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Chemists debunk myth about powerful drug amphotericin

January 16, 2012 12:04 pm | News | Comments

An elegant approach to synthesizing amphotericin B, which has been used extensively as an antifungal for more than 50 years, has allowed researchers to learn its elusive mode of action. The finding may change drug development directions and improve antifungal treatments, but there is still a downside to the drug.

Automated imaging to greatly speed whole-brain mapping efforts

January 16, 2012 7:52 am | by Peter Tarr | News | Comments

Until now, methods to obtain highly detailed anatomical images of whole brains have been painstakingly slow and available only to a handful of specialized research teams. Neuroscientists at Cold Spring Harbor Laboratory have adapted two-photon microscopy to open 3D whole brain mapping to a much wider field of researchers.

‘Bubblegram’ imaging reveals inner working of viruses

January 12, 2012 10:49 am | News | Comments

Despite cryo-electron microscopy’s ability to resolve viruses, scientists have been unable to clearly visualize structures inside of viruses because radiation is used to image them. Reserachers at the National Institutes of Health invented a new technique that turns this radiation into an imaging asset.


Company announces low-cost DNA decoding machine

January 12, 2012 10:05 am | by Malcolm Ritter, AP Science Writer | News | Comments

Biotechnology company Life Technologies Corp. announced it has developed a machine to decode an individual's DNA in a day for $1,000, a long-sought price goal for making the genome useful for medical care.

Lab method uses mass spectrometry to detect staph infections

January 12, 2012 5:25 am | News | Comments

Researchers from the Georgia Institute of Technology and the Centers for Disease Control and Prevention have developed a new laboratory test that can rapidly identify the bacterium responsible for staph infections. This new test takes advantage of unique isotopic labeling combined with specific bacteriophage amplification to rapidly identify Staphylococcus aureus .

Integrated nanopore detector could revolutionize DNA sequencing

January 6, 2012 1:19 pm | by Peter Reuell, Harvard University | News | Comments

Scientists in a Harvard University lab have invented a tiny device designed to read the minute electrical changes produced when DNA strands are passed through tiny holes—called nanopores—in an electrically charged membrane. The device can do this quickly and cheaply offering the possibilities of millions of arrays.

Device finds cancer cells before they become tumors

January 5, 2012 11:53 am | News | Comments

Currently, physicians use computed tomography or magnetic resonance imaging scans for melanoma cancer detection. Soon, however, commercial production of a device invented by University of Missouri researchers that measures melanoma using photoacoustics, or laser-induced ultrasound, will begin. The device will be available to scientists for cancer studies.

New endoscope can image the interior of a single cell

December 21, 2011 11:28 am | by Lynn Yarris | News | Comments

A team of researchers from Lawrence Berkeley National Laboratory and the University of California, Berkeley have created an endoscopy device that can capture high-resolution optical images of the interior of a single living cell without injuring or damaging that cell.


Quantum computing could make electron-diamond imager work

December 20, 2011 5:28 am | News | Comments

An innovative design for a small-volume molecular imaging instrument by University of Pittsburgh physicists has been hampered by a major question: How does one measure a magnetic field accurately using the resonance of single electrons within a diamond crystal? It’s too difficult with normal computers, but the scientists think they may now have an answer.

Scientists discover second-oldest gene mutation

December 16, 2011 7:31 am | News | Comments

A new study has identified a gene mutation that researchers estimate dates back to 11,600 B.C., making it the second oldest human disease mutation yet discovered. Researchers say that although the mutation, which causes a rare vitamin deficiency, is found in vastly different ethnic populations, it originated in a single, prehistoric individual and was passed down to that individual's descendents.

Taxi driver training changes brain structure

December 8, 2011 7:12 pm | News | Comments

Those who want to be London taxi drivers must acquire what's known as "the Knowledge," learning 25,000 complicated streets over a time span of three to four years. According to a recent study, the experience actually changes the very structure of the trainees’ brains.

Evolution reveals a link between DNA and protein shape

December 8, 2011 6:44 pm | News | Comments

Fifty years after the pioneering discovery that a protein's 3D structure is determined solely by the sequence of its amino acids, an international team of researchers has taken a major step toward predicting the structure of a protein from its sequence alone.

