Researchers report the first crystal structure of the cellular receptor CXCR4 bound to an immune signaling protein called a chemokine. The structure, published in Science, answers longstanding questions about a molecular interaction that plays an important role in human development, immune responses, cancer metastasis and HIV infections.
A team of researchers have demonstrated a way to emit and control quantum light generated using...
Small pieces of synthetic RNA trigger a RNA interference (RNAi) response that holds great...
Electrical engineers from the Univ. of California, San Diego have developed hardware for a new...
Biochemists in California have developed a program that predicts the placement of chemical marks that control the activity of genes based on sequences of DNA. By comparing sequences with and without epigenomic modification, the researchers identified DNA patterns associated with the changes. They call this novel analysis pipeline Epigram and have made both the program and the DNA motifs they identified openly available to other scientists.
Imagine being able to switch out the batteries in electric cars just like you switch out batteries in a photo camera or flashlight. Engineers in California are trying to accomplish just that, in partnership with a local San Diego engineering company. Rather than swapping out the whole battery, which is cumbersome and requires large, heavy equipment, engineers plan to swap out and recharge smaller units within the battery, known as modules.
Several types of radar-enabled early warning and pedestrian sensing systems have been developed by automotive OEMs, but Toyota Motor Corp. is the first to manufacture an Automotive Phased Array Radar (APAR) that satisfies the requirements for widespread use in vehicle safety system while also providing a wide 100-degree sensing arc capable of effectively detecting pedestrians.
A team of international researchers has discovered a new type of cool burning flames that could lead to cleaner, more efficient engines for cars. The discovery was made during a series of experiments on the International Space Station by a team led by Forman Williams, a professor of mechanical and aerospace engineering at the Univ. of California, San Diego.
Nanoengineers at UC San Diego have developed a nanoshell to protect foreign enzymes used to starve cancer cells as part of chemotherapy. Enzymes are naturally smart machines that are responsible for many complex functions and chemical reactions in biology. However, despite their huge potential, their use in medicine has been limited by the immune system, which is designed to attack foreign intruders.
An international team of scientists, led by researchers at the Univ. of California, San Diego School of Medicine, have identified the genes encoding a molecule that famously defines Group A Streptococcus (strep), a pathogenic bacterial species responsible for more than 700 million infections worldwide each year.
Computer scientists at Microsoft Research and the University of California, San Diego have developed a system, called ParentGuardian, that combines a mobile application and sensor to detect stress in parents. The system, initially tested on parents of children with ADHD, delivers research-based strategies to help decrease stress during emotionally charged interactions with children.
Computer scientists at the Univ. of California, San Diego have developed a tool that allows hardware designers and system builders to test security—a first for the field. There is a big push to create the so-called Internet of Things, where all devices are connected and communicate with one another. As a result, embedded systems—small computer systems built around microcontrollers—are becoming more common.
Taking a moment to pause and relax can help if you find yourself in a tight spot. This strategy can work for molecules as well as people, it turns out. Researchers at the Univ. of California, San Diego have found that DNA packs more easily into the tight confines of a virus when given a chance to relax.
Current approaches to flexible electronics, in which very thin semiconductor materials are applied to a thin, flexible substrate in wavy patterns and then applied to a deformable surface such as skin or fabric, are still built around hard composite materials that limit their elasticity. Researchers in California have made several discoveries, however, that could lead to electronics that are "molecularly stretchable."
Researchers in California have created, for the first time, compounds made from mixtures of calcium hexaboride, strontium and barium hexaboride. They also demonstrated that these ceramic materials could be manufactured using a simple, low-cost manufacturing method known as combustion synthesis.
Pharmaceutical researchers in California, in collaboration with materials scientists, engineers and neurobiologists, have discovered a new mechanism for using near-infrared light to activate polymeric drug-delivering nanoparticles and other targeted therapeutic substances inside the body. This discovery represents a major innovation; up to now only a handful of strategies using light-triggered release from nanoparticles have been reported.
Light can trigger coordinated, wave-like motions of atoms in atom-thin layers of crystal, scientists have shown. The waves, called phonon polaritons, are far shorter than light waves and can be "tuned" to particular frequencies and amplitudes by varying the number of layers of crystal, they report.
Researchers at the San Diego Supercomputer Center have developed software that greatly expands the types of multi-scale QM/MM (mixed quantum and molecular mechanical) simulations of complex chemical systems that scientists can use to design new drugs, better chemicals or improved enzymes for biofuels production.
Researchers in California have made progress in a project to develop fast-blinking light-emitting diode systems for underwater optical communications. They have shown that an artificial metamaterial can improve the “blink speed” of a fluorescent light-emitting dye molecule 76 times faster than normal while increasing brightness 80-fold.
Scientists at the Univ. of California, San Diego have developed a new genetic platform that allows efficient production of naturally occurring molecules, and have used it to produce a novel antibiotic compound. Their study, published in PNAS, may open new avenues for natural product discoveries and drug development.
With the help of biomimetic matrices, a research team led by bioengineers at the Univ. of California, San Diego has discovered exactly how calcium phosphate can coax stem cells to become bone-building cells. The team has traced a surprising pathway from these biomaterials to bone formation. Their findings will help them refine the design of biomaterials that encourage stem cells to give rise to new bone.
Researchers at Scripps Institution of Oceanography at the Univ. of California, San Diego have developed a method for greatly enhancing biofuel production in tiny marine algae. As reported online in the Proceedings of the National Academy of Sciences, Scripps graduate student Emily Trentacoste led the development of a method to genetically engineer a key growth component in biofuel production.
Officials at the University of California, San Diego announced that philanthropist T. Denny Sanford has committed $100 million to the creation of the Sanford Stem Cell Clinical Center. The center is intended to accelerate development of drugs and therapies derived from human stem cell research through clinical trials and patient therapies.
Cosmochemists at the Univ. of California, San Diego have solved a long-standing mystery in the formation of the solar system: Oxygen, the most abundant element in Earth’s crust, follows a strange, anomalous pattern in the oldest, most pristine rocks, one that must result from a different chemical process than the well-understood reactions that form minerals containing oxygen on Earth.
The San Diego Supercomputer Center at the Univ. of California, San Diego, has been awarded a grant from the National Science Foundation to build Comet, a new petascale supercomputer designed to transform advanced scientific computing by expanding access and capacity among research domains. Comet will be capable of an overall peak performance of nearly two petaflops, or two quadrillion operations per second.
Electron beam (e-beam) lithography enables researchers to write very small patterns on large substrates with a high level of precision. In the Nano3 cleanroom facility at the Univ. of California, San Diego’s Qualcomm Institute, a new Vistec e-beam writer is helping to develop nanoscale transistors for integrated electronics, as well as neural probes for brain diagnostics.
Scientists at the University of California, San Diego have designed tiny spherical particles to float easily through the bloodstream after injection, then assemble into a durable scaffold within diseased tissue. An enzyme produced by a specific type of tumor can trigger the transformation of the spheres into net-like structures that accumulate at the site of a cancer.
The tail of a seahorse can be compressed to about half its size before permanent damage occurs, engineers at the University of California, San Diego have found. The tail’s exceptional flexibility is due to its structure, made up of bony, armored plates, which slide past each other. Researchers are hoping to use a similar structure to create a flexible robotic arm equipped with muscles made out of polymer.
Engineers at the University of California, San Diego have invented a "nanosponge" capable of safely removing a broad class of dangerous toxins from the bloodstream. These nanosponges, which thus far have been studied in mice, can neutralize "pore-forming toxins," which destroy cells by poking holes in their cell membranes.
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