Researchers at Columbia Univ. have made a significant step toward visualizing complex protein metabolism in living systems with high resolution and minimum disturbance, a longstanding goal in the scientific community. In a recent study, the research team has reported a light microscopy method to image where the new proteins are produced and where the old proteins are degraded inside living tissues and animals.
A new process that can sprout microscopic spikes on nearly any type of particle may lead to more environmentally friendly paints and a variety of other innovations. Made by a team of Univ. of Michigan engineers, the "hedgehog particles" are named for their bushy appearance under the microscope.
Understanding this electronic effect in organic molecules is crucial for their use in optoelectronic applications. In their article published in Nature Physics, the research team demonstrates measurements on the organic molecule cobalt phthalocyanine (CoPC) that can be explained only by taking into consideration how electrons in the molecule interact with each other.
A new semiconductor laser developed at Yale Univ. has the potential to significantly improve the imaging quality of the next generation of high-tech microscopes, laser projectors, photo lithography, holography and biomedical imaging. Based on a chaotic cavity laser, the technology combines the brightness of traditional lasers with the lower image corruption of light-emitting diodes.
Beginning with the invention of the first microscope in the late 1500s, scientists have been trying to peer into preserved cells and tissues with ever-greater magnification. The latest generation of so-called “super-resolution” microscopes can see inside cells with resolution better than 250 nm.
Ebola virus, Alzheimer's amyloid fibrils, tissue collagen scaffolds and cellular cytoskeleton are all filamentous structures that spontaneously assemble from individual proteins. Many protein filaments are well studied and are already finding use in regenerative medicine, molecular electronics and diagnostics. However, the very process of their assembly, protein fibrillogenesis, remains largely unrevealed.
In the race to design the world's first universal quantum computer, a special kind of diamond defect called a nitrogen vacancy (NV) center is playing a big role. NV centers consist of a nitrogen atom and a vacant site that together replace two adjacent carbon atoms in diamond crystal. The defects can record or store quantum information and transmit it in the form of light.
Neutrophils, a type of white blood cell, are the immune system’s all-terrain vehicles. The cells are recruited to fight infections or injury in any tissue or organ in the body despite differences in the cellular and biochemical composition. Researchers collaborated to devise a new technique for understanding how neutrophils move in these confined spaces.
Spotting molecule-sized features may become both easier and more accurate with a sensor developed at NIST. With their new design, NIST scientists may have found a way to sidestep some of the problems in calibrating atomic force microscopes (AFMs). The AFM is one of the main scientific workhorses of the nano age.
Univ. of California, Los Angeles researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes. The invention could lead to less expensive and more portable technology for performing common examinations of tissue, blood and other biomedical specimens.
Scientists have used advanced microscopy to carve out nanoscale designs on the surface of a new class of ionic polymer materials for the first time. The study provides new evidence that atomic force microscopy, or AFM, could be used to precisely fabricate materials needed for increasingly smaller devices.
Lawrence Livermore National Laboratory researchers in conjunction with collaborators at Univ. of California, Los Angeles have found that some cells build intracellular compartments that allow the cell to store metals and maintain equilibrium. Nearly 40% of all proteins require metal ions such as zinc, copper, manganese or iron for activity.
A walking molecule, so small that it cannot be observed directly with a microscope, has been recorded taking its first nanometer-sized steps. It's the first time that anyone has shown in real time that such a tiny object – termed a "small molecule walker" – has taken a series of steps.
Researchers at Rice University have created flexible, patterned sheets of multilayer graphene from a cheap polymer by burning it with a computer-controlled laser. The process works in air at room temperature and eliminates the need for hot furnaces and controlled environments, and it makes graphene that may be suitable for electronics or energy storage.
A team of researchers from Argonne National Laboratory and Ohio Univ. have devised a powerful technique that simultaneously resolves the chemical characterization and topography of nanoscale materials down to the height of a single atom. The technique combines synchrotron x-rays (SX) and scanning tunneling microscopy (STM). In experiments, the researchers used SX as a probe and a nanofabricated smart tip of a STM as a detector.
Single-walled carbon nanotubes are loaded with desirable properties. In particular, the ability to conduct electricity at high rates of speed makes them attractive for use as nanoscale transistors. But this and other properties are largely dependent on their structure, and their structure is determined when the nanotube is just beginning to form.
Expensive tests for measuring everything from sperm motility to cancer diagnosis have just been made cheaper by a graduate student from Brunel Univ. London who hacked his own microscope. Adam Lynch, from the university’s College of Health and Life Sciences, created his own inverted microscope by adapting a cheap instrument he bought online to save himself time and money.
For the first time, scientists have vividly mapped the shapes and textures of high-order modes of Brownian motions—in this case, the collective macroscopic movement of molecules in microdisk resonators—researchers at Case Western Reserve Univ. report. To do this, they used a record-setting scanning optical interferometry technique.
Since the 1850s scientists have known that crystalline materials are organized into fourteen different basic lattice structures. However, a team of researchers from Vanderbilt Univ. and Oak Ridge National Laboratory now reports that it has discovered an entirely new form of crystalline order that simultaneously exhibits both crystal and polycrystalline properties, which they describe as "interlaced crystals."
Nikon Instruments, Inc. has revealed the winners of the 40th annual Nikon Small World Photomicrography Competition, awarding first prize to veteran competitor Rogelio Moreno of Panama for capturing a rarely seen image of a rotifer’s open mouth interior and heart-shaped corona.
Researchers in Japan have directly observed and recorded electron flow at 80,000 m/sec in a semiconductor. They did so by combining a new laser pulse light source and a photoemission electron microscope to develop an ultra high-speed microscope that enabled visualization of electrons on a 20 nm and 200 femtosec scale.
Researchers with CiQUS in Spain have developed a new method to overcome limitations of surface enhanced Raman spectroscopy (SERS), an ultra-sensitive analytical technique able to detect chemicals in very low concentration. The research results show how to cut production costs of substrates and also tackle the lack of reproducibility usually associated to this technique.
Univ. of Oregon chemists have devised a way to see the internal structures of electronic waves trapped in carbon nanotubes by external electrostatic charges. Their atomic scale observations provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices.
Scientists at Oak Ridge National Laboratory have discovered exceptional properties in a garnet material that could enable development of higher-energy battery designs. The team used electron microscopy to take an atomic-level look at a cubic garnet material called LLZO. The researchers found the material to be highly stable in a range of aqueous environments, making the compound a promising component in new battery configurations.
A leader in the field of minimally invasive surgery device development operates state-of-the-art R&D and manufacturing facilities—facilities that depend on today’s most advanced quality assurance/quality testing procedures. To ensure all equipment leaving its production facilities meets the highest performance and reliability standards, the company relies on a QA/QC system made possible by industrial microscope and analyzer solutions.