By combining two highly innovative experimental techniques, scientists at the Univ. of Illinois at Urbana-Champaign have for the first time simultaneously observed the structure and the correlated function of specific proteins critical in the repair of DNA, providing definitive answers to some highly debated questions, and opening up new avenues of inquiry and exciting new possibilities for biological engineering.
3D printing has been used to make everything from cars to medical implants. Now, Univ. of...
How does climate change affect the occurrence and distribution of species? This is a key...
Zinc deficiency, long associated with numerous diseases like certain cancers, can lead to activation of the Hedgehog signaling pathway, a biomolecular pathway that plays essential roles in developing organisms and in diseases, according to new research at Rensselaer Polytechnic Institute.
Researchers from North Carolina State Univ. and the Univ. of Colorado, Boulder, have developed a statistical model that allows them to tell where a dust sample came from within the continental U.S. based on the DNA of fungi found in the sample.
Nowhere is the adage "form follows function" more true than in the folded chain of amino acids that makes up a single protein macromolecule. But proteins are very sensitive to errors in their genetic blueprints. One single-letter DNA "misspelling" (called a point mutation) can alter a protein's structure or electric charge distribution enough to render it ineffective or even deleterious.
When scientists exposed pregnant mice to levels of bisphenol A (BPA) equivalent to those considered safe in humans, three generations of female mouse offspring experienced significant reproductive problems, including declines in fertility, sexual maturity and pregnancy success, the scientists report in Toxicology and Applied Pharmacology.
Translational research is a paradigm for research designed to enable innovative thinking by leveraging the benefits of collaboration. First emerging in the mid-1990s in reference to cancer studies spanning basic science, over the past two decades the definition has broadened and evolved.
The mesh coating is among a suite of nature-inspired nanotechnologies under development at Ohio State and described in two papers in Nature Scientific Reports. Potential applications range from cleaning oil spills to tracking oil deposits underground.
Scientists focused on producing biofuels more efficiently have a new powerful data set to help them study the DNA of microbes that fuel bioconversion and other processes. In a recently published paper, researchers describe methods and results for sequencing the Clostridium autoethanogenum bacterium. These and other microorganisms play important roles in biofuels, agriculture, food production, the environment, health and disease.
Those lost car keys that were an annoyance in your 30s can spark major anxiety in your 60s. Turns out it's pretty normal: The brain ages just like the rest of your body, says a new report that urges Americans to take steps to keep sharp in their senior years. The prestigious Institute of Medicine examined what scientists know about "cognitive aging," changes in mental functioning as we get older.
Skin is remarkably resistant to tearing and a team of researchers from the Univ. of California, San Diego and the Lawrence Berkeley National Laboratory now have shown why. Using powerful x-ray beams and electron microscopy, researchers made the first direct observations of the micro-scale mechanisms that allow skin to resist tearing.
A new collaborative study describes a way that lung tissue can regenerate after injury.
The step forward follows research by the Univs. of Warwick and Cambridge and the unexpected discovery of a previously unknown arrangement of molecules in plant cell walls. The researchers investigated the polymer xylan, which comprises a third of wood matter.
With rising populations and changing climate conditions, the need for resilient and reliable crops has never been greater. Nitrogen, an essential element for plant growth, is often woefully absent in heavily farmed land. Earth’s atmosphere offers an overabundance of nitrogen, but how can it be safely and sustainably transferred into the soil? Nitrogen-eating bacteria may be the answer.
A new device developed by Univ. of California, Los Angeles, engineers and doctors may eventually help scientists study the development of disease, enable them to capture improved images of the inside of cells and lead to other improvements in medical and biological research.
A great deal of public attention in the past couple of years has been showered on complexes of bacterial proteins known as “CRISPR-Cas” for their potential use as a tool for editing DNA. Now, researchers with the Lawrence Berkeley National Laboratory are reporting that CRISPR-Cas complexes could also serve as an engineering tool for RNA, the molecule that translates DNA’s genetic instructions into the production of proteins.
Separating circulating cancer cells from blood cells for diagnostic, prognostic and treatment purposes may become much easier using an acoustic separation method and an inexpensive, disposable chip, according to a team of engineers from Penn State Univ.
Researchers are always searching for improved technologies, but the most efficient computer possible already exists. It can learn and adapt without needing to be programmed or updated. It has nearly limitless memory, is difficult to crash, and works at extremely fast speeds. It’s not a Mac or a PC; it’s the human brain. And scientists around the world want to mimic its abilities.
Life may seem precarious for the sea sponge known as Venus’ flower basket. Tiny, hair-like appendages made essentially of glass are all that hold the creatures to their seafloor homes. But fear not for these creatures of the deep. Those tiny lifelines, called basalia spicules, are fine-tuned for strength, according to new research led by Brown Univ. engineers.
Complex brain disorders, such as autism or schizophrenia, still puzzle scientists because their causes lie hidden in early events of brain development, which are still poorly understood. This is about to change thanks to research by Univ. of Toronto Profs. Ben Blencowe and Sabine Cordes, who have developed a powerful model that will allow researchers to better understand the physiology behind many disorders.
Have you ever wondered if your dad's fight with prostate cancer means you could face the same reality? Perhaps your family has several members who have struggled with obesity and you wonder if it's something you inherited or if it's caused by the environment. Maybe you have always wanted to learn where your ancestors came from beyond the basic paper trail. Good news: Researchers have an app for that.
When weighing the pluses and minuses of your skin add this to the plus column: Your skin, like that of all vertebrates, is remarkably resistant to tearing. Now, a collaboration of researchers at Lawrence Berkeley National Laboratory and the Univ. of California, San Diego, has shown why.
Researchers at the National Univ. of Singapore have discovered that the inherent handedness of molecular structures directs the behavior of individual cells and confers them the ability to sense the difference between left and right. This is a significant step forward in the understanding of cellular biology.
Scientists have found a way to measure the unseen toll that environmental stress places on living creatures, showing that they can rev up their metabolism to work more than twice as hard as normal to cope with change. Stresses from climate change such as rising temperatures and increasing ocean acidity can move an organism closer and closer to the brink of death without visible signs.
The decades worth of data that has been collected about the billions of neurons in the brain is astounding. To help scientists make sense of this “brain big data,” researchers at Carnegie Mellon Univ. have used data mining to create www.neuroelectro.org, a publicly available Website that acts like Wikipedia, indexing physiological information about neurons.
Researchers studying cancer and other invasive diseases rely on high-resolution imaging to see tumors and other activity deep within the body's tissues. Using a new high-speed, high-resolution imaging method, a team at Washington Univ. in St. Louis were able to see blood flow, blood oxygenation, oxygen metabolism and other functions inside a living mouse brain at faster rates than ever before.
Using high-performance computing and genetic engineering to boost the photosynthetic efficiency of plants offers the best hope of increasing crop yields enough to feed a planet expected to have 9.5 billion people on it by 2050, researchers report in Cell.
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