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The Lead

New tool on horizon for surgeons treating cancer patients

June 18, 2015 9:30 am | by Ron Walli, Oak Ridge National Laboratory | News | Comments

Surgeons could know while their patients are still on the operating table if a tissue is cancerous, according to researchers from Oak Ridge National Laboratory (ORNL) and Brigham and Women’s Hospital/Harvard Medical School. In Analytical and Bioanalytical Chemistry, a team led by ORNL's Vilmos Kertesz describes an automated droplet-based surface sampling probe that accomplishes in about 10 min what now routinely takes 20 to 30 min.

Keeping astronauts in space longer with better air, water

June 4, 2015 8:00 am | by American Chemical Society | News | Comments

As astronauts embark on increasingly ambitious space missions, scientists have to figure out how...

Chemists weigh intact virus mixture with mass spectrometer

June 3, 2015 7:41 am | by Jocelyn Duffy, Carnegie Mellon Univ. | News | Comments

Carnegie Mellon Univ. chemists have separated and weighed virus particles using mass...

Essential Instruments for Open-Access Environment

June 2, 2015 3:55 pm | by Russell Scammell,PhD, Group Leader, Physical Chemistry, Charles River Laboratories | Articles | Comments

Pharmaceutical companies, like other industries, face frequent and mounting requirements to...

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Solving streptide from structure to biosynthesis

May 18, 2015 7:31 am | by Princeton Univ. | News | Comments

Bacteria speak to one another using peptide signals in a soundless language known as quorum sensing. In a step towards translating bacterial communications, researchers at Princeton Univ. have revealed the structure and biosynthesis of streptide, a peptide involved in the quorum sensing system common to many streptococci.

Damming hemorrhagic diseases

May 11, 2015 8:50 am | by Univ. of Montreal | News | Comments

A potential mechanism to combat diseases caused by haemorrhagic fever viruses has been discovered by researchers at the Univ. of Montreal's Dept. of Biochemistry and Molecular Medicine. These diseases present a dramatic risk to human health as they often spread quickly and kill a high percentage of infected individuals, as demonstrated by the recent Ebola outbreaks.

Zinc deficiency linked to activation of Hedgehog signaling pathway

April 17, 2015 8:03 am | by Mary Martialay, Rensselaer Polytechnic Institute | News | Comments

Zinc deficiency, long associated with numerous diseases like certain cancers, can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute.

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Tailoring GPC/SEC to Today’s Applications

April 16, 2015 2:04 pm | by Stephen Ball, Product Marketing Manager, Nanoparticleand Molecular Characterization, Malvern Instruments | Articles | Comments

Gel permeation/size exclusion chromatography (GPC/SEC) is a vital analytical technique used to characterize synthetic and natural polymers, including biologically important macromolecules such as proteins and DNA. Evolving challenges tax the capabilities of traditional GPC/SEC and invite advances in the technology.

Mobile, Raman and NMR Drive New Technologies

April 16, 2015 1:42 pm | by Tim Studt | Articles | Comments

At the 66th annual Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy (Pittcon) this past March 7 – 13 in New Orleans, the spectroscopy- based new product introductions covered, quite literally, the entire analytical spectrum from the far-infrared to x-rays, along with Raman and mass spectrometry (MS) and nuclear magnetic resonance (NMR) products.

Shape-shifting molecule tricks viruses into mutating themselves to death

April 15, 2015 9:36 am | by Steve Koppes, Univ. of Chicago | News | Comments

A newly developed spectroscopy method is helping to clarify the poorly understood molecular process by which an anti-HIV drug induces lethal mutations in the virus’ genetic material. The findings from the Univ. of Chicago and the Massachusetts Institute of Technology could bolster efforts to develop the next generation of anti-viral treatments.

NMR “fingerprinting” for monoclonal antibodies

April 15, 2015 8:49 am | by NIST | News | Comments

NIST researchers have demonstrated the most precise method yet to measure the structural configuration of monoclonal antibodies, an important factor in determining the safety and efficacy of these biomolecules as medicines. Monoclonal antibodies are proteins manufactured in the laboratory that can target specific disease cells or antigens (proteins that trigger an immune reaction) for removal from the body.

