The 2014 chemistry Nobel Prize recognized important microscopy research that enabled greatly improved spatial resolution. This innovation, resulting in nanometer resolution, was made possible by making the emitter of the illumination quite small and by moving it quite close to the object being imaged. One problem with this approach is in such proximity, the emitter and object can interact with each other, blurring the resulting image.
To fully understand how nanomaterials behave, one must also understand the atomic-scale deformation mechanisms that determine their structure and, therefore, their strength and function. Researchers have engineered a new way to observe and study these mechanisms and, in doing so, have revealed an interesting phenomenon in a well-known material, tungsten.
Scientists at Oak Ridge National Laboratory (ORNL) have captured the first real-time nanoscale images of lithium dendrite structures known to degrade lithium-ion batteries. The ORNL team’s electron microscopy could help researchers address long-standing issues related to battery performance and safety.
Scientists have captured the first detailed microscopy images of ultra-small bacteria that are believed to be about as small as life can get. The existence of ultra-small bacteria has been debated for two decades, but there hasn’t been a comprehensive electron microscopy and DNA-based description of the microbes until now.
Delivering the capability to image nanostructures and chemical reactions down to nanometer resolution requires a new class of x-ray microscope that can perform precision microscopy experiments using ultra-bright x-rays from the National Synchrotron Light Source II (NSLS-II) at Brookhaven National Laboratory.
Electrical impulses play an important role in cells of the human body. For example, neurons use these impulses to transmit information along their branches and the body also uses them to control the contraction of muscles. The impulses are generated when special channel proteins open in the outer envelope of the cells, allowing charged molecules (ions) to enter or exit the cell. These proteins are referred to as ion channels.
Traditional fluorescence microscopy has suffered from the resolution limits imposed by diffraction and the finite wavelength of light. Classical resolution is typically limited to about 200 nm in xy. Due to the nanoscale architecture of many biological structures, researchers developed super-resolution techniques, starting in the 1990s, to overcome this classical resolution limit in light microscopy.
Researchers from North Carolina State Univ. are using a technique they developed to observe minute distortions in the atomic structure of complex materials, shedding light on what causes these distortions and opening the door to studies on how such atomic-scale variations can influence a material's properties.
Anyone who has ever toasted the top of their legs with their laptop or broiled their ear on a cell phone knows that microelectronic devices can give off a lot of heat. These devices contain a multitude of transistors, and although each one produces very little heat individually, their combined thermal output is significant and can damage the device.
Researchers at Columbia Univ. have made a significant step toward visualizing complex protein metabolism in living systems with high resolution and minimum disturbance, a longstanding goal in the scientific community. In a recent study, the research team has reported a light microscopy method to image where the new proteins are produced and where the old proteins are degraded inside living tissues and animals.
A new process that can sprout microscopic spikes on nearly any type of particle may lead to more environmentally friendly paints and a variety of other innovations. Made by a team of Univ. of Michigan engineers, the "hedgehog particles" are named for their bushy appearance under the microscope.
Understanding this electronic effect in organic molecules is crucial for their use in optoelectronic applications. In their article published in Nature Physics, the research team demonstrates measurements on the organic molecule cobalt phthalocyanine (CoPC) that can be explained only by taking into consideration how electrons in the molecule interact with each other.
A new semiconductor laser developed at Yale Univ. has the potential to significantly improve the imaging quality of the next generation of high-tech microscopes, laser projectors, photo lithography, holography and biomedical imaging. Based on a chaotic cavity laser, the technology combines the brightness of traditional lasers with the lower image corruption of light-emitting diodes.
Beginning with the invention of the first microscope in the late 1500s, scientists have been trying to peer into preserved cells and tissues with ever-greater magnification. The latest generation of so-called “super-resolution” microscopes can see inside cells with resolution better than 250 nm.
Ebola virus, Alzheimer's amyloid fibrils, tissue collagen scaffolds and cellular cytoskeleton are all filamentous structures that spontaneously assemble from individual proteins. Many protein filaments are well studied and are already finding use in regenerative medicine, molecular electronics and diagnostics. However, the very process of their assembly, protein fibrillogenesis, remains largely unrevealed.
In the race to design the world's first universal quantum computer, a special kind of diamond defect called a nitrogen vacancy (NV) center is playing a big role. NV centers consist of a nitrogen atom and a vacant site that together replace two adjacent carbon atoms in diamond crystal. The defects can record or store quantum information and transmit it in the form of light.
Neutrophils, a type of white blood cell, are the immune system’s all-terrain vehicles. The cells are recruited to fight infections or injury in any tissue or organ in the body despite differences in the cellular and biochemical composition. Researchers collaborated to devise a new technique for understanding how neutrophils move in these confined spaces.
Spotting molecule-sized features may become both easier and more accurate with a sensor developed at NIST. With their new design, NIST scientists may have found a way to sidestep some of the problems in calibrating atomic force microscopes (AFMs). The AFM is one of the main scientific workhorses of the nano age.
Univ. of California, Los Angeles researchers have developed a lens-free microscope that can be used to detect the presence of cancer or other cell-level abnormalities with the same accuracy as larger and more expensive optical microscopes. The invention could lead to less expensive and more portable technology for performing common examinations of tissue, blood and other biomedical specimens.
Scientists have used advanced microscopy to carve out nanoscale designs on the surface of a new class of ionic polymer materials for the first time. The study provides new evidence that atomic force microscopy, or AFM, could be used to precisely fabricate materials needed for increasingly smaller devices.
Lawrence Livermore National Laboratory researchers in conjunction with collaborators at Univ. of California, Los Angeles have found that some cells build intracellular compartments that allow the cell to store metals and maintain equilibrium. Nearly 40% of all proteins require metal ions such as zinc, copper, manganese or iron for activity.
A walking molecule, so small that it cannot be observed directly with a microscope, has been recorded taking its first nanometer-sized steps. It's the first time that anyone has shown in real time that such a tiny object – termed a "small molecule walker" – has taken a series of steps.
Researchers at Rice University have created flexible, patterned sheets of multilayer graphene from a cheap polymer by burning it with a computer-controlled laser. The process works in air at room temperature and eliminates the need for hot furnaces and controlled environments, and it makes graphene that may be suitable for electronics or energy storage.
A team of researchers from Argonne National Laboratory and Ohio Univ. have devised a powerful technique that simultaneously resolves the chemical characterization and topography of nanoscale materials down to the height of a single atom. The technique combines synchrotron x-rays (SX) and scanning tunneling microscopy (STM). In experiments, the researchers used SX as a probe and a nanofabricated smart tip of a STM as a detector.
Single-walled carbon nanotubes are loaded with desirable properties. In particular, the ability to conduct electricity at high rates of speed makes them attractive for use as nanoscale transistors. But this and other properties are largely dependent on their structure, and their structure is determined when the nanotube is just beginning to form.