Scientists have discovered that the human brain can produce new neurons, but exactly how those cells are produced and what purpose they serve are not well understood. Now a study by Yale Univ. researchers shows that key developmental factors that control the formation of blood vessels are also necessary for activating brain stem cells.
In recent years, scientists have found a surprising a connection between some people with autism and certain cancer patients: They have mutations in the same gene, one that codes for a protein critical for normal cellular health. Now scientists have reported in Biochemistry that the defects reduce the activity and stability of the protein. Their findings could someday help lead to new treatments for both sets of patients.
The size of the human brain expanded dramatically during the course of evolution, imparting us with unique capabilities to use abstract language and do complex math. But how did the human brain get larger than that of our closest living relative, the chimpanzee, if almost all of our genes are the same?
Pesticide sprays and baits are common tactics for managing pest ants. But sprays can have little long-term impact and carry environmental costs such as chemical contamination of soil and water sources. Water-storing crystals known as hydrogels can effectively deliver pesticide bait to invasive Argentine ants, quickly decimating a colony.
Chemical engineers have designed a new type of self-healing hydrogel that could be injected through a syringe. Such gels, which can carry one or two drugs at a time, could be useful for treating cancer, macular degeneration, or heart disease, among other diseases, the researchers say.
Single-letter genetic variations within parts of the genome once dismissed as 'junk DNA' can increase cancer risk through wormhole-like effects on far-off genes, new research shows.
Research concludes that Earth's infrequent but predictable path around and through our Galaxy's disc may have a direct and significant effect on geological and biological phenomena occurring on Earth.
Terpenes and their derivatives exert important biological and pharmaceutical functions. Starting out from a few basic building blocks nature elegantly builds up complex structures. Chemically particularly challenging are bridged ring systems such as eucalyptol. Chemists at the Technical Univ. Munich have developed a catalyst that initiates the formation of such compounds.
Our susceptibility to disease depends both on the genes that we inherit from our parents and on our lifetime experiences. These two components—nature and nurture—seem to affect very different processes in the context of Alzheimer's disease, according to a new study published in Nature.
Electrical impulses play an important role in cells of the human body. For example, neurons use these impulses to transmit information along their branches and the body also uses them to control the contraction of muscles. The impulses are generated when special channel proteins open in the outer envelope of the cells, allowing charged molecules (ions) to enter or exit the cell. These proteins are referred to as ion channels.
Researchers have long sought alternatives to morphine that curb its side effects, including dependency, nausea and dizziness. Now, an experiment at SLAC National Accelerator Laboratory has supplied the most complete atomic-scale map of such a compound docked with a cellular receptor that regulates the body’s pain response and tolerance.
At least five mass extinction events have profoundly changed the history of life on Earth. But a new study led by researchers at the Univ. of Gothenburg shows that plants have been very resilient to those events. For over 400 million years, plants have played an essential role in almost all terrestrial environments and covered most of the world's surface.
A team of chemists, biochemists and mathematicians at the Univ. of Bristol have published a paper which explores how protein structures are stabilized. There are many forces that hold together the 3-D, functional structures of proteins. Despite considerable effort, understanding of these forces is still quite rudimentary.
Facing a challenge akin to solving a 1,000-piece jigsaw puzzle while blindfolded, and without touching the pieces, many structural biochemists thought it would be impossible to determine the atomic structure of a massive cellular machine called the nuclear pore complex, which is vital for cell survival. But after 10 years of attacking the problem, a team recently solved almost a third of the puzzle.
An international research group led by a team at the University of Adelaide has made what they believe could be the biggest discovery into cerebral palsy in 20 years.
Scientists have extensive knowledge of how mutations of single genes during evolution can have a fitness cost or benefit for the host organism. However, genes are often embedded into complex regulatory networks. The role of these gene networks in evolution is less well understood.
After using optical tweezers to squeeze a tiny bead attached to the outside of a human stem cell, researchers now know how mechanical forces can trigger a key signaling pathway in the cells. The squeeze helps to release calcium ions stored inside the cells and opens up channels in the cell membrane that allow the ions to flow into the cells, according to the study led by Univ. of California, San Diego bioengineer Yingxiao Wang.
Mice genetically deficient in serotonin, a crucial brain chemical implicated in clinical depression, are more vulnerable than their normal littermates to social stressors, according to a Duke Univ. study. Following exposure to stress, the serotonin-deficient mice also did not respond to a standard antidepressant, fluoxetine (Prozac), which works by boosting serotonin transmission between neighboring neurons.
A collaborative study led by scientists from the Mechanobiology Institute and the National Univ. of Singapore has revealed the mechanical forces that drive epithelial wound healing in the absence of cell supporting environment. This research was published in Nature Communications.
Brigham Young Univ. biologist Jonathan Alder has a startling secret he doesn’t freely share: he knows when most of us are going to die. Okay, he doesn’t know exactly the day or time, but he has a pretty good idea, thanks to his research on tiny biological clocks attached to our chromosomes. These DNA end caps, called telomeres, are the great predictors of life expectancy: the shorter your telomeres, the shorter your lifespan.
A more accurate view of the structure of the oxygen-evolving complex that splits water during photosynthesis is now in hand thanks to a study involving researchers from the RIKEN SPring-8 Center, Okayama Univ. and the Japan Science and Technology Agency. The new model of natural photosynthesis provides a blueprint for synthesizing water-splitting catalysts that mimic this natural process.
Proteins are the building blocks of all living things, and they exist in virtually unlimited varieties, most of whose highly complex structures have not yet been determined. Those structures could be key to developing new drugs or to understanding basic biological processes. But figuring out the arrangement of atoms in these complicated, folded molecules usually requires getting them to form crystals large enough to be observed in detail.
A team of Carnegie Institute scientists have found “beautifully preserved” 15-million-year-old thin protein sheets in fossil shells from southern Maryland. The team collected samples from Calvert Cliffs, along the shoreline of the Chesapeake Bay, a popular fossil collecting area. They found fossilized shells of a snail-like mollusk called Ecphora that lived in the mid-Miocene era.
The more scientists study pigeons, the more they learn how their brains operate in ways not so different from our own. In a new study from the Univ. of Iowa, researchers found that pigeons can categorize and name both natural and manmade objects. These birds categorized 128 photographs into 16 categories, and they did so simultaneously.
More than 100 researchers from around the world have collaborated to craft a request that could fundamentally alter how the antibodies used in research are identified, a project potentially on the scale of the now-completed Human Genome Project.