Big data can mean big headaches for scientists. A new library of software tools from Howard Hughes Medical Institute’s Janelia Research Campus speeds analysis of data sets so large and complex they would take days or weeks to analyze on a single workstation, even if a single workstation could do it at all. The new tool, Thunder, should help interpret data that holds new insights into how the brain works.
A novel combination of microscopy and data processing has given researchers at Oak Ridge...
Bamboo construction has traditionally been rather straightforward: Entire stalks are used to...
Graphene, a material that consists of a lattice of carbon atoms, one atom thick, is widely touted as being the most electrically conductive material ever studied. However, not all graphene is the same. With so few atoms comprising the entirety of the material, the arrangement of each one has an impact on its overall function.
Janelia Research Campus experts have built a new computational method that can essentially automate much of the time-consuming process of reconstructing an animal's developmental building plan cell by cell. Using image data obtaining using a sophisticated form of light sheet microscopy, the tool can track the movement of cells in an animal’s body in 3-D.
In the U.K., researchers have revealed the structure of one of the most important and complicated proteins in cell division, the anaphase-promoting complex. Electron microscopy and software has produced images of the gigantic protein in unprecedented detail and could transform scientists' understanding of exactly how cells copy their chromosomes and divide. It could also reveal binding sites for future cancer drugs.
Barnacle glue, or cement, sticks to any surface, under any conditions. And it’s still far better than anything we have been able to develop synthetically. Now, over 150 years since it was first described by Charles Darwin, scientists are finally uncovering the secrets behind the super strength of barnacle glue.
Using a newly developed, ultrafast femtosecond infrared light source, chemists at the University of Chicago have been able to directly visualize the coordinated vibrations between hydrogen-bonded molecules. This marks the first time this sort of chemical interaction, which is found in nature everywhere at the molecular level, has been directly visualized.
Geckos and spiders seem to be able to sit still forever upside down. But sooner or later the grip is lost, no matter how little force is acting on it. Engineers, using scanning electron microscopy, have recently demonstrated why this is so by showing how heat, and the subsequent movement of molecules at the nanoscale, eventually force loss of adhesion.
Located deep in the human gut, the small intestine is not easy to examine: X-rays, MRIs and ultrasound images each suffer limitations. Univ. at Buffalo researchers are developing a new imaging technique involving nanoparticles suspended in liquid to form “nanojuice” that patients would drink. Upon reaching the small intestine, doctors would strike the nanoparticles with laser light, providing a non-invasive, real-time view of the organ.
Researchers have already used molecular rotors as viscosity sensor probes in live cells, but a recent study in Singapore is the first to report on the use of fluorescent molecular rotors to study critical protein interactions.
Whenever there is a major spill of oil into water, the two tend to mix into a suspension of tiny droplets, called an emulsion, that is extremely hard to separate and can cause severe damage to ecosystems. A new membrane developed by Massachusetts Institute of Technology researchers can separate even these highly mixed fine oil-spill residues.
Many enzymes work only with a co-trainer, of sorts. Scientists in Germany have shown what this kind of cooperation looks like in detail using a novel methodology applied to the heat shock protein Hsp90, which controls the proper folding of other proteins. Together with a second molecule, the co-chaperone P23, it splits the energy source ATP to yield the energy it needs to do its work.
Physicists in Europe have solved a mystery that has puzzled scientists for half a century. it has long been known that the distance between the graphene oxide layers depends on the humidity, not the actual amount of water added. But now, with the help of powerful microscopes, it can be seen how distance between graphite oxide layers gradually increases when water molecules are added, and why this phenomenon occurs.
An international team of physicists including researchers from the U.S. Naval Research Laboratory has used a scanning tunneling microscope to create quantum dots with identical, deterministic sizes. The perfect reproducibility of these dots opens the door to quantum dot architectures completely free of uncontrolled variations, an important goal for technologies from nanophotonics to quantum information processing.
