Yeast can quickly adapt to changes in its environment with the help of molecules known as long non-coding RNAs, a Purdue Univ. study shows. The team of researchers found that long non-coding RNAs prepare metabolic genes to be activated swiftly when baker's yeast needs to switch its source of energy from glucose to an alternative sugar, galactose.
Purdue Univ. researchers have developed a laser sensor that can identify Salmonella bacteria grown from food samples about three times faster than conventional detection methods. Known as BARDOT, the machine scans bacteria colonies and generates a distinct black and white "fingerprint" by which they can be identified. BARDOT takes less than 24 hrs to pinpoint Salmonella.
Researchers have discovered a potential treatment for a viral infection that causes potentially fatal brain swelling and paralysis in children. The findings also point to possible treatments for related viruses including those that cause common cold symptoms. The virus, called enterovirus 71 (EV71), causes yearly outbreaks of hand, foot and mouth disease in Southeast Asian countries, including China and Malaysia.
Researchers are proposing a new technology that might control the flow of heat the way electronic devices control electrical current, an advance that could have applications in a diverse range of fields from electronics to textiles. The concept uses tiny triangular structures to control phonons, quantum-mechanical phenomena that describe how vibrations travel through a material's crystal structure.
Researchers have shown how to increase the efficiency of thin-film solar cells, a technology that could bring low-cost solar energy. The approach uses 3-D photonic crystals to absorb more sunlight than conventional thin-film cells. The synthetic crystals possess a structure called an inverse opal to make use of and enhance properties found in the gemstones to reflect, diffract and bend incoming sunlight.
Purdue Univ. researchers have discovered a microbial-like pathway in plants that produces phenylalanine. Plants mainly synthesize phenylalanine through a chain of chemical reactions that converts the organic acid arogenate to phenylalanine. But Purdue researchers demonstrated that plants also use an alternative pathway found in most microorganisms to make phenylalanine from phenylpyruvate.
Researchers at Purdue Univ. have successfully tested the conversion of large particles of pinewood char in a gasification process, a step necessary for the mass production of synthetic liquid fuel from recalcitrant biomass. The results stemmed from a series of experiments using a new facility at Purdue's Maurice J. Zucrow Laboratories aimed at learning precisely how biomass is broken down in reactors called gasifiers.
Researchers are developing computers capable of "approximate computing" to perform calculations good enough for certain tasks that don't require perfect accuracy, potentially doubling efficiency and reducing energy consumption. Purdue researchers have developed a range of hardware techniques to demonstrate approximate computing, showing a potential for improvements in energy efficiency.
Researchers have created a new type of molecular motor made of DNA and demonstrated its potential by using it to transport a nanoparticle along the length of a carbon nanotube. The design was inspired by natural biological motors that have evolved to perform specific tasks critical to the function of cells.
Scientists working to advance imaging useful to medicine and security are capitalizing on the same phenomenon behind the lingering "ghost" image that appeared on old television screens. A team of researchers has created a way to control the length of time light from a luminescent nanocrystal lingers, adding a new dimension of time to color and brightness in optical detection technology.
Researchers have determined the structure of the rubella virus capsid protein, which is central to the virus's ability to assemble into an infectious particle and to infect humans. Although a successful vaccine is available to protect against rubella virus infection, the discovery could aid efforts to develop vaccines and antiviral drugs to treat related infections.
Researchers have created tiny holograms using a metasurface capable of the ultra-efficient control of light, representing a potential new technology for advanced sensors, high-resolution displays and information processing. The metasurface, thousands of V-shaped nanoantennas formed into an ultra-thin gold foil, could make possible optical switches small enough to be integrated into computer chips for information processing.
Iris scans, fingerprint scans, facial and voice recognition are tools that improve security while making our lives easier, says Stephen Elliott, director of international biometric research at Purdue Univ. His basement lab is a place where emerging biometric technologies are tested for weaknesses before they can go mainstream.
Purdue Univ. researchers have successfully eliminated the native infection preferences of a Sindbis virus engineered to target and kill cancer cells, a milestone in the manipulation of this promising viral vector. The achievement also demonstrates the ability to use methods of manipulation previously only applied to proteins.
Researchers at Purdue Univ. have developed prototypes of a water disinfection system to take advantage of ultraviolet (UV) radiation from the sun, which is plentiful in many areas where clean water is lacking. Their water disinfection system pumps water through a UV-transparent pipe placed on a parabolic reflector, effectively magnifying the effect of UV radiation, which damages microorganism DNA.
Researchers at Purdue Univ. are developing a method to mass-produce a new type of nanomaterial for advanced sensors and batteries, with an eye toward manufacturing in the Midwest. Research findings indicate the material shows promise as a sensor for detecting glucose in the saliva or tears and for "supercapacitors" that could make possible fast-charging, high-performance batteries.
OnTarget Laboratories LLC has teamed with partners in academia to test a novel optical imaging technology developed at Purdue Univ. that could help surgeons see cancer tissue during surgery. The technology is based on the over-expression of specific receptors on solid cancerous tumors and enables illumination of the tumor tissue during surgery.
For the threat of meteor strikes large or small, early detection is key, and evacuation may be the only defense needed within the next 1,000 years, according to an asteroid impact expert. The best investment in asteroid defense is not in weapons to deflect them, but in telescopes and surveys to find them.
Researchers have developed a system that concentrates foodborne salmonella and other pathogens faster than conventional methods by using hollow thread-like fibers that filter out the cells. The machine, called a continuous cell concentration device, could make it possible to routinely analyze food or water samples to screen for pathogens within a single work shift at food processing plants.
Researchers are developing a system that uses tiny magnetic beads to quickly detect rare types of cancer cells circulating in a patient's blood, an advance that could help medical doctors diagnose cancer earlier than now possible and monitor how well a patient is responding to therapy.
Researchers at Purdue Univ. have shown how to reduce fuel consumption while improving the efficiency of hydraulic steering systems in heavy construction equipment. The new approach incorporates several innovations: It eliminates valves now needed to direct the flow of hydraulic fluid in steering systems and uses advanced algorithms and models to precisely control hydraulic pumps.
Purdue Univ. researchers are working with the U.S. Army Research Laboratory to develop a technology for creating parts out of interlocking segments produced using 3-D printing to repair vehicles and other equipment in the field. The Purdue portion of the research focuses on clever, Lego-like building blocks called "topologically interlocking structures”.
Researchers have taken detailed images and measurements of the morphing structure of a brain protein thought to play a role in Parkinson's disease, information that could aid the development of medications to treat the condition. The protein, called alpha synuclein, ordinarily exists in a globular shape. However, the protein morphs into amyloid fibrils, which are linked to protein molecules that form and cause neurodegenerative diseases.
Purdue Univ. researchers are peering into the future to help the U.S. foil enemy missile attacks. Working with the U.S. Missile Defense Agency, the research team is creating software that makes it possible to pose various "what-if" questions; scenarios that explore plausible future missile advances in adversarial nations and the defensive capability of the U.S.
A recent invention at Purdue Univ. could improve therapy selection for personalized cancer care. Researchers have created a technique called BioDynamic Imaging that measures the activity inside cancer biopsies, or samples of cells. It allows technicians to assess the efficacy of drug combinations, called regimens, on personal cancers.