Massachusetts Institute of Technology engineers have devised a way to rapidly test hundreds of different drug-delivery vehicles in living animals, making it easier to discover promising new ways to deliver a class of drugs called biologics, which includes antibodies, peptides, RNA and DNA, to human patients.
Years before they show any other signs of disease, pancreatic cancer patients have very high levels of certain amino acids in their bloodstream, according to a new study. This finding, which suggests that muscle tissue is broken down in the disease’s earliest stages, could offer new insights into developing early diagnostics for pancreatic cancer, which kills about 40,000 Americans every year.
The key to creating a material that would be ideal for converting solar energy to heat is tuning the material’s spectrum of absorption just right: It should absorb virtually all wavelengths of light that reach Earth’s surface from the sun—but not much of the rest of the spectrum, since that would increase the energy that is reradiated by the material, and thus lost to the conversion process.
Concrete can be better and more environmentally friendly by paying attention to its atomic structure, according to researchers at Rice Univ., the Massachusetts Institute of Technology and Marseille Univ. The international team of scientists has created computational models to help concrete manufacturers fine-tune mixes for general applications.
Massachusetts Institute of Technology researchers unveiled an oval-shaped submersible robot, a little smaller than a football, with a flattened panel on one side that can slide along an underwater surface to perform ultrasound scans. Originally designed to look for cracks in nuclear reactors’ water tanks, the robot could also inspect ships for the false hulls and propeller shafts that smugglers frequently use to hide contraband.
Bacillus anthracis bacteria have very efficient machinery for injecting toxic proteins into cells, leading to the potentially deadly infection known as anthrax. A team of Massachusetts Institute of Technology (MIT) researchers has now hijacked that delivery system for a different purpose: administering cancer drugs.
Donald Sadoway and his colleagues at the Massachusetts Institute of Technology have already started a company to produce electrical-grid-scale liquid batteries, whose layers of molten material automatically separate due to their differing densities. But a newly developed formula substitutes different metals for the molten layers. The new formula allows the battery to work at a much lower temperature.
Each year, new strains of bacteria emerge that resist even the most powerful antibiotics, but scientists have discovered very few new classes of antibiotics in the past decade. Engineers have now turned a powerful new weapon on these superbugs. Using a gene-editing system that can disable any target gene, they have shown that they can selectively kill bacteria carrying harmful genes that confer antibiotic resistance or cause disease.
Researchers at Massachusetts Institute of Technology (MIT) and Northeastern Univ. have equipped a robot with a novel tactile sensor that lets it grasp a USB cable draped freely over a hook and insert it into a USB port. The sensor is an adaptation of a technology called GelSight, which was developed at MIT, and first described in 2009.
For future astronauts, the process of suiting up may go something like this: Instead of climbing into a conventional, bulky, gas-pressurized suit, an astronaut may don a lightweight, stretchy garment, lined with tiny, muscle-like coils. She would then plug in to a spacecraft’s power supply, triggering the coils to contract and essentially shrink-wrap the garment around her body.
Chips that use light, rather than electricity, to move data would consume much less power. Of the three chief components of optical circuits—light emitters, modulators and detectors—emitters are the toughest to build. One promising light source for optical chips is molybdenum disulfide (MoS2), which has excellent optical properties when deposited as a single, atom-thick layer.
Cephalopods are among nature’s most skillful camouflage artists, able to change both the color and texture of their skin within seconds to blend into their surroundings. Engineers have long struggled to duplicate this in synthetic materials. Now a team of researchers has come closer than ever to achieving that goal, creating a flexible material that can change its color or fluorescence and its texture at the same time.
The fastest land animal on Earth, the cheetah, is able to accelerate to 60 mph in just a few seconds. As it ramps up to top speed, a cheetah pumps its legs in tandem, bounding until it reaches a full gallop. Now, researchers have developed an algorithm for bounding that they’ve successfully implemented in a fully functional robotic cheetah.
The central mystery of quantum mechanics is that small chunks of matter sometimes seem to behave like particles, sometimes like waves. For most of the past century, the prevailing explanation of this conundrum has been what’s called the “Copenhagen interpretation”—which holds that, in some sense, a single particle really is a wave, smeared out across the universe, that collapses into a determinate location only when observed.
The central mystery of quantum mechanics is that small chunks of matter sometimes seem to behave like particles, sometimes like waves. The traditional view holds that a single particle really is a wave that collapses only when observed. But John Bush, of the Massachusetts Institute of Technology, believes that another explanation, the pilot-wave theory, deserves a second look.
When moving through a conductive material in an electric field, electrons tend to follow the path of least resistance—which runs in the direction of that field. But now physicists have found an unexpectedly different behavior under very specialized conditions—one that might lead to new types of transistors and electronic circuits that could prove highly energy efficient.
When a segment of a major fault line goes quiet, it can mean one of two things: The “seismic gap” may simply be inactive, or the segment may be a source of potential earthquakes, quietly building tension over decades until an inevitable seismic release. Researchers from Massachusetts Institute of Technology and Turkey have found evidence for both types of behavior on different segments of the North Anatolian Fault.
Objects in space tend to spin—and spin in a way that’s totally different from the way they spin on earth. Understanding how objects are spinning, where their centers of mass are, and how their mass is distributed is crucial to any number of actual or potential space missions, from cleaning up debris in the geosynchronous orbit favored by communications satellites to landing a demolition crew on a comet.
Around the world, there’s more salty groundwater than fresh, drinkable groundwater. For example, 60% of India is underlain by salty water. Now an analysis by Massachusetts Institute of Technology researchers shows that a different desalination technology called electrodialysis, powered by solar panels, could provide enough clean, palatable drinking water to supply the needs of a typical village.
It’s one of the highest-profile cases of scientific fraud in memory: In 2005, South Korean researcher Woo-Suk Hwang and colleagues made international news by claiming that they had produced embryonic stem cells from a cloned human embryo using nuclear transfer. But within a year, the work had been debunked, soon followed by findings of fraud. South Korea put a moratorium on stem cell research funding.
Over the past several decades, malaria diagnosis has changed very little. After taking a blood sample from a patient, a technician smears the blood across a glass slide, stains it with a special dye and looks under a microscope for the Plasmodium parasite, which causes the disease. This approach gives an accurate count of how many parasites are in the blood, but is not ideal because there is potential for human error.
Most memories have some kind of emotion associated with them. A new study from Massachusetts Institute of Technology neuroscientists reveals the brain circuit that controls how memories become linked with positive or negative emotions. Furthermore, the researchers found that they could reverse the emotional association of specific memories by manipulating brain cells with optogenetics.
If ever there were a silver lining to global warming, it might be the prospect of milder winters. After all, it stands to reason that a warmer climate would generate less snow. But a new Massachusetts Institute of Technology study suggests that you shouldn’t put your shovels away just yet.
Researchers have devised a new way to separate cells by exposing them to sound waves as they flow through a tiny channel. Their device, about the size of a dime, could be used to detect the extremely rare tumor cells that circulate in cancer patients’ blood, helping doctors predict whether a tumor is going to spread.
MIT Lincoln Laboratory’s Airborne Sense and Avoid (ABSAA) Radar Panel is a stepped-notch antenna array that marks a substantial advance in the fabrication of wide-bandwidth radar systems for use aboard unmanned aerial systems (UAS). The panel provides high performance by incorporating multifunction radio-frequency integrated circuits using a commercially available, high-volume silicon germanium (SiGe) 0.13-μm foundry process.