At the nanoscale, where objects are measured in billionths of meters and events transpire in trillionths of seconds, things do not always behave as our experiences with the macro world might lead us to expect. Water, for example, seems to flow much faster within carbon nanotubes than classical physics says should be possible. Now imagine trying to capture movies of these almost imperceptibly small nanoscale movements.
Using high speed video, transmission electron microscopy, spectrometry, energy dispersive x-ray spectroscopy, and computer modeling, a Univ. of California, Berkeley graduate student has unraveled the mystery of the disco clams flashing “lips”. Most people assumed the glowing mantle was the result of bio-luminescence, but Lindsey Dougherty has found it is caused by something else entirely.
In work that unmasks some of the magic behind memristors and "resistive random access memory," or RRAM, researchers have shown that the metal particles in memristors don't stay put as previously thought. The findings have broad implications for the semiconductor industry and beyond. They show, for the first time, exactly how some memristors remember.
Plasmon tunneling is a quantum-mechanical effect where electrons rapidly oscillate across very closely-spaced metal structures. Using a Titan scanning/transmission electron microscope developed and made by FEI Company, the scientists were able to not only observe this new phenomenon directly, but also control the frequency of the tunneling currents by placing single layers of different molecules between the closely-spaced metal particles.
Oak Ridge National Laboratory has launched the Institute for Functional Imaging of Materials to accelerate discovery, design and deployment of new materials. The institute will meld world-class capabilities in imaging, high-performance computing, materials science and other scientific disciplines to probe materials.
Researchers at the Univ. of Michigan have obtained the first 3-D snapshots of the "assembly line" within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.
Physicists in Germany have developed a process to generate improved lenses for x-ray microscopy that provide both better resolution and higher throughput. To accomplish this, they have 3-D x-ray optics for volume diffraction that consist of on-chip stacked Fresnel zone plates. These nanostructures focus the incident x-rays much more efficiently and enable improved spatial resolution below 10 nm.
A new facility for using protons to take microscopic images has been commissioned at the ring accelerator of the GSI Helmholtz Centre for Heavy Ion Research in Darmstadt, Germany. Protons, like neutrons, are the building blocks of atomic nuclei. Similar to x-rays, they can be used to radiograph objects, generating images of them. Protons are able to penetrate hot dense matter that can't be examined with light or x-rays.
The term “crowdsourcing” was coined in 2006 and since then has seen its definition broadened to a wide range of activities involving a network of people. A challenging problem that might benefit from crowdsourcing, according to recently published research, is the phase problem in x-ray crystallography. Retrieving the phase information has plagued many scientists for decades when trying to determine the crystal structure of a sample.
In semiconductor-based components, high mobility of charge-carrying particles is important. In organic materials, however, it is uncertain to what degree the molecular order within the thin films affects the mobility and transport of charge carriers. Using a new imaging method, researchers have shown that thin-film organic semiconductors contain regions of structural disorder that could inhibit the transport of charge and limit efficiency.
Tomography enables the interior of a vast range of objects to be depicted in 3-D. Until now, relevant details on a scale of a few nanometers were only visible with tomography methods that required very thin samples. With the aid of a special prototype light source in Switzerland, researchers have now achieved a 3-D resolution of 16 nm on a nanoporous glass test sample, a feat that is unmatched for x-ray tomography.
Researchers in Germany have converted the frequencies of droplets flowing through thin channels into musical notes. This is more than just a gimmick: The fact that droplets can be controlled so precisely that they become musical instruments means they are also of interest with regard to medical diagnostics applications.
Atomic-scale snapshots of a bimetallic nanoparticle catalyst in action have provided insights that could help improve the industrial process by which fuels and chemicals are synthesized from natural gas, coal or plant biomass. A multinational laboratory collaboration has taken the most detailed look ever at the evolution of platinum/cobalt bimetallic nanoparticles during reactions in oxygen and hydrogen gases.
- Page 1