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R&D 100 Awards
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The Lead

Reducing the Pain

August 21, 2014 4:51 pm | Award Winners

Milliken and Company’s ASSIST Silver is a low-adherent antimicrobial dressing used primarily in burn care for the management of skin grafts. The dressing incorporates three primary features: Active Fluid Management (AFM) technology, an ionic silver antimicrobial and a low-adherent layer.

A Smart Solution to RNA Detection

August 21, 2014 4:37 pm | Award Winners

RNA detection traditionally requires transfection, laborious sample prep, RNA amplification and/...

TB Be Gone

August 21, 2014 4:27 pm | Award Winners

MDR-TB is a growing problem, estimated to kill 170,000 people annually and projected to infect...

Saving Childrens’ Lives

August 21, 2014 4:18 pm | Award Winners

Globally, 22 million infants aren’t receiving basic vaccines and 1.5 million children will die...

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Microarray for Complex Chemotyping

August 21, 2014 4:05 pm | Award Winners

Whether the application is biofuels, microbial ecological investigation or medical research, Lawrence Berkeley National Laboratory’s Berkeley Lab Multiplex Chemotyping Microarray (MCM) has proven to be the most powerful and precise system for investigations of biomass at the molecular level. MCM performs rapid chemical analyses of prospective biofuel crops and microbial communities by combining high-throughput micro-contact printing technology with high-fidelity vibrational spectroscopy and mass spectrometry.

Medical Tests for the Developing World

August 21, 2014 3:52 pm | Award Winners

Novilytic’s Noviplex Plasma Collection Card is a self-contained, blood-plasma sampling device used to volumetrically collect a plasma aliquot independent of whole blood application volumes. The Noviplex requires no power and circumvents requirements for venipuncture-phlebotomy training, needles, special vials and equipment, refrigeration and centrifugation normally associated with traditional plasma methods.

Powerful Single-output Laser

August 21, 2014 3:36 pm | Award Winners

Spectral beam combining (SBC) of fiber lasers offers a straightforward approach for power scaling. The approach exploits the broad gain bandwidth to enable large numbers of fiber laser channels to be combined with near-diffraction-limited beam quality. Rigorous application of SBC has allowed a development team including Lawrence Livermore National Laboratory, Lockheed Martin Laser and Sensor Systems and Advanced Thin Films to develop the EXtreme-power, Ultra-low-loss, Dispersive Element (EXUDE) optical element, the first-ever electrically efficient, near diffraction-limited 30-kW beam combined laser.

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Life Preserver for Fiber Lasers

August 21, 2014 3:19 pm | Award Winners

Isolators are used to block back-reflected light in a fiber laser. Conventional free-space fiber pigtailed isolators can only handle less than 1 W of back-reflected light, which accounts for the main cause of failure for most fiber laser systems. Estimates are that more than 60,000 fiber lasers are at risk of this type of failure, costing operators $75 million a year. With its All-Fiber Isolator, AdValue Photonics Inc. can now provide fiber laser system operators with the ability to handle more than 200 W of back-reflected light.

LEDs Challenge Xenon Lamps

August 21, 2014 3:04 pm | Award Winners

Physicians and scientists have two major options when it comes to solid-state lighting for applications in fiber optics: conventional lamps, using xenon gas, or LEDs. The lamps, which may be used for tasks ranging from endoscopy in medical settings or borescopy for jet engine inspection, must supply a high level of consistent, high-quality light. Until recently, LEDs couldn’t generate enough high-quality lumens to compete with xenon lamps. But OSRAM GmbH and Osram Sylvania have jointly developed a new white-light LED module based on laser technology.

A Micro Step Forward

August 21, 2014 1:26 pm | Award Winners

Micro GC technology is a proven technology for gas analysis in laboratory, pilot plant and field applications. The principle benefit of Micro GC over a traditional benchtop gas chromatography (GC) is speed of analysis. INFICON’s temperature-programmable Micro GC Fusion has further improved the Micro GC speed advantage, cutting the average analysis time over an isothermal Micro GC in half.

