Over the past 20 years, the number of laboratory tests available to primary care physicians has doubled, to more than 3,500 tests, and physicians are challenged by the quantity of tests available. A recent survey conducted by the U.S. Centers for Disease Control and Prevention suggests they often face uncertainty in ordering and interpreting clinical laboratory tests, and would welcome better electronic clinical decision support tools.
Beckman Coulter Life Sciences has announced an...
For people whose hands shake uncontrollably due to...
For more than two years, researchers have been investigating melanopsin, a retina pigment capable of sensing light changes in the environment, informing the nervous system and synchronizing it with the day/night rhythm. They have found that this pigment is potentially more sensitive to light than its more famous counterpart rhodopsin, the pigment that allows night vision.
In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die.
The Salk Institute for Biological Studies will join Stanford Univ. in leading a new Center of Excellence in Stem Cell Genomics, created through a $40 million award by California's stem cell agency. The center will bring together experts and investigators from seven major California institutions to focus on bridging the fields of genomics with cutting-edge stem cell research and ultimately find new therapies.
In a Centers for Disease Control and Prevention (CDC) building on the outskirts of Atlanta, large metal vats are filled with a frozen array of specimens such as blood and DNA, many of them irreplaceable. Battelle has been awarded a five-year, $12.6 million contract to help manage this important biological repository, which contains 12 million biological samples.
Drugmaker Merck & Co. is joining two dozen other pharmaceutical companies and contract laboratories in committing to not use chimpanzees for research. The growing trend could mean roughly 1,000 chimps in the U.S. used for research or warehoused for many years in laboratory cages could be "retired" to sanctuaries by around 2020.
According to Anupam Agrawal, a professor of business administration at the Univ. of Illinois, Urbana-Champaign, firms can manage their sourcing better by developing relationships not only with their suppliers but also with their suppliers’ suppliers. The lack of communication or collaboration between the big players at either end of the supply chain spectrum can prevent gains in efficiencies.
Developed by a team of researchers in Massachusetts and California, “nanotraps” are nanoparticles that act as viral traps using specific molecules found naturally within the human body. Initial testing on the treatments, which each use tiny, non-toxic particles that can be injected, inhaled, or eaten, has shown them to be effective and safe against a multitude of strains of disease.
Agilent Technologies Inc. has introduced two new assays for the 2200 TapeStation system: the RNA ScreenTape and the D1000 ScreenTape assays. Both assays are essential for the quality control of samples in next-generation sequencing (NGS) workflow. They replace Agilent’s R6K and D1K ScreenTape assays.
At the 2013 American Society for Cell Biology Annual Meeting, Bruker introduced the Opterra Multipoint Scanning Confocal Microscope, which integrates confocal microscopy with photoactivation capabilities for applications in biology.
Researchers in China, working on the optimization of a third-generation sequencing technique based on nanopores, have found that long-chain DNA with low salt concentration is more conducive to the nanopore sequencing process. This finding may improve the efficiency of sequencing, and further low the cost of gene sequencing.
Bruker Corp. has announced that it has been granted U.S. FDA clearance under Section 510(k) to market its MALDI Biotyper CA System in the United States for the identification of Gram negative bacterial colonies cultured from human specimens. The clearance marks progress in Bruker’s efforts to develop MALDI-TOF mass spectrometry into the most advanced platform for clinical microbiology identification.
The European Commission has approved the pending acquisition of Life Technologies Corp. by Thermo Fisher Scientific, which has committed to divest its cell culture (sera and media), gene modulation and magnetic beads businesses to expedite the approval. Combined, these businesses had 2012 revenue of approximately $225 million.
The Food and Drug Administration has ordered Google-backed genetic test maker 23andMe to halt sales of its personalized DNA test kits. In a warning letter posted online Monday, FDA regulators say that the Silicon Valley company has not shown that its tests are safe or effective despite "more than 14 face-to-face and teleconference meetings" and "hundreds of email exchanges."
OnTarget Laboratories LLC has teamed with partners in academia to test a novel optical imaging technology developed at Purdue Univ. that could help surgeons see cancer tissue during surgery. The technology is based on the over-expression of specific receptors on solid cancerous tumors and enables illumination of the tumor tissue during surgery.
Researchers have developed a system that concentrates foodborne salmonella and other pathogens faster than conventional methods by using hollow thread-like fibers that filter out the cells. The machine, called a continuous cell concentration device, could make it possible to routinely analyze food or water samples to screen for pathogens within a single work shift at food processing plants.
There is certainly no shortage of lab-on-a-chip devices, but in most cases manufacturers have not yet found a cost-effective way to mass produce them. Scientists are now developing a platform for series production of these pocket laboratories. The first major step is moving away from the usual injection molding or wet chemical processing techniques in favor of roll-to-roll processing.
Accelrys Inc. has announced the release of Accelrys Insight and Accelrys Insight for Excel, completing the roll-out of Accelrys’ next-generation cheminformatics suite and providing an interactive, collaborative environment for rapid and effective decision-making in drug discovery.
With the rise of the iPhone, Android and other mobile devices has come a flood of applications designed to help people stay healthy. Food and Drug Administration officials say they will now begin regulating applications and gadgets that work with smartphones to take medical readings and help users monitor their health.
Cancer cells metastasize in several stages—first by invading surrounding tissue, then by infiltrating and spreading via the circulatory system. Some circulating cells work their way out of the vascular network, eventually forming a secondary tumor. Now researchers have developed a microfluidic device that mimics the flow of cancer cells through a system of blood vessels. High-resolution time-lapse imaging captures the moment of metastasis.
According to a recent study published by the National Science Foundation (NSF), businesses spent more on research and development (R&D) in 2011 than they did in 2010. The figures revealed that during 2011, companies in manufacturing industries performed $201 billion, or 68%, of domestic R&D.
A team of researchers at NIST and Applied Research Associates, Inc. has demonstrated an improved microfluidic technique for recovering DNA from real-world, complex mixtures such as dirt. According to the researchers their technique delivers DNA from these crude samples with much less effort and in less time than conventional techniques and yields DNA concentrations optimal for human identification procedures.
MicroRNAs are abundant, small regulatory RNA molecules with diverse cellular functions. But their use as reliable blood-based biomarkers has been undermined by factors such as high interday variability. A new study, however, now shows that droplet digital polymerase chain reaction (ddPCR) technology can be used to precisely and reproducibly quantify microRNA in plasma and serum across different days.
The Department of Systems Biology at the Technical University of Denmark (DTU) have formed a collaboration with Thermo Fisher Scientific to pursue breakthroughs in the understanding of how cellular protein networks drive important diseases. Under the collaboration, Thermo Fisher will provide early access to new technology and designs, and DTU proteomics scientists will provide feedback and collaborate on new applications.
Getting biomolecules past the body’s numerous defenses requires innovations such as drug-delivering nanoparticles. Polylactic acid (PLA) is a potential candidate because it is non-toxic, biodegradable, and spontaneously assembles into tiny structures under the right conditions. Researchers in Singapore have developed a robust method to synthesize PLA nanoparticles using copolymer technology and a rigid “nanocage” made from silicon.
Stem cell technology has long offered the hope of regenerating tissue to repair broken or damaged neural tissue. Findings from a team of Univ. of California, Davis investigators have brought this dream a step closer by developing a method to generate functioning brain cells that produce myelin, the fatty, insulating sheath essential to normal neural conduction.
- Page 1