The discovery of a gene mutation that causes a rare premature aging disease could lead to the development of drugs that block the rapid, unstoppable cell division that makes cancer so deadly. Scientists at the Univ. of Michigan recently discovered a protein mutation that causes the devastating disease dyskeratosis congenita, in which precious hematopoietic stem cells can't regenerate and make new blood.
Researchers at the Univ. of Michigan have described a new approach to discovering potential cancer treatments that requires a fraction of the time needed for more traditional methods. They used the platform to identify a novel antibody that is undergoing further investigation as a potential treatment for breast, ovarian and other cancers.
Up to half of the water on Earth is likely older than the solar system itself, Univ. of Michigan astronomers theorize. The researchers' work helps to settle a debate about just how far back in galactic history our planet and our solar system's water formed. Were the molecules in comet ices and terrestrial oceans born with the system itself—in the planet-forming disk of dust and gas that circled the young sun 4.6 billion years ago?
Blue organic light-emitting diodes (OLEDs) are one of a trio of colors used in OLED displays such as smartphone screens and high-end TVs. In a step that could lead to longer battery life in smartphones and lower power consumption for large-screen televisions, researchers at the Univ. of Michigan have extended the lifetime of blue organic light emitting diodes by a factor of 10.
A potential way to treat muscular dystrophy directly targets muscle repair instead of the underlying genetic defect that usually leads to the disease. Muscular dystrophies are a group of muscle diseases characterized by skeletal muscle wasting and weakness. Mutations in certain proteins, most commonly the protein dystrophin, cause muscular dystrophy in humans and also in mice.
A new $1.9 million study at the Univ. of Michigan seeks to make low-dose computed tomography scans a viable screening technique by speeding up the image reconstruction from half an hour or more to just five minutes. The advance could be particularly important for fighting lung cancers, as symptoms often appear too late for effective treatment.
Just how much Arctic permafrost will thaw in the future and how fast heat-trapping carbon dioxide will be released from those warming soils is a topic of lively debate among climate scientists. To answer those questions, scientists need to understand the mechanisms that control the conversion of organic soil carbon into carbon dioxide gas. Until now, researchers believed that bacteria were largely responsible.
A speedy way to mimic the aging of materials inside nuclear reactors has matched all aspects of the damage sustained by a real reactor component for the first time. The method could help the U.S. and other countries stay ahead of potential problems in reactors that run for 40 years or more and also test materials for building advanced reactors.
While it's becoming commonplace for patients to see the results of laboratory work electronically, a new Univ. of Michigan study suggests that many people may not be able to understand what those numbers mean. The research found that people with low comprehension of numerical concepts—or numeracy—and low literacy skills were less than half as likely to understand whether a result was inside or outside the reference ranges.
An outline of Marilyn Monroe's iconic face appeared on the clear, plastic film when a researcher fogs it with her breath. Terry Shyu, a doctoral student in chemical engineering at the Univ. of Michigan, was demonstrating a new high-tech label for fighting drug counterfeiting. While the researchers don't envision movie stars on medicine bottles, they used Monroe's image to prove their concept.
Imagine you're fighting for your life but no matter how hard you hit, your opponent won't go down. The same can be said of highly treatment-resistant cancers, such as head and neck cancer, where during radiation and chemotherapy some cancer cells repair themselves, survive and thrive. Head and neck cancer is the sixth most common cancer in the world, but the late detection and treatment resistance result in a high mortality rate.
HIV-infected people carry many different HIV viruses and all have distinct personalities—some much more vengeful and infectious than others. Yet, despite the breadth of infectivity, roughly 76% of HIV infections arise from a single virus. Now, scientists believe they can identify the culprit with very specific measurements of the quantities of a key protein in the HIV virus.
Researchers have taken a major stride toward perfectly efficient lighting that is also relatively inexpensive and simple to make. The same material can also reveal the presence of water by changing color. Incandescent bulbs only turn 5% of the electricity they use into light, while fluorescent LEDs can produce light from up to 25% of the electrons that pass through them. Phosphorescent LEDs can turn every electron into a ray of light.
Biophysics researchers have used short pulses of light to peer into the mechanics of photosynthesis and illuminate the role that molecule vibrations play in the energy conversion process that powers life on our planet. The findings could potentially help engineers make more efficient solar cells and energy storage systems.
In work that unmasks some of the magic behind memristors and "resistive random access memory," or RRAM, researchers have shown that the metal particles in memristors don't stay put as previously thought. The findings have broad implications for the semiconductor industry and beyond. They show, for the first time, exactly how some memristors remember.
Researchers at the Univ. of Michigan have obtained the first 3-D snapshots of the "assembly line" within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.
Imaging and mapping of electric fields at radio frequencies (RF) currently requires the use of metallic structures such as dipoles, probes and reference antennas. To make such measurements efficiently, the size of these structures needs to be on the order of the wavelength of the RF fields to be mapped. This poses practical limitations on the smallest features that can be measured.
More Americans view global warming by what they see outside their windows and not scientific evidence, according to a Univ. of Michigan survey. While a majority of Americans still believe that global warming is occurring, the cold and snowy winter of 2014 created more disbelievers, according to the National Surveys on Energy and Environment.
Four major U.S. research universities have formed a technology consortium to improve the way in which educational content is shared across universities and ultimately delivered to students. Unizin will provide a common digital infrastructure that will allow member universities to work together to strengthen their traditional missions of education and research using the most innovative technology available today.
With precarious particles called polaritons that straddle the worlds of light and matter, Univ. of Michigan researchers have demonstrated a new, practical and potentially more efficient way to make a coherent laser-like beam. They have made what's believed to be the first polariton laser that is fueled by electrical current as opposed to light, and also works at room temperature, rather than way below zero.
Inspired by fictional cyborgs like Terminator, a team of researchers at the Univ. of Michigan and the Univ. of Pittsburgh has made the first bionic particles from semiconductors and proteins. These particles recreate the heart of the process that allows plants to turn sunlight into fuel.
When we're strolling down memory lane, our brains recall just as much information while walking as while standing still—findings that contradict the popular science notion that walking hinders one's ability to think. Univ. of Michigan researchers at the School of Kinesiology and the College of Engineering examined how well study participants performed a very complex spatial cognitive task while walking versus standing still.
Microbiologists have recently studied unseen armies of viruses and bacteria as they wage war at hydrothermal vents more than a mile beneath the ocean's surface. They have found that viruses infect bacterial cells to obtain tiny globules of elemental sulfur stored inside the bacterial cells. Instead of stealing this bounty, the viruses force the bacteria to burn their valuable sulfur reserves, then use the unleashed energy to replicate.
The ability to control crystals with light and chemistry could lead to chameleon-style color-changing camouflage for vehicle bodies and other surfaces. Univ. of Michigan researchers discovered a template-free method for growing shaped crystals that allows for changeable structures that could appear as different colors and patterns.
A 32-year study of subarctic forest moths in Finnish Lapland suggests that scientists may be underestimating the impacts of climate change on animals and plants because much of the harm is hidden from view. The study analyzed populations of 80 moth species and found that 90% of them were either stable or increasing throughout the study period, from 1978 to 2009.