Brigham Young University can reveal the presence of ultra-low concentrations of a target molecule.

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