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Nanocosmos of cells under the magnifying glass

August 26, 2014 3:56 pm | by Gunnar Bartsch, Julius-Maximilians-Universität Würzburg | News | Comments

Scientists in Germany have managed to take a unique look at the membranes of human cells using a new technique called dSTORM: direct stochastic optical reconstruction microscopy. This is a specific form of high-resolution fluorescence microscopy, and it makes individual saccharified proteins and lipids visible at the molecular level.

A surprising new role for natural killer T cells

August 25, 2014 9:25 am | News | Comments

In the past, immune cells were clearly divided into innate cells, which respond to attacks in a non-specific way, and adaptive cells, which learn to recognize new antigens and gain the ability to rapidly react to later attacks. Researchers at RIKEN in Japan have discovered that is not always the case, having found that killer T cells previously thought to be innate, and thus short-lived, can remain in the lung for up to nine months.

NMR using Earth’s magnetic field

August 20, 2014 8:19 am | by Rachel Berkowitz, Lawrence Berkeley National Laboratory | News | Comments

Earth’s magnetic field, a familiar directional indicator over long distances, is routinely probed in applications ranging from geology to archaeology. Now it has provided the basis for a technique which might, one day, be used to characterize the chemical composition of fluid mixtures in their native environments.

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New handheld device uses lasers, sound for melanoma imaging

August 7, 2014 9:39 am | News | Comments

Melanoma is the fifth most common cancer type in the United States. A new handheld device may help diagnosis and treatment efforts for the disease. It uses lasers and sound waves and is the first that can be used directly on a patient to accurately measure how deep a melanoma tumor extends into the skin.

R&D Life Sciences Overview

August 6, 2014 10:07 am | by Lindsay Hock, Managing Editor | Thermo Fisher Scientific, Shimadzu Scientific Instruments, Protea Biosiences , Agilent Technologies Inc. | Articles | Comments

Life science researchers are benefiting from easy-to-use, ultra-fast, automated and integrated platforms that address specific application needs. These platforms combine hardware, software and reagents into integrated, push-button analysis systems capable of transforming workflows which once took several days into minutes.

Enhanced Sample Prep

August 6, 2014 9:21 am | by Lindsay Hock, Managing Editor | Articles | Comments

Sample preparation is a critical step in the analytical process. Studies report that sample prep can represent about 60% of a laboratory technician’s time and also forms one of the principal sources of error. Many techniques to conduct sample prep are available to researchers, such as filtration, digestion, dialysis, liquid/liquid extraction and solid phase extraction.

Scientists solve 2,000-year-old Terracotta Army mystery

August 4, 2014 10:12 am | News | Comments

China's first emperor ordered the building of a glorious underground palace complex, mirroring his imperial capital, that would last for an eternity. Protecting this underworld palace was his imperial guard, cast in terracotta. Efforts to preserve the 1974 archaeological find have been hampered by failures to pinpoint the binding material used in applying pigments to the soldiers. Mass spectrometry studies have recently solved this mystery.

New paper describes how DNA avoids damage from UV light

July 31, 2014 11:42 am | by Evelyn Boswell, Montana State Univ. | News | Comments

In the same week that the U.S. surgeon general issued a lengthy report about the dangers of skin cancer, researchers at Montana State Univ. published a paper breaking new ground on how DNA responds when exposed to ultraviolet (UV) light. The study, made possible by femtosecond lasers used for ultrafast spectroscopy, showed how DNA transfers electrons when excited by UV light.

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Breakthrough in understanding of important blood protein

July 31, 2014 10:07 am | News | Comments

The human body contains a unique protein that has the unusual property of destroying itself after a few hours of existence. Called PAI-1, it affects many physiological functions, including the dissolving of coagulated blood. Recent research in Denmark has shed light on how PAI-1 changes shape. This is considered important because the protein has one of the largest shape changes in the known world of proteins.

Ames Lab home to first-in-nation DNP-NMR instrument

July 31, 2014 9:51 am | by Breehan Gerleman Lucchesi, Communications Specialist, Ames Laboratory | News | Comments

Ames Laboratory is now the home to a dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance (NMR) spectrometer that helps scientists understand how individual atoms are arranged in materials. Ames Laboratory’s DNP-NMR is the first to be used for materials science and chemistry in the U.S.

New assay tool characterizes plant sugar transporters

July 28, 2014 4:54 pm | News | Comments

A powerful new tool that could help advance the genetic engineering of “fuel” crops bioenergy, has been developed by researchers with the Joint BioEnergy Institute. Their new, unique assay enabled them to analyze nucleotide sugar transporter activities in Arabidopsis, a promising source of plant biomass, and characterize a family of six nucleotide sugar transporters that has never before been described.

Chemist develops x-ray vision for quality assurance

July 25, 2014 6:57 am | by Iben Julie Schmidt, Technical Univ. of Denmark | News | Comments

A new method that uses x-rays for the rapid identification of substances present in an indeterminate powder has been developed by a scientist in Denmark. The new technique has the capacity to recognize advanced biological molecules such as proteins, which makes it potentially important in both food production and the pharmaceutical industry, where it opens up new opportunities for the quality assurance of protein-based medicines.

