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Near-infrared analysis quantifies powder drying process

February 23, 2012 9:41 am | White Papers

Modern process analytical technologies (PAT), a recent initiative of the U.S. Food & Drug Administration, are helping to move pharmaceutical manufactures to more scientifically rigorous production monitoring standards. Bruker Optics has developed methods to use near-infrared (NIR) analysis to meet these standards, and in a recent white paper details how a MATRIX-F instrument can determine moisture/solvent content during the common practice of drying powder in a fluid bed.

Crystallization monitoring adopts science-based quality control

February 23, 2012 9:36 am | White Papers

The U.S. Food & Drug Administration has been introducing manufacturing control practices that encourage pharmaceutical makers to move away from empirical standards. One example of this push for quantified process monitoring is crystallization, a process crucial in drug production. A Bruker Optics white paper describes how this can be done scientifically using a MATRIX-F spectrometer.

Focal plane arrays enable FT-IR microscopy

February 23, 2012 9:31 am | White Papers

The recent addition in recent years of focal plane array detectors to Fourier transform infrared (FT-IR) spectrometers has allowed the instrument to obtain much richer spectra, up to 16,000 pixels/spectra simultaneously. The heightened capabilities have positioned FT-IR to assume a greater role in a variety of laboratory imaging tasks traditionally reserve for conventional microscopes. A new white paper from Bruker Optics describes some of these applications.

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FT-IR spectroscopy rapidly acquires protein structure

February 23, 2012 9:22 am | White Papers

Proteins have become more important as active drugs in pharmaceuticals, such as therapeutic antibodies, and in the course of development the conformational changes of proteins and peptides must be determined. Typically, size-exclusion chromatography or circular dichroism spectroscopy is used for the prediction of the protein secondary structure, but, as described in a recent white paper from Bruker Optics, Fourier transform infrared (FT-IR) spectroscopy is much faster, acquiring information within one minute.

Study helps reveal origin of photosynthesis

February 23, 2012 6:44 am | News | Comments

An international team led by evolutionary biologist and Rutgers University professor Debashish Bhattacharya has shed light on the early events leading to photosynthesis. In sequencing the 70 million base pair nuclear genome of the ancient one-celled alga Cyanophora , the team was able to trace the origin of the underlying mechanics of photosynthesis further than ever before.

First results from large-scale molecular science R & D effort released

February 23, 2012 6:28 am | News | Comments

The TRR 61 project has been keeping about 150 scientists in Germany and China busy since 2008. The goal is to understand how large natural systems, such as biorganisms are assembled from numerous diverse small molecular structures. The first papers from the first stage of the project, which looks at self-assembly mechanisms, have recently been published.

Imaging technique can 'out run' damage from X-ray radiation

February 21, 2012 5:36 am | News | Comments

X-ray crystallography has become crucial to modern biological imaging, but large single crystals for high-quality data acquisition are difficult to grow. Plus, radiation damages delicate samples. A new technique, femtosecond diffraction imaging, could solve both problems at once and still deliver high-quality images.

Multi-element detectors greatly accelerate FT-IR image acquisition

February 21, 2012 5:31 am | White Papers

Infrared spectroscopy has been used in combination with traditional microscopy for more than 25 years, but has always been extremely time-consuming, requiring hours to resolve a sample area less than one square millimeter. The addition of multi-element detectors, along with Fourier transform technology, as described in a recent Bruker Optics white paper, enables a detection to assess all points on an image simultaneously, saving considerable time.

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Near-infrared spectrometry speeds up fats and oil analyses

February 21, 2012 5:26 am | White Papers

Labeling requirements for fats and oils under U.S. Food & Drug Administration guidelines are stringent. Values for iodine, free fatty acids, anisidine value, and even trans fatty acids are all mandatory. According to a recent white paper from Bruker Optics, the traditional analyses for these substances are designed for just one specific parameter and tend to be tedious. Near-infrared (NIR) spectrometry can identify multiple components with a single, fast measurement.

Bruker’s NIR spectrometers troubleshoot fermentation analysis

February 21, 2012 5:21 am | White Papers

High-performance liquid chromatography (HPLC) is the most widely used method for monitoring industrial-scale fermentation. But HPLC requires a lot of time, a high degree of skill, and can be expensive in the long-term. In addition, it can only analyze soluble components. Near-infrared (NIR) spectrometry, as detailed in a Bruker Optics white paper, can perform the same analysis with no waste and much greater speed.

NIR spectroscopy solves blending bottleneck for alcohol analysis

February 21, 2012 5:09 am | White Papers

Because of both strict government specification and tax rates, distillers must be sure their finished products contain the correct alcohol content. Near-infrared (NIR) spectroscopy solutions from Bruker Optics, as detailed in a recent white paper, can ease this common bottleneck for laboratory analysis, which typically involves the time-consuming and potentially inaccurate density meter analyzer method.

