A diverse team of scientists from Univ. of California, Los Angeles' Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.
Working on the cutting edge of a newly emerging area of solar-cell research, Univ. of California, Los Angeles engineers have invented a new process for manufacturing highly efficient photovoltaic materials that shows promise for low-cost industrial production. The new process uses so-called perovskite materials, which in the past few years have significantly advanced scientists' efforts to create the next generation of solar cells.
A team of engineers from the Univ. of California, Los Angeles has developed a smartphone attachment and application to test water for the presence of mercury, a toxic heavy metal. The new platform could significantly reduce the time and cost of the testing, and it could be particularly useful in regions with limited technological resources.
To safely use bacteria in agriculture to help fertilize crops, it is vital to understand the difference between harmful and healthy strains. The bacterial genus Burkholderia, for example, includes dangerous disease-causing pathogens—one species has even been listed as a potential bioterrorist agent—but also many species that are safe and important for plant development.
A new study by researchers at the Univ. of California, Los Angeles and McGill Univ. reveals that the U.S. health care system ranks 22nd out of 27 high-income nations when analyzed for its efficiency of turning dollars spent into extending lives. The study illuminates stark differences in countries' efficiency of spending on health care, and the U.S.'s inferior ranking reflects a high price paid and a low return on investment.
A team of researchers have demonstrated a technique that, by measuring the physical properties of individual cells in body fluids, can diagnose cancer with a high degree of accuracy. The technique, which uses a deformability cytometer to analyze individual cells, could reduce the need for more cumbersome diagnostic procedures and the associated costs, while improving accuracy over current methods.
Univ. of California, Los Angeles chemists, for the first time, have employed magnetic resonance imaging to better measure the temperature of gases inside a catalytic reactor. The research, a major step toward bridging the gap between laboratory studies and industrial catalysis, could help improve the design and environmental impact of catalytic reactors.
Everyone grows older, but scientists don't really understand why. Now a Univ. of California, Los Angeles study has uncovered a biological clock embedded in our genomes that may shed light on why our bodies age and how we can slow the process.
When the "war on cancer" was declared, identifying potential biomarkers that would allow doctors to detect the disease early on was a significant goal. To this day, progress depends on understanding the underlying causes and molecular mechanisms of the disease. In a new study, researchers analyzed the gene-expression profiles of more than 2,000 patients and were able to identify cancer-specific gene signatures for certain cancers.
Univ. of California, Los Angeles chemical engineering researchers have created a new synthetic metabolic pathway for breaking down glucose that could lead to a 50% increase in the production of biofuels. The new pathway is intended to replace the natural metabolic pathway known as glycolysis, a series of chemical reactions that nearly all organisms use to convert sugars into the molecular precursors that cells need.
Inspired by how wireless communication networks use multiple radio frequencies to communicate with multiple users, researchers from the Univ. of California, Los Angeles have developed a new high-speed microscopy technique that is an order of magnitude faster than current fluorescence-imaging technologies.
Imagine an electronic display nearly as clear as a window, or a curtain that illuminates a room, or a smartphone screen that doubles in size, stretching like rubber. Now imagine all of these being made from the same material. Researchers from Univ. of California, Los Angeles have developed a transparent, elastic OLED that could one day make all these possible.
Since the discovery of the Van Allen radiation belts in 1958, space scientists have believed these belts encircling the Earth consist of two doughnut-shaped rings of highly charged particles. In February of 2013, a team of scientists reported the surprising discovery of a previously unknown third radiation ring. In new research, scientists have successfully modeled and explained the unprecedented behavior of this third ring.
Your smartphone now can see what the naked eye cannot: A single virus and bits of material less than one-thousandth of the width of a human hair. A team at the Univ. of California, Los Angeles has created a portable smartphone attachment that can be used to perform sophisticated field testing to detect viruses and bacteria without the need for bulky and expensive microscopes and lab equipment. The device weighs less than half a pound.
A lightweight and field-portable device invented at Univ. of California, Los Angeles that conducts kidney tests and transmits data through a smartphone attachment may significantly reduce the need for frequent office visits by people with diabetes and others with chronic kidney ailments.
In collaboration with teams in China, researchers in California have used the technology of single-cell RNA sequencing to track the genetic development of a human and a mouse embryo at a high level of accuracy. The technique could lead to earlier and more accurate diagnoses of genetic diseases, even when the embryo consists of only eight cells.
A team of researchers at the Univ. of California, Los Angeles have designed a system to encrypt software so that it only allows someone to use a program as intended while preventing any deciphering of the code behind it. This is known in computer science as "software obfuscation," and it is the first time it has been accomplished.
The ultimate dream come true for material scientists is to have the ability to make materials that can take on properties and behaviors to best suit our needs. But scientists first must truly understand the properties of cluster assembly through the individual cluster. Now, material scientists will have greater insight into the organizing principles that allow for the design of nanoscopic materials with specific band gap energy.
The genetic malady known as Fragile X syndrome is the most common cause of inherited autism and intellectual disability. Brain scientists know the gene defect that causes the syndrome and understand the damage it does in misshaping the brain's synapses—the connections between neurons. But how this abnormal shaping of synapses translates into abnormal behavior is unclear. Now, researchers believe they know.
Bacteria on a surface wander around and often organize into highly resilient communities known as biofilms. It turns out that they organize in a rich-get-richer pattern similar to the distribution of wealth in the U.S. economy, according to a new study.
A research team led by UCLA bioengineers has developed a way to program and control the shape of fluids flowing through pipes or conduits without the need to solve complex and time-consuming fluid-motion equations. This strategy could allow researchers to tap the vast, unrealized potential of fluid-flow applications.
Leaving the house in the morning may seem simple, but with every move we make, our brains are working to create maps of the outside world that allow us to navigate and remember where we are. Ultimately, the brain constructs its own pinpoint geographical chart that is far more precise than anything you'd find on Google Maps. But just how neurons make these maps of space has fascinated scientists for decades. Until now.
Many collisions occur between asteroids and other objects in our solar system, but scientists are not always able to detect or track these impacts from Earth. Space scientists at the University of California, Los Angeles have now devised a way to monitor these types of collisions in interplanetary space by using a new method to determine the mass of magnetic clouds that result from the impacts.
Excess heat, like that generated by extended use of a computer or other device, naturally creates what is known as a spin wave that can move a domain wall, the dividing line between magnetic materials that point in different directions. Using this phenomenon, scientists in California have demonstrated how to add power to a spintronics device using electron spin rather than electron charge.
Doctors have begun to categorize breast cancers into four main groups according to the genetic makeup of the cancer cells. Which category a cancer falls into generally determines the best method of treatment. But cancers in one of the four groups—called "basal-like" or "triple-negative" breast cancer (TNBC)—have been particularly tricky to treat. Researchers have developed a potential treatment for TNBC that uses nanodiamonds.