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The Lead

Building the Next Generation of Raman

October 29, 2014 9:40 am | by Brian Davies, VP Marketing and Product Development, Chemical Analysis Div., Thermo Fisher Scientific | Thermo Fisher Scientific | Articles | Comments

Given today’s widespread use of Raman spectroscopy, it can be hard to believe Raman was a highly specialized analytical technique for most of its history. The technique’s potential was recognized from the beginning: When Raman scattering was first observed in 1928, it was widely believed to be one of the most important scientific discoveries of the 20th century to date.

“Sticky” ends start synthetic collagen growth

October 28, 2014 8:12 am | by Mike Williams, Rice Univ. | News | Comments

Rice Univ. researchers have delivered a scientific one-two punch with a pair of papers that...

Remote Monitoring and Diagnostics to Improve ROI

October 27, 2014 10:19 am | by Andy Wight, Director, Service Product Portfolio, Global Services, AB Sciex | Articles | Comments

As a laboratory technician or director, knowing the current status of your instrument or sample...

Simplifying Oil Content Measurements for the Petrochemical Industry

October 22, 2014 9:32 am | by Sandy Rintoul, Executive Vice President, Wilks-A Spectro Inc. Company | Articles | Comments

Measuring oil content in wastes is nothing new to the petrochemical industry. Whether it’s...

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Solutions in Search of Problems: Spectroscopy Takes Flight

October 20, 2014 10:07 am | by Yvette Mattley, PhD, Senior Applications Specialist and Rob Morris, Marketing Operations Manager, Ocean Optics | Ocean Optics | Articles | Comments

Spectral sensing is so pervasive that most take it for granted. Even miniature spectrometers have been embraced by late adopters. Yet, spectroscopy has moved beyond routine laboratory and test measurements to take on ever-more sophisticated applications. In this article we explore how familiar spectral sensing technologies—and new ways to exploit them—are today addressing a wider range of measurement problems than ever.

Lab-on-a-chip for early diagnosis of cancer

October 8, 2014 8:09 am | by Brendan M. Lynch, KU News Service | News | Comments

Scientists have been laboring to detect cancer and a host of other diseases in people using promising new biomarkers called “exosomes.” Indeed, Popular Science magazine named exosome-based cancer diagnostics one of the 20 breakthroughs that will shape the world this year. Exosomes could lead to less invasive, earlier detection of cancer, and sharply boost patients’ odds of survival.

Researchers pinpoint mechanism for aroma formation in wine

October 3, 2014 9:35 am | News | Comments

The majority of wines are produced from around 20 different types of grape, all of which have their own typical aroma. This is due to the terpenes, a diverse category of chemical substances including cholesterol and estrogen. Scientists have now identified two enzymes that determine the terpene content, and thus the aroma intensity, of grapes. The findings could play an important role in the future development of grape varieties.

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NIH awards UC Berkeley $7.2 million to advance brain initiative

October 2, 2014 8:28 am | by Robert Sanders, UC Berkeley | News | Comments

The National Institutes of Health this week announced its first research grants through President Barack Obama’s BRAIN Initiative, including three awards to the Univ. of California, Berkeley, totaling nearly $7.2 million over three years. The projects are among 58 funded in this initial wave of NIH grants, involving 100 researchers and a total of $46 million in fiscal year 2014 dollars alone.

Agilent to collaborate with Univ. of Toronto on metabolomics solutions

October 2, 2014 7:57 am | News | Comments

A collaboration has been announced between Agilent Technologies and the Univ. of Toronto’s Donnelly Centre for Cellular and Biomolecular Research to produce a comprehensive metabolomics multiple-reaction monitoring library and methodology, using Agilent’s Infinity 1290 UHPLC, 6460 triple quadrupole mass spectrometry system, and MassHunter Software. The goal is to accelerate quantification of hundreds of metabolically important compounds.

New method helps portable detection of potent “bath salts” drugs

October 1, 2014 11:25 am | News | Comments

Despite being outlawed in 2012 in the U.S., the synthetic drugs known as "bath salts" are still readily available in some retail shops, on the Internet and on the streets. To help law enforcement, scientists are developing low-cost, disposable, mercury-free electrodes that could be the basis for the first portable, on-site testing device for identifying the drugs.

