The human body contains trillions of cells, all derived from a single cell. That single cell contains all the genetic information needed to develop into a human, and passes identical copies of that information to each new cell as it divides into the many diverse types of cells. If each cell is genetically identical, however, how does it grow to be a skin, blood, nerve, bone, or other type of cell?
Thermoelectric materials can be used to turn waste heat into electricity or to provide refrigeration without any liquid coolants, and a research team from the University of Michigan has found a way to nearly double the efficiency of a particular class of them that's made with organic semiconductors.
Cancer cells are wily, well-traveled adversaries, constantly side-stepping treatments to stop their spread. But, for the first time, scientists at the University of Michigan have decoded the molecular chatter that ramps certain cancer cells into overdrive and can cause tumors to metastasize throughout the body.
Long-term exposure to air pollution may be linked to heart attacks and strokes by speeding up atherosclerosis, or "hardening of the arteries," according to a University of Michigan public health researcher and colleagues from across the U.S.
Using a new laboratory geochemical technique to analyze heavy isotopes of carbon and oxygen in fossil snail shells, scientists have gained insights into an abrupt climate shift that transformed the planet nearly 34 million years ago. At that time, the Earth switched from a warm and high-carbon dioxide "greenhouse" state to the lower-carbon dioxide, variable climate of the modern "icehouse" world.
The explosive popularity of wireless devices is increasingly clogging the airwaves, resulting in dropped calls, wasted bandwidth, and botched connections. New software, called GapSense, being developed at the University of Michigan works like a stoplight to control the traffic and dramatically reduce interference.
Deep inside your brain, a legion of stem cells lies ready to turn into new brain and nerve cells whenever and wherever you need them most. But what happens to the garbage within cells that keeps them in a stem-cell state. Years of mouse research has allowed researchers at the University of Michigan to discover how autophagy keeps neural stem cells ready to replace damaged brain and nerve cells.
In a development that could make the advanced form of secure communications known as quantum cryptography more practical, University of Michigan researchers have demonstrated a simpler, more efficient single-photon emitter that can be made using traditional semiconductor processing techniques.
One of the major obstacles to growing new organs—replacement hearts, lungs, and kidneys—is the difficulty researchers face in building blood vessels that keep the tissues alive, but new findings from the University of Michigan could help overcome this roadblock.
Wouldn't it be convenient if you could reverse the rusting of your car by shining a bright light on it? It turns out that this concept works for undoing oxidation on copper nanoparticles, and it could lead to an environmentally friendly production process for an important industrial chemical, University of Michigan engineers have discovered.
Low-energy terahertz radiation could potentially enable doctors to see deep into tissues without the damaging effects of X-rays, or allow security guards to identify chemicals in a package without opening it. But it's been difficult for engineers to make powerful enough systems to accomplish these promising applications. Now an electrical engineering research team at the University of Michigan has developed a laser-powered terahertz source and detector system that transmits with 50 times more power and receives with 30 times more sensitivity than existing technologies.
Semiconducting polymers are an unruly bunch, but University of Michigan engineers have developed a new method for getting them in line that could pave the way for cheaper, greener, "paint-on" plastic electronics.
A common test used to determine mercury exposure from dental amalgam fillings may significantly overestimate the amount of the toxic metal released from fillings, according to University of Michigan researchers. Scientists agree that dental amalgam fillings slowly release mercury vapor into the mouth. But both the amount of mercury released and the question of whether this exposure presents a significant health risk remain controversial.
Running cockroaches start to recover from being shoved sideways before their dawdling nervous system kicks in to tell their legs what to do, researchers have found. These new insights on how biological systems stabilize could one day help engineers design steadier robots and improve doctors' understanding of human gait abnormalities.
Traces of water have been detected within the crystalline structure of mineral samples from the lunar highland upper crust obtained during the Apollo missions, according to a University of Michigan researcher and his colleagues. The lunar highlands are thought to represent the original crust, crystallized from a magma ocean on a mostly molten early moon. The new findings indicate that the early moon was wet and that water there was not substantially lost during the moon's formation.
Ancient carbon trapped in Arctic permafrost is extremely sensitive to sunlight and, if exposed to the surface when long-frozen soils melt and collapse, can release climate-warming carbon dioxide gas into the atmosphere much faster than previously thought.
Researchers at the University of Michigan's Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment of asthma and other uses, also reverses obesity, diabetes, and fatty liver in mice.
Many medically minded researchers are in hot pursuit of designs that will allow drug-carrying nanoparticles to navigate tissues and the interiors of cells, but University of Michigan engineers have discovered that these particles have another hurdle to overcome: escaping the bloodstream. According to their work, the immune system can't get rid of some of the promising drug carriers quickly.
When researchers sequence the RNA of cancer cells, they can compare it to normal cells and see where there is more RNA. That can help lead them to the gene or protein that might be triggering the cancer. But other than spotting a few known instigators, what does it mean? Is there more RNA because it's synthesizing too quickly or because it's not degrading fast enough? What part of the biological equilibrium is off? After more than a decade of work, researchers have developed a technique to help answer those questions.
A new way of making crystalline silicon, developed by University of Michigan researchers, could make this crucial ingredient of computers and solar cells much cheaper and greener. The researchers discovered a way to make silicon crystals, directly at just 180 F, the internal temperature of a cooked turkey, by taking advantage of a phenomenon seen in your kitchen.
A nanoscale coating that's at least 95% air repels the broadest range of liquids of any material in its class, causing them to bounce off the treated surface, according to the University of Michigan engineering researchers who developed it.
Researchers used electricity on certain regions in the brain of a patient with chronic, severe facial pain to release an opiate-like substance that's considered one of the body's most powerful painkillers. The findings expand on previous work done at the University of Michigan, Harvard University, and the City University of New York where researchers delivered electricity through sensors on the skulls of chronic migraine patients, and found a decrease in the intensity and pain of their headache attacks.
A carbon nanotube-coated lens that converts light to sound can focus high-pressure sound waves to finer points than ever before. The University of Michigan engineering researchers who developed the new therapeutic ultrasound approach say it could lead to an invisible knife for noninvasive surgery.
A glass plate with a nanoscale roughness could be a simple way for scientists to capture and study the circulating tumor cells that carry cancer around the body through the bloodstream. Engineering and medical researchers at the University of Michigan have devised such a set-up, which they say takes advantage of cancer cells' stronger drive to settle and bind compared with normal blood cells.
Fuel economy of all new vehicles sold in the United States remains at its highest level ever, while emissions are at a record low, say researchers at the University of Michigan Transportation Research Institute.