University of California, Los Angeles biochemists have mapped the structure of a key protein–RNA complex that is required for the assembly of telomerase, an enzyme important in both cancer and aging. The researchers found that a region at the end of the p65 protein that includes a flexible tail is responsible for bending telomerase's RNA backbone in order to create a scaffold for the assembly of other protein building blocks.
Researchers from Rice University and the University of California, Los Angeles unveiled a new data-encoding scheme that slashes more than 30% of the energy needed to write data onto new memory cards that use phase-change memory—a competitor to flash memory that has big backing from industry heavyweights.
By using a laser microbeam technology called optical tweezers, University of California, Irvine and University of California, Los Angeles researchers have uncovered fundamental properties of a key molecular signaling system involved with development, cancer, and cardiovascular disease.
In a new study, investigators from the University of California, Los Angeles describe how they synthesized polymers to attach to proteins in order to stabilize them during shipping, storage, and other activities. The study findings suggest that these polymers could be useful in stabilizing protein formulations.
The overwhelming majority of proteins and other functional molecules in our bodies display chirality: They can exist in two distinct forms that are mirror images of each other. Seeking out a reason for why biological systems express chiral preferences, researchers used lithography to make achiral triangles with no handedness. Then physical entropic forces took over and scientists were completely surprised.
Online crowd-sourcing—in which a task is presented to the public, who respond, for free, with various solutions and suggestions—has been used to evaluate potential consumer products, develop software algorithms, and solve vexing research and development challenges. But diagnosing infectious diseases?
University of California, Los Angeles researchers and their colleagues have developed a novel screening technology that allows large batches of metal-oxide nanomaterials to be assessed quickly, based on their ability to trigger certain biological responses in cells as a result of their semiconductor properties.
Researchers have taken advantage of cells' physical properties to develop a new instrument that slams cells against a wall of fluid and quickly analyzes the physical response, allowing for the identification of cancer and other cell states without expensive chemical tags.
A newly developed cell phone-based platform lets health workers accurately read diagnostic tests in the field and chart the spread of diseases worldwide.
New research by University of California, Los Angeles biologists could lead to predictions of which plant species will escape extinction from climate change. Droughts are worsening around the world, which poses a great challenge to plants in gardens and forests. Scientists have debated for more than a century how to predict which species are most vulnerable.
Researchers at New York University and the University of California, Los Angeles, developed a method to detect sequence difference in individual DNA molecules by taking nanoscopic pictures of molecules themselves. Using direct molecular recognition, the researchers used nanoparticles to turn DNA molecules into a form of molecular Braille that can be read in the scale of nanometers using an atomic force microscope.
University of California, Los Angeles researchers are now able to peer deep within the world's tiniest structures to create 3D images of individual atoms and their positions. Their research presents a new method for directly measuring the atomic structure of nanomaterials.
Researchers at the University of California, Los Angeles have used a standard LightScribe DVD optical drive to produce electrodes composed of an expanded network of graphene that shows excellent mechanical and electrical properties as well as exceptionally high surface area. These LSG supercapacitors demonstrate high-performance graphene-based electrochemical capacitors that maintain excellent electrochemical attributes under high mechanical stress.
Researchers from the University of California, Los Angeles have developed a new cell phone-based fluorescent imaging and sensing platform that can detect the presence of the bacterium Escherichia coli in food and water.
Researchers at University of California, Los Angeles report a unique way to enhance polymer solar cell performance by building a tandem structure device. The device's architecture has also proven to be widely applicable after the researchers adopted a new material provided by Sumitomo Chemical of Japan, increasing the power conversion efficiency from 8.62% to a new world record of 10.6%.
In a recent study, participants played a video game in which they learned the locations of stores in a virtual city. The study showed that they recalled the locations better also received a painless boost from tiny electrodes buried deep inside their brains. The finding may have uses in treating Alzheimer’s disease.
A team led by University of California, Los Angeles research astronomer Michael Rich has used a unique telescope to discover a previously unknown companion to the nearby galaxy NGC 4449, which is some 12.5 million light years from Earth. The newly discovered dwarf galaxy had escaped even the prying eyes of the Hubble Space Telescope.
University of California, Los Angeles researchers have explained the puzzling disappearing act of energetic electrons in Earth's outer radiation belt, using data collected from a fleet of orbiting spacecraft. In a paper, the team shows that the missing electrons are swept away from the planet by a tide of solar wind particles during periods of heightened solar activity.
Two women who are legally blind from two different incurable conditions appeared to gain some vision after receiving an experimental treatment using embryonic stem cells. Experts caution that discussion of clinical treatment is premature at this stage.
Minuscule amounts of ethanol, the type of alcohol found in alcoholic beverages, can more than double the life span of a tiny worm known as Caenorhabditis elegans , which is used frequently as a model in aging studies, University of California, Los Angeles biochemists report. The scientists said they find their discovery difficult to explain.
University of California, Los Angeles physicists have made nanomechanical measurements of unprecedented resolution on protein molecules. The new measurements are approximately 100 times higher in resolution than previous mechanical measurements, a nanotechnology feat which reveals an isolated protein molecule, surprisingly, is neither a solid nor a liquid.
Researchers from Aneeve Nanotechnologies, a start-up company at the University of California, Los Angeles' on-campus technology incubator at the California NanoSystems Institute, have used low-cost inkjet printing to fabricate the first circuits composed of fully printed back-gated and top-gated carbon nanotube–based electronics for use with OLED displays.
Researchers from University of California, Los Angeles' cancer and stem cell centers have demonstrated for the first time that blood stem cells can be engineered to create cancer-killing T-cells that seek out and attack a human melanoma. The researchers believe the approach could be useful in about 40% of Caucasians with this malignancy.
Using a new microwave instrument based on the same principles as police radar guns, researchers from University of California, Los Angeles have finally observed very rapid changes in plasma turbulence in the DIII-D tokamak. These changes, which create and destroy surface flow eddies, are responsible for most of the heat losses in tokamak plasmas.
Data from a clinical trial involving University of California, Los Angeles researchers suggest that a new therapy may potentially serve as a "functional cure" for HIV/AIDS. The therapy, called SB-728-T, involves the modification of both copies of a patient's CCR5 gene, which encodes the major co-receptor used by HIV to infect immune system cells.