The Siemens Healthcare Diagnostics D-dimer assay for the company's Stratus CS Acute Care Diagnostic System has been cleared by the FDA to exclude pulmonary embolism in conjunction with a non-high clinical pretest probability assessment model in point-of-care.
A study involving researchers at Caltech points to the possibility of using neutralizing antibodies in the development of a vaccine for HIV. Their research describes a group of novel antibodies that were isolated from HIV-infected individuals using a new cloning approach.
A breakthrough in sensing at Rice University could make finding signs of Alzheimer's disease nearly as simple as switching on a light. The technique should help researchers design better medications to treat the devastating disease.
Researchers at the Georgia Institute of Technology have designed a multiple-compartment gel capsule that could be used to simultaneously deliver drugs of different types. The researchers used a simple one-pot method to prepare the hydrogel capsules, which measure less than one micron.
Researchers have identified a protein long known to regulate gene expression as a potent suppressor of breast cancer growth. Their study is the first to demonstrate how this protein, known as Runx3, accomplishes this feat.
By accounting for the floppy, fickle nature of RNA, researchers at the Univ. of Michigan and the Univ. of California, Irvine have developed a new way to search for drugs that target this important molecule.
Compounds that act as natural antifreeze are used for protecting drugs, food and tissues. One common type of cryoprotectant features osmolyte molecules. Researchers have found that larger osmolytes are better at protecting proteins than smaller ones. The results could have major implications for the pharmaceutical industry, which loses product to the freezing process.
Troubled proteins in need of rescue may someday have a champion in a common drug used to treat high blood pressure. Rice Univ. research suggests lacidipine, a calcium channel blocker also known by brand names Lacipil and Motens, could be a key to helping people who suffer from an incurable, neuropathic form of Gaucher disease.
Ever since HIV was revealed as the infectious agent behind the AIDS epidemic, scientists have been striving to develop a vaccine against the disease. However, the task has proven difficult, because HIV mutates so rapidly. In a new finding that may allow vaccine designers to sidestep part of that obstacle, researchers at the Ragon Institute of Massachusetts General Hospital, MIT, and Harvard Univ. have identified sections of an HIV protein where mutations would actually undermine the virus’ ability to survive and reproduce.
Stem cell technologies have been proposed for cell-based diagnostics and regenerative medicine therapies. However, being able to make stem cells efficiently develop into a desired cell type limits the clinical potential of these technologies. New research shows that systematically controlling the local and global environments during stem cell development helps to effectively direct the process of differentiation.
A potential life-saving treatment for severe E. coli food poisoning outbreaks—developed more than a decade ago—hasn't gone forward into clinical trials because of lack of commercial interest. Univ. of Adelaide researchers produced a "designer" probiotic bacterium which binds and neutralizes the toxin produced by E. coli , which causes life-threatening attack on the kidneys and blood vessels.
Teams from the U.S. and Germany have developed a spray drying technique to fabricate drug formulations smaller than 100 nm for pharmaceutical trials, improving the drugs' solubility, or bioavailability.
Radius Health, Inc. (Radius) and 3M Drug Delivery Systems (3M) announced an agreement to collaborate on the development of a transdermal delivery option of BA058, Radius’ novel, proprietary PTHrP (parathyroid hormone-related protein) analog, for the treatment of osteoporosis.
A new "organocatalyst" developed at Oregon State Univ. is now available for commercial use. Produced by an Albany, Ore., pharmaceutical company, it should make new drug development around the world less costly, more efficient, and more environmentally friendly.
Researchers at the Florida campus of The Scripps Research Institute have developed the first of a new class of highly selective compounds that effectively suppresses the severity of multiple sclerosis in animal models. The discovery also holds promise for other autoimmune disorders.
Shimadzu’s new MOC63u Moisture Balance features UniBloc sensor technology to help ensure reliable laboratory testing, including fast response time and stable corner-load performance during analyses.
People suffering from multiple sclerosis may benefit if patent-pending research conducted at Purdue Univ. shows that a decades-old drug approved by the FDA to treat hypertension also can delay the onset and reduce the severity of MS symptoms.
Edwards Vacuum has won a contract to supply Quorum Technologies with its EXT75DX turbomolecular vacuum pumps for cryogenic preparation chambers used in scanning electron microscopy applications. The oil-free pump allows Quorum to perform cold fracturing, controlled sublimation, and specimen coating for reliable microstructure analysis.
Chemotherapy drug resistance contributes to treatment failure in more than 90% of metastatic cancers. Overcoming this hurdle would improve cancer survival rates. Dean Ho, an associate professor of biomedical engineering and mechanical engineering at Northwestern Univ., believes a tiny carbon particle called a nanodiamond may offer an effective drug delivery solution for hard-to-treat cancers.
In a new study from MIT, researchers have identified a single mutation in the H1N1 genetic makeup that would allow it to be much more easily transmitted between people. The finding should give the World Health Organization, which tracks influenza evolution, something to watch out for.
A Stanford lawsuit that began as a patent infringement case against a drug company has evolved into a dispute over a federal law that promotes the commercialization of government-sponsored research and protects ownership rights of universities to inventions arising from government-sponsored research.
Ben-Gurion Univ. of the Negev (BGU) researchers have developed a unique technology that stabilizes an otherwise unstable form of calcium carbonate. This mineral form provides significantly higher biological absorption and retention rates than other sources presently used as dietary calcium supplements.
A team of Yale Univ. scientists has, for the first time, synthesized a chemical compound called lomaiviticin aglycon, leading to the development of a new class of molecules that appear to target and destroy cancer stem cells.
Many drugs can only be absorbed in very specific parts of the intestine. In a new paper, Brown Univ. scientists describe a new system that can safely hold a magnetic gelatin capsule in place anywhere in the gastrointestinal tract of a rat. In humans, the system could improve drug delivery and pharmacological research.
When an antibiotic is consumed, researchers have learned that up to 90% passes through a body without metabolizing. This means the drugs can leave the body almost intact through normal bodily functions. In the case of agricultural areas, excreted antibiotics can then enter stream and river environments through a variety of ways. Water filtered through wastewater treatment plants may also contain used antibiotics. Consequently, these discharges become a potential source of antiboitic resistance genes, according to an associate professor of engineering at Virginia Tech.