Join the best of the best in innovation

October 1, 2014 8:57 am | by Lindsay Hock, Managing Editor | News | Comments

The 52nd annual R&D 100 Awards event will present a series of panel discussions featuring today’s top technological minds revealing their secrets for innovation. Draw inspiration from these leading experts as they discuss technology-driven strategies for transforming your ideas into excellence.

Fat molecules influence form, function of key photosynthesis protein

September 30, 2014 7:48 am | by Elizabeth K. Gardner, Purdue Univ. | News | Comments

A mysterious space within a protein critical to photosynthesis is filled with fat molecules that influence both the protein’s architecture and electrical properties, according to two recent studies. Researchers studied the atomic structure of, and electrical interactions within, the cytochrome bf complex, a protein complex central to the transport of electrons within membranes of a plant cell, a critical step in photosynthesis.

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Cell sorting method separates 10 billion cells in 30 minutes

September 26, 2014 9:42 am | News | Comments

Almost all of today’s previously existing cell-sorting methods rely on what is called a single-cell analysis platform. A researcher in Hawaii took a different approach, inventing a bulk method that sorts different cell populations by tuning their solubility. Instead of targeting individual features, the  measurement principle sorts cells by differentiating their characteristic surface free energies.

Protein “map” could lead to potent new cancer drugs

September 26, 2014 8:55 am | News | Comments

Chemists in the U.K. have gained fresh insights into how a disease-causing enzyme makes changes to proteins and how it can be stopped. The scientists hope their findings will help them to design drugs that could target the enzyme, known as N-myristoyltransferase (NMT), and potentially lead to new treatments for cancer and inflammatory conditions.

Technology tracks tiniest pollutants in real time

September 26, 2014 8:23 am | by Brett Israel, Georgia Institute of Technology | News | Comments

Researchers may soon have a better idea of how tiny particles of pollution are formed in the atmosphere. These particles, called aerosols, are hazardous to human health and contribute to climate change, but researchers know little about how their properties are shaped by chemical reactions in the atmosphere. Unraveling this chemistry could someday lead to more effective policies to protect human health and the Earth’s climate.

Clues to how people bounce back from surgery

September 25, 2014 10:48 am | News | Comments

One of the big frustrations of surgery is that little indicates whether the patient is a fast or slow healer, someone who feels normal in a week or is out of work for a month with lingering pain and fatigue. Now Stanford Univ. researchers have discovered that right after surgery, patients' blood harbors clues about how fast they'll bounce back. And it has to do with the activity of certain immune cells that play a key role in healing.

Graphene sensor tracks down cancer biomarkers

September 19, 2014 4:33 pm | News | Comments

A new, ultrasensitive biosensor made from graphene has been used to detect molecules that indicate an increased risk of developing cancer. The biosensor has been shown to be more than five times more sensitive than bioassay tests currently in use, and was able to provide results in a matter of minutes, opening up the possibility of a rapid, point-of-care diagnostic tool for patients.

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Nanoscience makes your wine better

September 18, 2014 1:13 pm | by Anne-Mette Siem, Aarhus Univ. | News | Comments

One sip of a perfectly poured glass of wine leads to an explosion of flavors in your mouth. Researchers in Denmark have now developed a nanosensor that can mimic what happens in your mouth when you drink wine. The sensor, which uses gold nanoparticles to act as a “mini-mouth”, measures how you experience the sensation of dryness in the wine.

Scientists discover RNA modifications in some unexpected places

September 16, 2014 11:40 am | by Matt Fearer, Whitehead Institute | News | Comments

Deploying sophisticated high-throughput sequencing technology, a team of Whitehead Institute and Broad Institute researchers have collaborated on a comprehensive, high-resolution mapping that confirms a post-transcriptional RNA modification called pseudouridylation does indeed occur naturally in messenger RNA. This is somewhat surprising finding using a new quantitative sequencing method.