Synching Water Quality Results

August 21, 2014 1:08 pm | Award Winners

With the capacity to test over 30 of the most critical water-quality parameters across multiple industries through a four-step process, Industrial Test SystemseXact iDip is the first water testing photometer that provides seamless data transmission and live syncing of test results using Bluetooth at an affordable price.

An Analytical Balancing Act

August 21, 2014 12:59 pm | Award Winners

Mettler Toledo’s XPE205 analytical balance provides unique performance in analytical weighing and support for the highest requirements for safety, efficiency and ease of compliance. These balances feature two quality management features, the StatusLight and StaticDetect, which take the worry out of weighing and provide users with a high level of trust in their results.

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microTLC Fills Gaps in Detection

August 21, 2014 11:57 am | Award Winners

Filling major gaps in field testing for explosives and narcotics, Lawrence Livermore National Laboratory’s microTLC is a miniaturized, field-portable thin layer chromatography (TLC) kit used to detect and identify unknowns. Originally developed to identify military explosives, the device has been modified to also identify and determine the purity of illicit drugs, pesticides and other compounds.

Getting to the Depth of Cell Culture

August 21, 2014 11:37 am | Award Winners

EMD Millipore’s Clarisolve depth filters are specifically tuned to the particle size distribution of various pretreatment methodologies enabling a fast and efficient way to clarify high-density streams and easily transfer processes from upstream to downstream without the use of centrifugation.

A Solid Chromatography Column Solution

August 21, 2014 11:19 am | Award Winners

Waters Corp. has designed CORTECS 1.6 µm Columns to pair seamlessly with UPLC system technology to deliver the highest performance yet for reversed-phase and HILIC separations. CORTECS features a new, patent-pending charged surface modification that improves the peak shape and loading capacity of basic analytes when run in low-ionic strength acidic mobile phases, such as 0.1% formic acid.

Faster Peptide Synthesis

August 21, 2014 11:07 am | CEM Corporation | Award Winners

Peptide and protein therapeutics are important drug candidates due to their ubiquitous nature as biological molecules, as well as their ability to control all aspects of cellular function along with many facets of intercellular communication. CEM Corp.’s Liberty Blue automated microwave peptide synthesizer will streamline the peptide synthesis process for pharmaceutical, biotech and academic researchers, enabling them to produce peptides for drug discovery and studies in the field of life sciences in a manner that is more efficient, cost effective, faster and better for the environment.

Water-cooled Perfection

August 20, 2014 4:47 pm | Award Winners

Hewlett-Packard and National Renewable Energy Laboratory’s HP Apollo supercomputing platform approaches HPC from an entirely new perspective as the system is cooled directly with warm water. This is done through a “dry-disconnect” cooling concept that has been implemented with the simple but efficient use of heat pipes. Unlike cooling fans, which are designed for maximum load, the heat pipes can be optimized by administrators.

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Chaos that Brings Order

August 20, 2014 4:29 pm | Award Winners

Oak Ridge National Laboratory’s DUCCS is ultra-efficient software that utilizes highly parallel chaotic map computations to quickly (in a few minutes) and efficiently detect component faults in computing units, memory elements and interconnects of hybrid CPU-GPU computing systems.

New Playing Field for Localization Microscopy

August 20, 2014 3:58 pm | Carl Zeiss | Award Winners

Prior to the introduction of the ELYRA P.1 with 3D PALM by Carl Zeiss Microscopy LLC, commercially available 3-D localization techniques resulted in images where the resolution was not uniform throughout a small capture volume due to location dependent localization precision. The utilization of these techniques would not allow researchers to model biological structures in a fast and reliable manner over large capture volumes.

Indentation Tool for Biomedicine

August 20, 2014 3:40 pm | Award Winners

Hysitron Inc. developed a nano- to microscale biomechanical test instrument with load noise floor of less than 30 nN that fills this gap by uniting indentation tools with an optically configured microscope. The instrument combines powerful optical imaging with in-situ mechanical characterization and high resolution scanning probe imaging to allow researchers to directly correlate optical characterization with mechanical properties of biological samples.

