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Biogen seeks approval of hemophilia A treatment

March 12, 2013 11:24 am | by The Associated Press | News | Comments

Biogen Idec has filed for federal marketing approval of a longer-lasting treatment for hemophilia A. Biogen says the drug rFVIIIFc can be injected once or twice a week, while other treatments for hemophilia A need to be injected three or four times a week. The drug could be the first major advance in the treatment of hemophilia in more than 20 years.

India rejects Bayer plea against cheap cancer drug

March 5, 2013 10:15 am | by Nirmala George, Associated Press | News | Comments

India's patent appeals office has rejected Bayer AG's plea to stop the production of a cheaper generic version of a patented cancer drug in a ruling that health groups say is an important precedent for getting inexpensive lifesaving medicines to the poor. Bayer sells a one month supply of the drug for about $5,600. Natco's version would cost Indian patients $175 a month, less than 1/30th as much.

Polymer scientists develop double switchable membrane

February 27, 2013 10:46 pm | News | Comments

Pharmaceutical residues in water can pose a danger to humans. Filtration is often very difficult as these trace substances, which are soluble in water, are so minute. Newly-developed double switchable membranes could make it possible to filter these molecules, as well as other  biomolecules such as proteins and nucleic acids. The new membranes can reduce or enlarge pore size through changes in temperature and pH value.

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NIH chief: Cuts put vital medical research at risk

February 14, 2013 2:24 pm | by LAURAN NEERGAARD - AP Medical Writer - Associated Press | News | Comments

Better cancer drugs that zero in on a tumor with fewer side effects. A universal flu vaccine that could fight every strain of influenza without needing a yearly shot. Research into potentially life-saving products like these will be delayed and newer discoveries shelved if Congress can't avert impending budget cuts that the director of the National Institutes of Health warns will have far-reaching effects.

New method uncovers side effects before a drug hits the market

February 13, 2013 3:19 pm | News | Comments

Side effects are a major reason that drugs are taken off the market and a major reason why patients stop taking their medications, but scientists are now reporting the development of a new way to predict those adverse reactions ahead of time. The computer-based approach could save patients from severe side effects and save drug companies time and money.

Amgen, UCB halt testing of fracture-healing drug

February 11, 2013 4:34 pm | by LINDA A. JOHNSON - AP Business Writer - Associated Press | News | Comments

Biotech giant Amgen Inc. and Belgian drugmaker UCB SA have scrapped plans for late-stage testing of an experimental treatment for accelerated healing of fractures, but will continue testing their drug for a much bigger and potentially lucrative market, treating osteoporosis in postmenopausal women.

Lilly stops rheumatoid arthritis treatment study

February 7, 2013 10:33 am | by The Associated Press | News | Comments

Drug developer Eli Lilly and Co. is stopping clinical testing of an experimental rheumatoid arthritis treatment because it wasn't working. The Indianapolis company said Thursday it will continue studying the potential drug, tabalumab, as a possible treatment for a form of the autoimmune disorder lupus and the bone marrow cancer multiple myeloma.

FDA accepts application for new Sanofi MS drug

January 28, 2013 11:17 am | by The Associated Press | News | Comments

French drugmaker Sanofi said Monday that the Food and Drug Administration will review its experimental multiple sclerosis treatment Lemtrada. Genzyme, Sanofi's U.S. biotech business, said the FDA will conduct a standard 10-month review and will make a decision on the drug in late 2013.

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Emerging vector-borne diseases create public health challenge

November 30, 2012 10:35 am | News | Comments

A series of papers published recently in the journal The Lancet are calling attention to the rapid spread of vector-borne, zoonotic diseases such as West Nile virus, dengue fever, and Lyme disease. These diseases, spread to humans by animals like mosquitos and ticks, are advancing as a result of urbanization, land use, and more intensive agricultural practices.

Additive restores antibiotic effectiveness against MRSA

October 22, 2012 4:50 pm | News | Comments

Researchers from North Carolina State University have increased the potency of a compound that reactivates antibiotics against methicillin-resistant Staphylococcus aureus (MRSA). Their improved compound removes the bacteria's antibiotic resistance and allows the antibiotic to once again become effective at normal dosage levels.

Nanoscale drug discovery approach relies on in silico, in vivo, in vitro

October 10, 2012 10:58 am | News | Comments

Using in silico computational tools to complement the results of in vivo and in vitro experiments, researchers at Pacific Northwest National Laboratory have revealed an atomic-level understanding of the mechanism by which nanoparticles inhibit the growth and metastasis of pancreatic tumors. The findings are promising for the development of particle-based therapies.

New study says nanoparticles don't penetrate the skin

October 1, 2012 3:46 am | News | Comments

Research by scientists at the University of Bath is challenging claims that nanoparticles in medicated and cosmetic creams are able to transport and deliver active ingredients deep inside the skin. The study discovered that even the tiniest of nanoparticles did not penetrate the skin's surface.