Corn grain quality quantified with near-infrared spectroscopy

February 21, 2012 5:03 am | White Papers

The largest expense to a distillery or a fuel ethanol plant, corn's value is highly contingent on its quality, especially with regard to moisture. However, the grain goes largely unmonitored through both industries. A new white paper from Bruker Optics details the steps by which near-infrared (NIR) spectroscopy can be used to quickly identify and verify moisture targets for corn grain, as well other important metrics such as oil content.

Ruminant calibration package lets Bruker FT-NIR optimize recipes

February 21, 2012 4:58 am | White Papers

International NIR Global Operating Technologies (INGOT) is a set of universal near-infrared (NIR) calibrations for the analysis of raw materials and finished products in the feed industry. A new white paper from Bruker Optics details how INGOT packages for Bruker's MPA and Matrix-I Fourier transform NIR (FT-NIR) spectrometers can be used to optimize recipes and account for parameters such as moisture, oil, protein, fiber, and ash.

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Calibrations can transfer from a monochromator NIR system to the MPA

February 21, 2012 4:52 am | White Papers

Building calibration data takes effort, which is why many laboratories stay with older monochromator-based near-infrared (NIR) instruments instead of upgrading to more accurate Fourier transform-based systems (FT-NIR). A recent white paper from Bruker Optics details the possibility of transferring old calibrations from a monochromator system to an FT-NIR system such as Bruker's MPA.

Iodine value of edible oil, monitored with FT-NIR

February 21, 2012 4:44 am | White Papers

Bruker Optics has published a method for on-line monitoring of edible fats and oils. Iodine value is important to these substances because it affects the viscosity and susceptibility to oxidation. Performed by a Fourier transform near-infrared spectrometer coupled with specially designed fiber optic probes, the methodology described in a recent Bruker Optics white paper speeds up analysis, reduces production down time, and achieves product consistency.

X-ray CT scans reveals underground world of plant roots

February 20, 2012 9:34 am | News | Comments

Plant and computer scientists can now study the underground world of plants with more accuracy and clarity thanks to the adaption of X-ray micro computed tomography (micro-CT). The method has been used in the U.K. to examine the shape and branching patterns of roots in soil. The new technique should improve the chances of breeding better crop varieties and increasing yields.

Chemists mimic nature to expand the range of biosensors

February 15, 2012 4:11 am | News | Comments

Biosensors used in medical diagnostics are typically very specific, detecting within a fixed dynamic ranges. Researchers recently designed a new type of biosensor that copies nature’s approach, which is to employ many different sensors all looking for a common target over a wide range.

Plants use circadian rhythms to prepare for battle with insects

February 14, 2012 9:45 am | News | Comments

According to a recent Rice University study, plants make predawn preparations to fend off hungry caterpillars. Using powerful genetic analysis tools that allow them to monitor precisely the accumulation of certain hormones, researchers found that plant can anticipate events and respond to them with the help of circadian-regulated genes.

Link found between sodium, calcium, and a beating heart

February 13, 2012 1:46 pm | News | Comments

Recent studies using the Canadian Light Source synchrotron have revealed, for the first time, one of the molecular mechanisms that regulates the beating of heart cells by controlling the movement of sodium in out of the cells—and what calcium has to do with it.

Mitosis mystery: How chromosomes align perfectly in a dividing cell

February 13, 2012 5:22 am | by Nicole Giese Rura | News | Comments

It’s a mystery that has puzzled researchers for years: In a cell undergoing mitotic cell division, what internal signals cause its chromosomes to align on a center axis? Using fluorescence microscopy, Tomomi Kiyomitsu at the Whitehead Institute for Biomedical Research found the solution by observing something no one had noticed before.

Nervous system wiring may rely on just a handful of genes, proteins

February 12, 2012 4:42 pm | News | Comments

In a startling finding, researchers at the Salk Institiute have recently discovered that only a few proteins on the leading edge of a motor neuron's axon—its outgoing electrical "wire"—and within the extracellular soup it travels through guide the nerve as it emerges from the spinal cord.

Collaboration adds timing capability to living cell sensors

February 9, 2012 3:25 am | News | Comments

Individual cells modified to act as sensors using fluorescence are already useful tools in biochemistry, but now they can add good timing to their resumé, thanks in part to NIST. With the added capability to track the timing of dynamic biochemical reactions, cell sensors become more useful for many studies, such as measurements of protein folding or neural activity.

Brooks Automation, Scripps initiate imaging development partnership

February 8, 2012 10:00 am | News | Comments

An agreement to complete the development of a microplate imaging system invented by Scripps Research Institute engineers has been formed between the institute and Brooks Life Science Systems, a division of Brooks Automation, Inc. The system is intended for biotech and pharmaceutical companies performing high-throughput screening.

The reason why bad immunity genes persist

February 7, 2012 5:54 pm | News | Comments

Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs—even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.

Entire genome of extinct human decoded from fossil

February 7, 2012 12:49 pm | News | Comments

In 2010, Svante Pääbo and his colleagues decoded the genetic information from small fragment of a human finger bone discovered in Denisova Cave in southern Siberia. Now, the Leipzig, Germany-based team has develop sensitive techniques to allow them to sequence every position in the genome of this extinct group of humans using less than 10 mg of bone.

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