Microsecond Raman imaging might probe cells, organs for disease

March 30, 2015 1:03 pm | by Emil Venere, Purdue Univ. | News | Comments

A vibrational spectroscopic imaging technology that can take images of living cells could represent an advanced medical diagnostic tool for the early detection of cancer and other diseases. High-speed spectroscopic imaging makes it possible to observe the quickly changing metabolic processes inside living cells and to image large areas of tissue, making it possible to scan an entire organ.

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Tips for Successful LC-MS: Keep the Sample In Focus

March 13, 2015 2:26 pm | by Vivek Joshi, PhD, EMD Millipore | Articles | Comments

Liquid chromatography-mass spectrometry (LC-MS) is taking over as an analytical technique of choice in diverse fields. While a LC-MS analyst may be tempted to rely on the most commonly used sample prep techniques, columns and mobile phases in his/her field, we show successful LC-MS demands these workflow elements be chosen with the physico-chemical properties of the analyte in mind.

Forbidden quantum leaps possible with high-res spectroscopy

March 2, 2015 11:27 am | by Nicole Casal Moore, Univ. of Michigan | News | Comments

A new twist on an old tool lets scientists use light to study and control matter with 1,000 times better resolution and precision than previously possible. Physicists at the Univ. of Michigan have demonstrated "ponderomotive spectroscopy," an advanced form of a technique that was born in the 17th century when Isaac Newton first showed that white light sent through a prism breaks into a rainbow.

Promise and Limitations of Lab Automation Systems in R&D

February 13, 2015 3:56 pm | by Tim Studt, Editor-in-Chief | News | Comments

Lab automation systems are used in R&D laboratories for a wide range of operational applications and purposes. According to a recent reader survey performed by the editors of R&D Magazine in late-2014, the top three applications include to improve the accuracy of lab operations (selected by 61% of the readers), to improve lab productivity (58%) and to ensure the reliability of the lab operations (48%).

Six Tips to Use When Calibrating Your pH Meter

February 13, 2015 11:50 am | by Hanna Instruments | Articles | Comments

Reliable pH measurements are essential to a variety of processes and industries. From agriculture, to wastewater and plating, to food processing, measuring pH is a crucial step in determining the efficiency of a process or quality of a product. Vital steps in achieving accurate pH results include calibrating a pH meter and ensuring the electrode is working properly.

PNNL recognized for moving biofuel, chemical analysis innovations to market

February 2, 2015 7:24 am | by Eric Francavilla, PNNL | News | Comments

Developing renewable fuel from wet algae and enabling analysis of complex liquids are two of the latest innovations Pacific Northwest National Laboratory (PNNL) has successfully driven to the market with the help of commercial partners.

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Ultra-realistic radiation detection training without radioactive materials

January 14, 2015 10:49 am | by Kenneth Ma, LLNL | News | Comments

Training of first responders on the hazards of actual radiological and nuclear threats has been challenged by the difficulties of adequately representing those threats. Training against such threats would involve using hazardous, highly radioactive materials, experiencing actual radiation doses in training, or require the distribution of radioactive material over a large geographical area.

Scientists find unsuspected spectroscopy rules for rattling hydrogen

January 8, 2015 11:02 am | by New York Univ. | News | Comments

It has been taken for granted for over 50 years that the type of spectroscopy widely used to study hydrogen inside materials is not subject to any selection rules. In the joint theoretical and experimental study that appeared recently in Physical Review Letters, an international team of researchers showed that this near universally held view is incorrect for at least one important class of hydrogen-entrapping compounds.

Technology quickly traces source of tainted food

January 7, 2015 10:51 am | by Kenneth Ma, LLNL | News | Comments

Foodborne illnesses kill roughly 3,000 Americans each year and about one in six are sickened, according to the Centers for Disease Control and Prevention. Yet most contaminated foods are never traced back to their source. That’s because existing methods to track tainted food following its supply chain from table to farm are highly inefficient, jeopardizing the health of millions and costing the food industry billions.