EEG study findings reveal how fear is processed in the brain

September 16, 2014 8:51 am | News | Comments

Building on previous animal and human research, a new study has identified an electrophysiological marker for threat in the brain. The findings illustrate how fear arises in the brain when individuals are exposed to threatening images, and the study is the first to separate emotion from threat by controlling for the dimension of arousal, the emotional reaction provoked, whether positive or negative, in response to stimuli.

Novel method for portable detection of drugs

September 10, 2014 10:37 am | by American Chemical Society | News | Comments

Despite being outlawed in 2012 in the U.S., the synthetic drugs known as “bath salts”—which really aren’t meant for your daily bath—are still readily available in some retail shops, on the Internet and on the streets. To help law enforcement, scientists are developing a novel method that could be the basis for the first portable, on-site testing device for identifying the drugs.

Thermo Fisher Scientific teams with reference labs on new European food regulation

September 4, 2014 8:50 am | News | Comments

European laboratories testing food for dioxins now have lower-cost, smaller-footprint alternatives for confirming levels of toxic contaminants, thanks to a new European Union regulation. Thermo Fisher Scientific worked closely with national reference labs in the EU to support the development of the new regulation, which permits use of gas chromatograph-triple stage quadrupole mass spectrometers (GC-MS/MS) for confirmation.

Handheld scanner could aid complete removal of brain tumors

September 3, 2014 1:09 pm | News | Comments

Cancerous brain tumors are notorious for growing back despite surgical attempts to remove them, and for leading to a dire prognosis for patients. But scientists are developing a new way to try to root out malignant cells during surgery so fewer or none get left behind to form new tumors. The technology relies on a Raman scanner that can read injected nanoprobes.

Engineers develop new sensor to detect tiny individual nanoparticles

September 2, 2014 8:51 am | by Tony Fitzpatrick, Washington Univ. in St. Louis | News | Comments

A team of researchers in the U.S. and China have developed a new sensor that can detect and count nanoparticles, at sizes as small as 10 nm, one at a time. The researchers say the sensor, which is a Raman microlaser sensor in a silicon dioxide chip that does not need rare-earth ions to achieve high resolution, could potentially detect much smaller particles, viruses and small molecules.

Nanocosmos of cells under the magnifying glass

August 26, 2014 3:56 pm | by Gunnar Bartsch, Julius-Maximilians-Universität Würzburg | News | Comments

Scientists in Germany have managed to take a unique look at the membranes of human cells using a new technique called dSTORM: direct stochastic optical reconstruction microscopy. This is a specific form of high-resolution fluorescence microscopy, and it makes individual saccharified proteins and lipids visible at the molecular level.

A surprising new role for natural killer T cells

August 25, 2014 9:25 am | News | Comments

In the past, immune cells were clearly divided into innate cells, which respond to attacks in a non-specific way, and adaptive cells, which learn to recognize new antigens and gain the ability to rapidly react to later attacks. Researchers at RIKEN in Japan have discovered that is not always the case, having found that killer T cells previously thought to be innate, and thus short-lived, can remain in the lung for up to nine months.

NMR using Earth’s magnetic field

August 20, 2014 8:19 am | by Rachel Berkowitz, Lawrence Berkeley National Laboratory | News | Comments

Earth’s magnetic field, a familiar directional indicator over long distances, is routinely probed in applications ranging from geology to archaeology. Now it has provided the basis for a technique which might, one day, be used to characterize the chemical composition of fluid mixtures in their native environments.

New handheld device uses lasers, sound for melanoma imaging

August 7, 2014 9:39 am | News | Comments

Melanoma is the fifth most common cancer type in the United States. A new handheld device may help diagnosis and treatment efforts for the disease. It uses lasers and sound waves and is the first that can be used directly on a patient to accurately measure how deep a melanoma tumor extends into the skin.

R&D Life Sciences Overview

August 6, 2014 10:07 am | by Lindsay Hock, Managing Editor | Thermo Fisher Scientific, Shimadzu Scientific Instruments, Protea Biosiences , Agilent Technologies Inc. | Articles | Comments

Life science researchers are benefiting from easy-to-use, ultra-fast, automated and integrated platforms that address specific application needs. These platforms combine hardware, software and reagents into integrated, push-button analysis systems capable of transforming workflows which once took several days into minutes.

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