Scientists uncover virus with potential to stop pimples

September 26, 2012 6:18 am | News | Comments

Watch out, acne. Doctors soon may have a new weapon against zits: A harmless virus living on our skin that naturally seeks out and kills the bacteria that cause pimples. In the new findings, scientists looked at two little microbes that share a big name: Propionibacterium acnes , a bacterium thriving in our pores that can trigger acne, and P. acnes phages, a family of viruses that live on human skin.

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Insight into snake venom evolution could aid drug discovery

September 19, 2012 3:50 am | News | Comments

U.K.-led scientists have made a discovery about snake venom that could lead to the development of new drugs to treat a range of life-threatening conditions. The researchers have discovered that the toxins that make snake and lizard venom deadly can evolve back into completely harmless molecules, raising the possibility that they could be developed into drugs.

Accelrys to streamline lab-to-market with process and compliance suite

September 18, 2012 4:35 am | News | Comments

Designed to improve the way businesses manage the scientific innovation lifecycle, the new Accelrys Process Management and Compliance Suite unifies Accelrys Inc.’s lifecycle management software offerings, covering the ground between product development and process execution. It is geared to help companies bring products to market faster and at a lower cost, while meeting critical quality and regulatory compliance objectives.

EMD Millipore, iPS Academia Japan sign licensing agreement

September 17, 2012 10:06 am | News | Comments

EMD Millipore and iPS Academia Japan Inc. (AJ) announced a global licensing agreement for AJ's induced pluripotent stem (iPS) cell patent portfolio. The non-exclusive agreement provides EMD Millipore the opportunity to continue to develop and ultimately commercialize iPS cells for research applications.

Real-world levitation to inspire better pharmaceuticals

September 13, 2012 5:15 am | News | Comments

It's not a magic trick and it's not sleight of hand—scientists really are using levitation to improve the drug development process, eventually yielding more effective pharmaceuticals with fewer side effects. Scientists at Argonne National Laboratory have discovered a way to use sound waves to levitate individual droplets of solutions containing different pharmaceuticals.

U.S. research and development most prevalent in small number of regions

September 13, 2012 4:29 am | News | Comments

According to data from a 2008 Business R&D and Innovation Survey by the National Science Foundation, businesses perform the lion's share of their R&D activity in just a small number of geographic areas, particularly the San Jose-San Francisco-Oakland area and the New York-Newark-Bridgeport area.

Clinical trials get efficiency boost from virtual reality

August 31, 2012 6:45 am | News | Comments

Time-consuming, expensive, and often intrusive, clinical trials are nevertheless a necessity. Researchers at the University of Tennessee Space Institute in Tullahoma have developed an invention that makes clinical trials more efficient. Called "digital Eye Bank," the computer software eye modeling program can take data from eyes of patients' and build it into models from the commercial optics program to be used for researchers' virtual clinical trials.

Scientist creates new cancer drug that is 10 times more potent

August 30, 2012 12:49 pm | News | Comments

In a new study, University of Missouri medicinal chemists have taken an existing drug that is being developed for use in fighting certain types of cancer and added a special cluster of three elements: boron, carbon, and hydrogen. This structure, called a carborane, has multiplied the binding force of the drug. Clinical could start within two years.

Nanoparticles reboot blood flow in brain

August 24, 2012 4:05 am | News | Comments

A nanoparticle developed at Rice University and tested in collaboration with Baylor College of Medicine may bring great benefits to the emergency treatment of brain-injury victims, even those with mild injuries. Combined polyethylene glycol-hydrophilic carbon clusters (PEG-HCC), already being tested to enhance cancer treatment, are also adept antioxidants. In animal studies, injections of PEG-HCC during initial treatment after an injury helped restore balance to the brain's vascular system.

Using years of cell evolution in the fight against cancer

August 9, 2012 8:47 am | News | Comments

As the medical community continues to make positive strides in personalized cancer therapy, scientists know some dead ends are unavoidable. Drugs that target specific genes in cancerous cells are effective, but not all proteins are targetable. In fact, it has been estimated that as few as 10% to 15% of human proteins are potentially targetable by drugs. For this reason, Georgia Institute of Technology researchers are focusing on ways to fight cancer by attacking defective genes before they are able to make proteins.

Scientists find way to make disease-causing proteins vulnerable to drugs

July 27, 2012 5:15 am | News | Comments

One of the most daunting challenges facing pharmaceutical scientists today are "undruggable proteins"—the approximately 80% of proteins involved in human disease that do not interact with current drugs. Yale University researchers have identified a novel way to design drugs for these previously inaccessible proteins.

iBio Inc., GE Healthcare form global alliance

July 26, 2012 8:49 am | News | Comments

iBio Inc. and GE Healthcare announced a new global alliance to commercialize plant-based technologies for the manufacture of biopharmaceuticals and vaccines. The alliance builds on the existing development and marketing agreement between the two companies announced in 2010.

New proteins inhibit HIV infection in cell cultures

July 24, 2012 4:00 am | News | Comments

Yale University Cancer Center scientists have developed a new class of proteins that inhibit HIV infection in cell cultures and may open the way to new strategies for treating and preventing infection by the virus that causes AIDS.

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