Microfluidic Method for Primary Neuron Culture and Analysis

January 7, 2015 8:42 am | by Paul J. Hung, Shin-Yi Cindy Chen, Ivana Zubonja and Terry A. Gaige, EMD Millipore | Articles | Comments

Dissecting neuron function, while crucially important for understanding normal and pathological neurological processes, requires measuring the responses of live cells to external stimuli. Because of the inherent difficulties in performing perturbation analyses inside living organisms, there has been a longstanding drive towards developing methodologies for in vitro analysis of neurons.

Cells build “cupboards” to store metals

December 16, 2014 3:06 pm | by Anne M. Stark, Lawrence Livermore National Laboraotry | News | Comments

Lawrence Livermore National Laboratory researchers in conjunction with collaborators at Univ. of California, Los Angeles have found that some cells build intracellular compartments that allow the cell to store metals and maintain equilibrium. Nearly 40% of all proteins require metal ions such as zinc, copper, manganese or iron for activity.

Uncovering the Secrets Governing CVD of Graphene

December 15, 2014 11:24 am | by Mark H. Wall, Thermo Fisher Scientific, Madison, Wisc., Robert M. Jacobberger, Dept. of Material Science and Engineering, Univ. of Wisconsin-Madison and Elena Polyakova, Graphene Laboratories, Ronkonkoma, N.Y. | Thermo Fisher Scientific | Articles | Comments

One major challenge currently facing the graphene industry is difficulty in controlling the quality of graphene sheets when produced over large areas using industrial scale techniques. The key to solving this challenge lies in gaining a thorough understanding of the synthetic methods used to fabricate macro-sized single-layer graphene films.

A Tool for Today’s Complex Health Challenges

December 15, 2014 11:06 am | by Waters Corp. | Articles | Comments

Nearly half of all U.S. adults, nearly 117 million individuals, are living with one or more chronic health conditions. This has become the age of chronic disease, and achieving better outcomes depends on developing tools for research and clinical care that efficiently and accurately address the complex diseases we face today.

An Inside Look to Analytical Innovation

December 4, 2014 4:10 pm | by Lindsay Hock, Managing Editor | Award Winners

During the 2014 R&D 100 Awards event, R&D Magazine expanded the banquet to hold four technology panels during the day. The first panel focused on analytical instrumentation and the innovation behind four R&D 100-winning technologies and the complexity of bringing such instrumentation to the market.

NIR Drills Into the Energy Industry

December 4, 2014 2:16 pm | by Lindsay Hock, Managing Editor | Articles | Comments

Hydrocarbon exploration by definition is the search by geologists or geophysicists for hydrocarbon deposits beneath the Earth’s surface, such as oil (petroleum) and natural gas. In such exploration, the oil and gas industry drills holes into the Earth’s surface to extract the petroleum or natural gas. However, such exploration is expensive, not to mention a high-risk operation.

A better look at the chemistry of interfaces

December 2, 2014 4:41 pm | by Lynn Yarris, Lawrence Berkeley National Laboratory | News | Comments

Researchers have combined key features of two highly acclaimed x-ray spectroscopy techniques into a new technique that offers sub-nanometer resolution of every chemical element to be found at heterogeneous interfaces, such as those in batteries and fuel cells. This new technique is called SWAPPS for Standing Wave Ambient Pressure Photoelectron Spectroscopy.

Trace Analysis of Carbon Dioxide in High-Purity Hydrofluorocarbon

November 25, 2014 4:15 pm | by Zhuangzhi “Max” Wang, Clifford M. Taylor, Shimadzu Scientific Instruments, Columbia, Md. | Articles | Comments

Fluorocarbon, a generic term for organic compounds with carbon-fluorine (C-F) bonding, is a chemical material used as a refrigerant in refrigerators and freezers and air conditioners in cars, buses, other vehicles and buildings. It’s also used as a cleaning agent for electronic components and precision parts.

Evolution of NIR Spectroscopy: Past, Present and Future

November 14, 2014 4:04 pm | by Joe Siddall, TI DLP Embedded Products Program Manager | Articles | Comments

Near-infrared (NIR) spectrometers have been around for over 60 years, yet only a small fraction of the population is familiar with these dependable tools. It’s astounding that NIR spectroscopy does so much for so many people who have never heard the word “spectrometer.” NIR spectrometers help a diverse set of users make decisions in their daily jobs.

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