Pocket Microscope

August 20, 2014 3:28 pm | Award Winners

Most microscopes are expensive, built with high-quality metals, optics and electronics to perform with high accuracy. However, not all useful microscopes need to be built this way, and Stanford Univ. has taken this premise to the extreme with a microscope that is made with parts that cost less than $1. A frugal, origami-based solution, the Foldscope can be assembled from 2-D media in less than 10 min, yet can provide more than 2,000X magnification, which is submicrometer resolution.

Lifting Limits on Thermal AFM

August 20, 2014 3:18 pm | Award Winners

With the introduction of the VertiSense Scanning Thermal Microscopy Module, Applied NanoStructures Inc. has brought a new level of flexibility to thermal imaging using an atomic force microscope (AFM). The probe module’s sensor design provides, for the first time, absolute and nanoscale temperature measurement during the application of scanning thermal microscopy (SThM), which captures both topographical and thermal images.

Beating the Diffraction Limit

August 20, 2014 3:05 pm | Award Winners

Super-resolution microscopy has emerged as a leading subcellular imaging technique over the past decade, bringing tagged nanoscopic biological elements into full view for researchers. Leica Microsystems has been a development leader in this segment of microscopy, and one of its newest products, the TCS SP8 STED 3X, brings a new element to imaging capabilities.

Nanoscale Measuring, Without Harm

August 20, 2014 2:42 pm | Award Winners

Engineers at Hitachi Ltd.’s Yokohama Research Laboratory have achieved a spatial resolution of 3 nm and imaging repeatability of 0.5 nm in the new Plasmon‐Excitation Optical Scanning Probe Microscope (Optical SPM), which allows users to obtain difficult nondestructive measurements of nanoscale devices.

Rapid Non-contact 3-D Measurements

August 20, 2014 2:26 pm | KEYENCE Corporation | Award Winners

Contact-type measurement systems are often used to acquire accurate 3-D measurements. However, multiple adjustments, such as probe and sample placements, must be set prior to the measurement function and the user is left with a single data line for future evaluation. Keyence Corp. conceived its VR-3000 Series One-shot 3D Measurement Macroscope as a way to reduce this time investment: It achieves height information data capture in just 5 sec on parts up to 10 mm and has a measurement repeatability of 0.5 μm. This is a first in non-contact 3-D inspection and measurement.

Flattening Yields Faster CT

August 20, 2014 2:14 pm | Award Winners

In 2012, more than 85 million computed tomography (CT) scans were performed in the U.S. Of these, 16% were thoracic scans. Up to now, this has been done manually and sequentially in what is a tedious, lengthy and error-prone process. Engineers at Siemens Corporate Technology and Siemens Healthcare, Computed Tomography have launched a new solution to save radiologists time and increase diagnostic confidence for thoracic bone assessment.

Corn Fears No Drought

August 20, 2014 1:57 pm | Award Winners

According to the U.S. Drought Monitor, many states across the U.S. currently display drought conditions ranging from severe to exceptional, including regions in the Western Great Plains. In 2013, corn farmers in these areas were able to plant deeper roots and produce strong yields with Monsanto’s Genuity DroughtGard Hybrids.

Cleaning Up Catastrophic Messes

August 20, 2014 1:50 pm | Award Winners

Hitachi Research Laboratory and Hitachi-GE Nuclear Energy Ltd joined together to develop the Hitachi Cs-Sr simultaneous adsorbent to treat radionuclide-contaminated water being stored at the Fukushima Daiichi Nuclear Power Station. This adsorbent is the first of its kind that can simultaneously adsorb radioactive cesium (Cs) and radioactive strontium (Sr) dissolved in water at a high adsorption rate of 99% or better, satisfying the standards for drinking water established by the Japanese Ministry of Health, Labor and Welfare (radiation dose of 10 Bq/L or less) using half the quantity of conventional adsorbents.

Clean Water for All

August 20, 2014 12:09 pm | Award Winners

Clean Filtration Technologies LLC, a subsidiary of The Dow Chemical Company, has developed the TEQUATIC PLUS fine particle filter. The filter is a disruptive technology that unlike conventional filters can clean itself. Constant fouling and plugging are things of the past, replaced by high uptime and low maintenance.

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