The superbugs have met their match. Conceived at Nanyang Technological University, it comes in the form of a coating which has a magnetic-like feature that attracts bacteria and kills them without the need for antibiotics.
A cross-disciplinary team of researchers at the University of Maryland has designed a molecular container that can hold drug molecules and increase their solubility, in one case up to nearly 3000 times. Their discovery opens the possibility of rehabilitating drug candidates that were insufficiently soluble.
University of Manchester scientists have discovered an Achilles heel within cells that bacteria are able to exploit to cause and spread infection. The researchers say their findings could lead to the development of new anti-infective drugs as alternatives to antibiotics whose overuse has led to resistance.
Yale University researchers show in detail how three genes within human embryonic stem cells regulate development, a finding that increases understanding of how to grow these cells for therapeutic purposes. This process is different in humans than in mice, highlighting the importance of research using human embryonic stem cells.
An international consortium has determined the structure of an important new drug target in complex with a synthetic molecule designed by University of Bath researchers, opening up new avenues for drug discovery.
Researchers at Brown University and Hasbro Children's Hospital have traced the molecular interactions that allow the protein survivin to escape the nucleus of a breast cancer cell and prolong the cell's life. The study may help in the development of better therapies and prognostics.
In search of ways to fight antibiotic-resistant bacteria, Australian scientists are analyzing synthetic antimicrobial skin secretions of Australian Green-Eyed and Growling Grass frogs. These two species were selected because peptides secreted from their skin form a defense to a broad spectrum of bacteria including Staphylococcus .
The California Institute for Quantitative Biosciences (QB3) has renewed and expanded a three-year agreement with Pfizer Inc. to collaborate on research projects at the University of California (UC) with the potential to transform world-class science into better medicine. Renewal spans 4 UC campuses.
Huntington's disease, the debilitating congenital neurological disorder that progressively robs patients of muscle coordination and cognitive ability, is a condition without effective treatment, a slow death sentence. But if researchers can build on new research, a special type of brain cell forged from stem cells could help restore the muscle coordination deficits that cause the uncontrollable spasms characteristic of the disease.
In preclinical studies, researchers at SRI International and Astraea Therapeutics have recently evaluated the role of a new drug receptor target that shows promise for the treatment of drug addiction. This potential new drug target belongs to a class of receptors called the nicotinic acetylcholine receptors.
Traditional drug manufacturing is a time-consuming process. Active pharmaceutical ingredients are synthesized in a chemical manufacturing plant and then shipped to another site, where they are converted into giant batches of pills. Including transport time between manufacturing plants, each batch can take weeks or months to produce. However, Massachusetts Institute of Technology and Novartis launched a research effort to transform those procedures.
A University of Michigan cell biologist and his colleagues have identified a potential drug that speeds up trash removal from the cell's recycling center, the lysosome. The finding suggests a new way to treat rare inherited metabolic disorders and common neurodegenerative diseases.
The humble aspirin may soon have a new role. Scientists from The City College of New York have developed a new aspirin compound that has great promise to be not only an extremely potent cancer fighter, but even safer than the classic medicine cabinet staple.
Researchers are reporting the first treatment to speed recovery from severe brain injuries caused by falls and car crashes: a cheap flu medicine whose side benefits were discovered by accident decades ago. Severely injured patients who were given amantadine got better faster than those who received a dummy medicine.
A chemically altered osteoporosis drug may be useful in fighting malaria, researchers report in a new study. Unlike similar compounds tested against many other parasitic protozoa, the drug readily crosses into the red blood cells of malaria-infected mice and kills the malaria parasite. The drug works at very low concentrations with no observed toxicity to the mouse.
Scientists at The University of Nottingham have discovered a new molecule that could offer the hope of new treatments for people allergic to the house dust mite. The molecule, DC-SIGN, can be found on the surface of the immune cells which play a key role in the recognition of a major allergen from house dust mites called Der p 1, a leading cause of asthma.
Cyanide poisoning is often fatal and typically affects victims of industrial accidents, terrorist attacks, or structural fires. Based on research conducted at the Center for Drug Design at the University of Minnesota, startup Vytacera Pharma Inc. will develop and market Sulfanegen, a treatment for cyanide poisoning.
University of Texas, Arlington engineers working with Army surgeons are developing a pliable, polymer mask embedded with electrical, mechanical, and biological components that can speed healing from disfiguring facial burns and help rebuild the faces of injured soldiers.
A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.
Modified probiotics, the beneficial bacteria touted for their role in digestive health, could one day decrease the risk of Listeria infection in people with susceptible immune systems, according to Purdue University research.
New research demonstrates that previous models used to examine cancer may not be complex enough to accurately mimic the true cancer environment. Using oral cancer cells in a 3D model of lab-made tissue that mimics the lining of the oral cavity, the researchers found that the tissue surrounding cancer cells can epigenetically mediate, or temporarily trigger, the expression or suppression of a cell adhesion protein associated with the progression of cancer.
Ariel Pharmaceuticals, a private, development-stage pharmaceutical company focused on the development and commercialization of products for indications in acute central nervous system diseases and trauma, announced it has signed a cooperative research and development agreement (CRADA) with the United States Army Medical Research and Material Command.
Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding. The research identified new genes and pathways that prevent protein misfolding and toxic aggregation, keeping cells healthy, and also identified small molecules with therapeutic potential that restore health to damaged cells, providing new targets for drug development.
Testing the effectiveness of new pharmaceuticals may get faster thanks to a new technique incorporating quantum dots developed at the University of Central Florida (UCF). Some drug testing can take a decade or more, but a UCF team has created an electronic quantum dots (Qdots) probe that "lights up" when a drug it is delivering attaches to cancer cells.
Scientists at Purdue University and eight other institutions have developed new resources poised to unlock another door in the hidden garden of medicinally important compounds found in plants.