Instrument enables high-speed chemical imaging of tissues

July 23, 2014 8:06 am | News | Comments

A research team from NIST, working with the Cleveland Clinic, has demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures." The new NIST technique is an advanced form of the widely used spontaneous Raman spectroscopy, but one that delivers signals that are 10,000 times stronger than obtained from spontaneous Raman scattering.

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Reconstructing an animal’s development cell by cell

July 21, 2014 9:36 am | News | Comments

Janelia Research Campus experts have built a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell. Using image data obtaining using a sophisticated form of light sheet microscopy, the tool can track the movement of cells in an animal’s body in 3-D.

Researchers create new method to draw molecules from live cells

July 18, 2014 12:30 pm | by Jeannie Kever, Univ. of Houston | News | Comments

Most current methods of identifying intracellular information result in the death of the individual cells, making it impossible to continue to gain information and assess change over time. Using magnetized carbon nanotubes, scientists in Texas have devised a new method for extracting molecules from live cells without disrupting cell development.

Powerful molecular sensor boosts optical signal by 100 billion times

July 15, 2014 4:45 pm | by Mike Williams, Rice Univ. | News | Comments

Scientists at Rice Univ. have created a unique sensor that amplifies the optical signature of molecules by about 100 billion times. The new imaging method uses a form of Raman spectroscopy in combination with an intricate but mass reproducible optical amplifier. Newly published tests found the device could accurately identify the composition and structure of individual molecules containing fewer than 20 atoms.

Researchers invent nanotech microchip to diagnose type-1 diabetes

July 14, 2014 9:22 am | News | Comments

A cheap, portable, microchip-based test for diagnosing type-1 diabetes could speed up diagnosis and enable studies of how the disease develops. Handheld microchips distinguish between the two main forms of diabetes mellitus, which are both characterized by high blood-sugar levels but have different causes. Until now, making the distinction has required a slow, expensive test available only in sophisticated healthcare settings.

Food allergies: A new, simple method to track down allergens

July 8, 2014 1:20 pm | News | Comments

Scientists in Switzerland have developed a fast and accurate method for determining exactly which proteins cause allergies to milk. The novel approach, which is based on a specialized form of laser desorption-ionization mass spectrometry, is highly personalized and can extend to other foods as well.

Automated dynamic light scattering benefits protein-protein quantifications

July 1, 2014 2:08 pm | Application Notes

Wyatt Technology Corp. has highlighted a recently authored study that outlines the advantages of quantifying protein-protein interactions (PPI) using automated dynamic light scattering (DLS) in high-throughput screening (HTS) mode to identify promising candidates for drug-like properties. Automated DLS helps establish the suitability of formulations before entering extended stability studies.

New light-sensitive protein enables simpler, more powerful optogenetics

June 30, 2014 9:14 am | by Anne Trafton, MIT | News | Comments

Optogenetics relies on light-sensitive proteins that can suppress or stimulate electrical signals within cells. This technique requires a light source to be implanted in the brain, where it can reach the cells to be controlled. Massachusetts Institute of Technology engineers have now developed the first light-sensitive molecule that enables neurons to be silenced noninvasively, using a light source outside the skull.

Fast, portable device for “on-the-go” cocaine testing

June 25, 2014 8:39 am | News | Comments

Testing for cocaine and other drugs usually involves two steps: a quick on-site prescreen, and then a more accurate confirmatory test at a distant laboratory. This process can take days or weeks—but that’s too long in many cases where public safety is at risk. Now, researchers report development of a backpack-sized device that can perform highly accurate and sensitive tests anywhere within 15 min.

Analytic technique offers arson investigators faster, more accurate results

June 18, 2014 9:04 am | by James Burrus, NIST | News | Comments

A research group at NIST has demonstrated a new method for detecting ignitable liquids that could change the way arson fires are investigated. The new process for analyzing debris for traces of fire accelerants is faster and more accurate than conventional methods and produces less waste.

Dynamic spectroscopy duo

June 17, 2014 1:34 pm | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

From allowing our eyes to see, to enabling green plants to harvest energy from the sun, photochemical reactions are ubiquitous and critical to nature. Photochemical reactions also play essential roles in high technology. Using photochemical reactions to our best advantage requires a deep understanding of the interplay between the electrons and atomic nuclei within a molecular system after that system has been excited by light.

Pittcon to sponsor International Year of Light

June 16, 2014 10:54 am | News | Comments

The Pittcon Organizing Committee, which holds the Pittcon Conference and Exposition each year, will participate in the International Year of Light initiative at the Associate Sponsor level. The United Nations General Assembly has proclaimed 2015 as the International Year of Light and Light-based Technologies. The sponsorship effort will include a variety of focused workshops and short courses in the coming year.

Music under the microscope

June 11, 2014 9:01 am | News | Comments

Researchers in Germany have converted the frequencies of droplets flowing through thin channels into musical notes. This is more than just a gimmick: The fact that droplets can be controlled so precisely that they become musical instruments means they are also of interest with regard to medical diagnostics applications.

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