Univ. of California, Los Angeles biochemists have created the largest-ever protein that self-assembles into a molecular “cage.” The research could lead to synthetic vaccines that protect people from the flu, HIV and other diseases. At a size hundreds of times smaller than a human cell, it also could lead to new methods of delivering pharmaceuticals inside of cells, or to the creation of new nanoscale materials.
A major challenge faced by the pharmaceutical industry has been how to rationally design and select protein molecules to create effective biologic drug therapies while reducing unintended side effects—a challenge that has largely been addressed through costly guess–and–check experiments. Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard Univ. offer a new approach.
As the installation of photovoltaic solar cells continues to accelerate, scientists are looking for inexpensive materials beyond the traditional silicon that can efficiently convert sunlight into electricity. Theoretically, iron pyrite could do the job, but when it works at all, the conversion efficiency remains frustratingly low. Now, a Univ. of Wisconsin-Madison research team explains why that is.
Testing for ovarian cancer or the presence of a particular chemical could be almost as simple as distinguishing an F sharp from a B flat, thanks to a new microscopic acoustic device that has been dramatically improved by scientists at Argonne National Laboratory. The device, known as a surface acoustic wave (SAW) sensor, detects frequency changes in waves that propagate through its crystalline structure.
Massachusetts Institute of Technology chemists have developed new nanoparticles that can simultaneously perform magnetic resonance imaging (MRI) and fluorescent imaging in living animals. Such particles could help scientists to track specific molecules produced in the body, monitor a tumor’s environment, or determine whether drugs have successfully reached their targets.
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great therapeutic potential to treat a number of diseases, especially cancer and pandemic viruses. The problem is delivery: It’s extremely difficult to get RNAi drugs inside the cells in which they are needed.
Researchers at the Univ. of Georgia have discovered that a chemical compound commonly found in coffee may help prevent some of the damaging effects of obesity. In a recently published paper published, scientists found that chlorogenic acid, or CGA, significantly reduced insulin resistance and accumulation of fat in the livers of mice who were fed a high-fat diet.
Researchers at the Univ. of California, Los Angeles Henry Samueli School of Engineering and Applied Science have developed a more efficient way to turn methanol into useful chemicals, such as liquid fuels, and that would also reduce carbon dioxide emissions. Methanol, which is a product of natural gas, is well-known as a common “feedstock” chemical.
A team of Univ. of Houston chemistry researchers have developed a molecule that assembles spontaneously into a lightweight structure with microscopic pores capable of binding large quantities of several potent greenhouse gases. While carbon dioxide presents the biggest problem, several other compounds are hundreds or thousands of times more potent in their greenhouse effect per unit of mass.
The editors of R&D Magazine have announced the opening of the 2015 R&D 100 Awards entry process. The R&D 100 Awards have a 50 plus year history of awarding the 100 most technologically significant products of the year. Past winners have included sophisticated testing equipment, innovative new materials, chemistry breakthroughs, biomedical products, consumer items, high-energy physics and more.
Chemists at the Univ. of Basel have succeeded in twisting a molecule by combining molecular strands of differing lengths. The longer strand winds around a central axis like a staircase banister, creating a helical structure that exhibits special physical properties. The chemistry of all substances is to a large extent defined by their spatial arrangement.
Nanomedicine is offering patients a growing arsenal of therapeutic drugs for a variety of diseases, but often at a cost of thousands of dollars a month. Generics could substantially reduce the price tag for patients—if only there were a well-defined way to make and regulate them. An article in Chemical & Engineering News (C&EN) details the challenges on the road to generic nanodrugs.
The “surfactant” chemicals found in samples of fracking fluid collected in five states were no more toxic than substances commonly found in homes, according to a first-of-its-kind analysis by researchers at the Univ. of Colorado Boulder. Fracking fluid is largely comprised of water and sand, but oil and gas companies also add a variety of other chemicals, including surfactants.
Researchers have demonstrated a new process to convert all biomass into liquid fuel, and the method could make possible mobile processing plants. The researchers at Purdue Univ. filed a patent application on the concept in 2008 and have now demonstrated that it works in laboratory experiments.
Global warming is likely playing a bigger role than previously thought in dead zones in oceans, lakes and rivers around the world and it's only going to get worse, according to a new study. Dead zones occur when fertilizer runoff clogs waterways with nutrients, such as nitrogen and phosphorous. That leads to an explosion of microbes that consumes oxygen and leaves the water depleted of oxygen, harming marine life.
Chemists at The Scripps Research Institute and the Shanghai Institute of Organic Chemistry have described a method for creating and modifying organic compounds that overcomes a major limitation of previous methods. The advance opens up a large number of novel chemical structures for synthesis and evaluation, for example, as candidate pharmaceuticals.
Photosynthesis is probably the most well-known aspect of plant biochemistry. It enables plants, algae and select bacteria to transform the energy from sunlight during the daytime into chemical energy in the form of sugars and starches (as well as oils and proteins), and it involves taking in carbon dioxide from the air and releasing oxygen derived from water molecules.
Scientists believe that until about 2.4 billion years ago there was little oxygen in the atmosphere. Evidence in support of this hypothesis comes from studies of sulfur isotopes preserved in the rock record. But the sulfur isotope story has been uncertain because of the lack of key information that has now been provided by a new analytical technique developed by a team of Caltech geologists and geochemists.
The Earth’s ancient oceans held much lower concentrations of sulfate— a key biological nutrient— than previously recognized, according to new research.
Researchers led by David Thompson, president of Aten Biotherapeutics and a professor in Purdue's Department of Chemistry, are developing controlled-release imaging agents that allow for a longer, safer imaging session.
From water marks to colored threads, governments are constantly adding new features to paper money to stay one step ahead of counterfeiters. Now a longhorn beetle has inspired yet another way to foil cash fraud, as well as to produce colorful, changing billboards and art displays. In ACS Nano, researchers report a new kind of ink that mimics the beetle’s color-shifting ability in a way that would be long-lasting and difficult to copy.
Plants bask in the sun and need its light to live, but they also coat themselves in a natural sunscreen like a sunbather on the beach, protecting themselves from damaging rays. A new study examined the properties and mechanics of the molecule plants use to absorb harmful ultraviolet-B radiation, and its SPF rating would be off the charts.
Univ. of Utah engineers developed the first room-temperature fuel cell that uses enzymes to help jet fuel produce electricity without needing to ignite the fuel. These new fuel cells can be used to power portable electronics, off-grid power and sensors. A study of the new cells appears online in ACS Catalysis.
Scientists disclosed a new method to convert lignin, a biomass waste product, into simple chemicals. The innovation is an important step toward replacing petroleum-based fuels and chemicals with biorenewable materials. Lignin is the substance that makes trees and cornstalks sturdy, and it accounts for nearly 30% of the organic carbon in the biosphere.
Researchers in Germany have employed micro-FTIR and ATR-FTIR spectroscopy to determine precisely the type and source of microplastics found in the wastewater of a regional water association in Lower Saxony. With these infrared imaging methods, it is now possible to specifically classify plastics, such as those used in toothpaste, cosmetics, fleece jackets and packaging.