Researchers at the Univ. of Michigan have discovered how a previously unknown hormone serves as a messenger from fat cells to the liver and are investigating the potential of developing a new treatment for metabolic disorders. Jiandie Lin of the Life Sciences Institute described how in mice the hormone, NRG4, is secreted by so-called brown fat cells and communicates with the liver to regulate the conversion of sugar into fat.
In a step toward robots smaller than a grain of sand, Univ. of Michigan researchers have shown how chains of self-assembling particles could serve as electrically activated muscles in the tiny machines. So-called microbots would be handy in many areas. But several challenges lie between current technologies and science fiction possibilities. Two of the big ones are building the bots and making them mobile.
Researchers at the Univ. of Michigan have shown how a single neuron can perform multiple functions in a model organism, illuminating for the first time this fundamental biological mechanism and shedding light on the human brain. Investigators found that a neuron in C. elegans regulates both the speed and direction in which the worm moves.
Despite safety concerns about equipment failure, a majority of drivers on three continents have high expectations for autonomous vehicles. Building on an earlier study on public opinion regarding self-driving vehicles in the U.S., Great Britain and Australia, a team from the Univ. of Michigan Transportation Research Institute expanded their survey to include more than 1,700 respondents in India, China and Japan.
Scientists from North America, Europe and China published a paper that reveals important details about key transitions in the evolution of plant life on our planet. From strange and exotic algae, trees and flowers growing deep in steamy rainforests to the grains and vegetables we eat and the ornamental plants adorning our homes, all plant life on Earth shares over a billion years of history.
In a design that mimics a hard-to-duplicate texture of starfish shells, Univ. of Michigan engineers have made rounded crystals that have no facets. The team calls the crystals "nanolobes". The nanolobes' shape and the way they're made have promising applications. The geometry could potentially be useful to guide light in advanced LEDs, solar cells and non-reflective surfaces.
The discovery of a gene mutation that causes a rare premature aging disease could lead to the development of drugs that block the rapid, unstoppable cell division that makes cancer so deadly. Scientists at the Univ. of Michigan recently discovered a protein mutation that causes the devastating disease dyskeratosis congenita, in which precious hematopoietic stem cells can't regenerate and make new blood.
Researchers at the Univ. of Michigan have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods. They used the platform to identify a novel antibody that is undergoing further investigation as a potential treatment for breast, ovarian and other cancers.
Up to half of the water on Earth is likely older than the solar system itself, Univ. of Michigan astronomers theorize. The researchers' work helps to settle a debate about just how far back in galactic history our planet and our solar system's water formed. Were the molecules in comet ices and terrestrial oceans born with the system itself—in the planet-forming disk of dust and gas that circled the young sun 4.6 billion years ago?
Blue organic light-emitting diodes (OLEDs) are one of a trio of colors used in OLED displays such as smartphone screens and high-end TVs. In a step that could lead to longer battery life in smartphones and lower power consumption for large-screen televisions, researchers at the Univ. of Michigan have extended the lifetime of blue organic light emitting diodes by a factor of 10.
A potential way to treat muscular dystrophy directly targets muscle repair instead of the underlying genetic defect that usually leads to the disease. Muscular dystrophies are a group of muscle diseases characterized by skeletal muscle wasting and weakness. Mutations in certain proteins, most commonly the protein dystrophin, cause muscular dystrophy in humans and also in mice.
A new $1.9 million study at the Univ. of Michigan seeks to make low-dose computed tomography scans a viable screening technique by speeding up the image reconstruction from half an hour or more to just five minutes. The advance could be particularly important for fighting lung cancers, as symptoms often appear too late for effective treatment.
Just how much Arctic permafrost will thaw in the future and how fast heat-trapping carbon dioxide will be released from those warming soils is a topic of lively debate among climate scientists. To answer those questions, scientists need to understand the mechanisms that control the conversion of organic soil carbon into carbon dioxide gas. Until now, researchers believed that bacteria were largely responsible.
A speedy way to mimic the aging of materials inside nuclear reactors has matched all aspects of the damage sustained by a real reactor component for the first time. The method could help the U.S. and other countries stay ahead of potential problems in reactors that run for 40 years or more and also test materials for building advanced reactors.
While it's becoming commonplace for patients to see the results of laboratory work electronically, a new Univ. of Michigan study suggests that many people may not be able to understand what those numbers mean. The research found that people with low comprehension of numerical concepts—or numeracy—and low literacy skills were less than half as likely to understand whether a result was inside or outside the reference ranges.
An outline of Marilyn Monroe's iconic face appeared on the clear, plastic film when a researcher fogs it with her breath. Terry Shyu, a doctoral student in chemical engineering at the Univ. of Michigan, was demonstrating a new high-tech label for fighting drug counterfeiting. While the researchers don't envision movie stars on medicine bottles, they used Monroe's image to prove their concept.
Imagine you're fighting for your life but no matter how hard you hit, your opponent won't go down. The same can be said of highly treatment-resistant cancers, such as head and neck cancer, where during radiation and chemotherapy some cancer cells repair themselves, survive and thrive. Head and neck cancer is the sixth most common cancer in the world, but the late detection and treatment resistance result in a high mortality rate.
HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others. Yet, despite the breadth of infectivity, roughly 76% of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus.
Researchers have taken a major stride toward perfectly efficient lighting that is also relatively inexpensive and simple to make. The same material can also reveal the presence of water by changing color. Incandescent bulbs only turn 5% of the electricity they use into light, while fluorescent LEDs can produce light from up to 25% of the electrons that pass through them. Phosphorescent LEDs can turn every electron into a ray of light.
Biophysics researchers have used short pulses of light to peer into the mechanics of photosynthesis and illuminate the role that molecule vibrations play in the energy conversion process that powers life on our planet. The findings could potentially help engineers make more efficient solar cells and energy storage systems.
In work that unmasks some of the magic behind memristors and "resistive random access memory," or RRAM, researchers have shown that the metal particles in memristors don't stay put as previously thought. The findings have broad implications for the semiconductor industry and beyond. They show, for the first time, exactly how some memristors remember.
Researchers at the Univ. of Michigan have obtained the first 3-D snapshots of the "assembly line" within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.
Imaging and mapping of electric fields at radio frequencies (RF) currently requires the use of metallic structures such as dipoles, probes and reference antennas. To make such measurements efficiently, the size of these structures needs to be on the order of the wavelength of the RF fields to be mapped. This poses practical limitations on the smallest features that can be measured.
More Americans view global warming by what they see outside their windows and not scientific evidence, according to a Univ. of Michigan survey. While a majority of Americans still believe that global warming is occurring, the cold and snowy winter of 2014 created more disbelievers, according to the National Surveys on Energy and Environment.
Four major U.S. research universities have formed a technology consortium to improve the way in which educational content is shared across universities and ultimately delivered to students. Unizin will provide a common digital infrastructure that will allow member universities to work together to strengthen their traditional missions of education and research using the most innovative technology available today.