Bioelectrical alterations cause tadpoles to grow eye in back, tail

December 8, 2011 2:59 am | News | Comments

Researchers at Tufts University were surprised to discover that when they manipulated the membrane voltage in a tadpole’s back and tail, it caused the growing animal to develop eyes in those locations. It could be the first recorded instance of deliberate organogenesis through altered bioelectric communication.


New biometric data standard adds DNA and footmarks

December 7, 2011 8:11 am | News | Comments

Once limited to fingerprints, faces, and irises, forensic scientists can now have shared access to a greatly expanded set of biometric recently approved and standardized by NIST. It is the first international standard for the exchange of DNA data.

Frogs' amazing leaps due to springy tendons

November 16, 2011 6:49 am | News | Comments

The frogs jumping in Calaveras County, Calif., might be special, but even ordinary frogs can leap several times farther than their physiology would seem to allow. Using high-speed X-ray video technology, a Brown University research has determined that the frog’s tendons are what gives it the ability to soar.

Perfect micro rings can’t escape from ‘absorbing state’

November 15, 2011 11:20 am | News | Comments

Scientists refer to a state that a system that cannot escape from as an absorbing state. In a surprise finding, researchers in Germany have succeeded in building a simple biological model system of an absorbing state consisting of only three components: fibers, motor proteins and cross-linking molecules.

Even the cleanest wastewater contributes to “super bacteria”

November 15, 2011 4:09 am | News | Comments

A new University of Minnesota study has revealed that the release of treated municipal wastewater—even wastewater treated by the highest-quality treatment technology—can have a significant effect on the quantities of antibiotic-resistant bacteria, often referred to as "super bacteria", in surface waters.

Bats can quickly change their ear shapes, aiding biosonar abilities

November 14, 2011 8:32 am | News | Comments

Within just one tenth of a second, certain species of bat are able to change their outer ear shapes, transforming the animals’ ultrasonic hearing pattern. Using a combination of high-speed stereo vision and high-resolution tomography, researchers have reconstructed the 3-D geometries of these dramatic physical changes.

Leica, German institutes jointly pursue super-resolution

November 11, 2011 9:12 am | News | Comments

Leica Microsystems has signed an agreement with the Max Planck Society and the German Cancer Research Center for the development of the next generation of super-resolution STED (stimulated emission depletion) microscopy. The new STED nanoscopy will provide improved spatial resolution over confocal microscopy in living cells.

Plasma bags to greatly benefit live cell treatments

November 11, 2011 5:30 am | News | Comments

Using plasmas, researchers have found that sealed plastic bags can be modified at atmospheric pressure so that human cells can adhere to and reproduce on their walls. Cell culture bags of this kind may eventually replace the Petri dishes used today.

Bedside test finds awareness in vegetative brains

November 10, 2011 4:52 am | by Malcolm Ritter, AP Science Writer | News | Comments

In recent years, scientists have learned that some patients believed to be in a vegetative state actually have some awareness. A new study suggests a portable brain monitor can detect signs of this, perhaps making it possible someday for doctors to easily double-check the diagnosis at the bedside.

Cave painters were realists, DNA study finds

November 8, 2011 3:46 am | by Alicia Chang, AP Science Writer | News | Comments

Prehistoric paintings of horses found in caves through France have depicted black, brown, or spotted horses, leading to speculation about whether the artists were dreaming up patterns or painting what they saw. DNA analysis of fossilized horse bones and teeth suggest they were more like da Vinci than Dali.

New device uses light to screen for melanoma

November 7, 2011 9:08 am | by Matthew Perrone, AP Health Writer | News | Comments

The U.S. Food and Drug Administration recently approved a first-of-its-kind device, called MelaFind, that makes detailed digital images of skin growths and uses a computer to analyze them for signs of cancer, offering a sort of second opinion to doctors.

Analysis reveals malaria as ancient, adaptive and persistent foe

November 3, 2011 11:18 am | News | Comments

One of the most comprehensive analyses yet done of the ancient history of insect-borne disease concludes for the first time that malaria is not only native to the New World, but it has been  present long before humans existed and has evolved through birds and monkeys.

Nanocomposite brain probe causes less scarring

November 3, 2011 6:54 am | News | Comments

Inspired by the skin of the sea cucumber, which is normally soft and flexible but becomes rigid in self defense, biomedical engineers at Case Western Reserve University have built a nanostructured polymer mesh that is firm enough to reach the cortex, but begins unlinking in water, causing less brain damage.

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