Reporting on their study with lab-grown human cells, researchers at The Johns Hopkins Univ. and the Univ. of Maryland say that blocking a second blood vessel growth protein, along with one that is already well-known, could offer a new way to treat and prevent a blinding eye disease caused by diabetes.
Imaging tests like mammograms or CT scans can detect tumors, but figuring out whether a growth...
Scientists at Johns Hopkins Univ. have created a 3-D model of a complex protein machine, ORC,...
Applying lessons learned from autism to brain cancer, researchers at The Johns Hopkins Univ. have discovered why elevated levels of the protein NHE9 add to the lethality of the most common and aggressive form of brain cancer, glioblastoma. Their discovery suggests that drugs designed to target NHE9 could help to successfully fight the deadly disease.
By analyzing the light of hundreds of thousands of celestial objects, Johns Hopkins Univ. astronomers from the Sloan Digital Sky Survey (SDSS) have created a unique map of enigmatic molecules in our galaxy that are responsible for puzzling features in the light from stars. The map was unveiled Jan. 8 at the 225th meeting of the American Astronomical Society in Seattle.
For a skin cell to do its job, it must turn on a completely different set of genes than a liver cell—and keep genes it doesn’t need switched off. One way of turning off large groups of genes at once is to send them to “time-out” at the edge of the nucleus, where they are kept quiet. New research from Johns Hopkins sheds light on how DNA gets sent to the nucleus’ far edge, a process critical to controlling genes and determining cell fate.
Cities like Miami are all too familiar with hurricane-related power outages. But a Johns Hopkins Univ. analysis finds climate change will give other major metro areas a lot to worry about in the future. Johns Hopkins engineers created a computer model to predict the increasing vulnerability of power grids in major coastal cities during hurricanes.
New findings by a Johns Hopkins Univ.-led team reveal long unknown details about carbon deep beneath the Earth’s surface and suggest ways this subterranean carbon might have influenced the history of life on the planet. The team also developed a new, related theory about how diamonds form in the Earth’s mantle.
When studying extremely fast reactions in ultra-thin materials, two measurements are better than one. A new research tool invented by researchers at Lawrence Livermore National Laboratory (LLNL), Johns Hopkins Univ. and NIST captures information about both temperature and crystal structure during extremely fast reactions in thin-film materials.
Massive black holes spewing out radio frequency-emitting particles at near-light speed can block formation of new stars in aging galaxies, a study has found. The research provides crucial new evidence that it is these jets of radio frequency feedback streaming from mature galaxies’ central black holes that prevent hot free gas from cooling and collapsing into baby stars.
By focusing on large, star-forming galaxies in the universe, researchers at Johns Hopkins Univ. were able to measure its radiation leaks in an effort to better understand how the universe evolved as the first stars were formed. The team reports in a paper published online in Science that an indicator used for studying star-forming galaxies that leak radiation, is an effective measurement tool for other scientists to use.
Researchers at The Johns Hopkins Univ. report they have deciphered the inner workings of a protein called YiiP that prevents the lethal buildup of zinc inside bacteria. They say understanding YiiP's movements will help in the design of drugs aimed at modifying the behavior of ZnT proteins, eight human proteins that are similar to YiiP, which play important roles in hormone secretion and in signaling between neurons.
Johns Hopkins Univ. biochemists have figured out what is needed to activate and sustain the virus-fighting activity of an enzyme found in CD4+ T cells, the human immune cells infected by HIV. The discovery could launch a more effective strategy for preventing the spread of HIV in the body with drugs targeting this enzyme, they say.
Whether it's a mug full of fresh-brewed coffee, a cup of hot tea or a can of soda, consuming caffeine is the energy boost of choice for millions who want to wake up or stay up. Now, researchers at the Johns Hopkins Univ. have found another use for the popular stimulant: memory enhancer.
Researchers have identified a protein that causes loss of function in immune cells combating HIV. The scientists report in a paper appearing online in the Journal of Clinical Investigation that the protein, Sprouty-2, is a promising target for future HIV drug development, since disabling it could help restore the cells’ ability to combat the virus that causes AIDS.
Researchers at Johns Hopkins Univ. have succeeded in making flattened, football-shaped artificial particles that impersonate immune cells. These football-shaped particles seem to be better than the typical basketball-shaped particles at teaching immune cells to recognize and destroy cancer cells in mice.
When a beating heart slips into an irregular, life-threatening rhythm, the treatment is well known: deliver a burst of electric current from a pacemaker or defibrillator. But because the electricity itself can cause pain, tissue damage and other serious side-effects, a Johns Hopkins-led research team wants to use laboratory data and an intricate computer model replace these jolts with a kinder, gentler remedy: light.
Scientists in the new but fast-growing field of computational genomics are facing a dilemma. These researchers have begun to assemble the chemical blueprints of the DNA found in humans, animals, plants and microbes. But a flood of unassembled genetic data is being produced much faster than current computers can turn it into useful information, two scholars in the field are warning.
When a solar flare filled with charged particles erupts from the sun, its magnetic fields sometimes break a widely accepted rule of physics. The flux-freezing theorem dictates that the magnetic lines of force should flow away in lock-step with the particles, whole and unbroken. Instead, the lines sometimes break apart and quickly reconnect in a way that has mystified astrophysicists.
Surgical robots could make some types of surgery safer and more effective, but proving that the software controlling these machines works as intended is problematic. Researchers at Carnegie Mellon University and Johns Hopkins University have demonstrated that methods for reliably detecting software bugs and ultimately verifying software safety can be applied successfully to this breed of robot.
Sounding like something out of a comic book, superatoms are not only an enticing idea, but experiments have confirmed they exist. Scientists at Virginia Commonwealth University have collaborated with scientists from Johns Hopkins University to synthesize the first magnetic superatoms.
Engineers have recently developed a portable mapping system—carried in a backpack—that can be used to automatically create annotated physical maps of locations where GPS is not available, such as in underground areas and on ships. The system improves upon algorithms once developed for robots—which are not practical for all environments—and has a built-in allowance for normal human movement, like walking.
A new online database combining symptoms, family history and genetic sequencing information is speeding the search for diseases caused by a single rogue gene. As described in an article in the May issue of Human Mutation, the database, known as PhenoDB, enables any clinician to document cases of unusual genetic diseases for analysis by researchers at the Johns Hopkins University School of Medicine or the Baylor College of Medicine.
Researchers at Johns Hopkins University have devised a way to detect whether cells previously transplanted into a living animal are alive or dead, an innovation they say is likely to speed the development of cell replacement therapies for conditions such as liver failure and type 1 diabetes.
Researchers from the NIST Center for Nanoscale Science and Technology and Johns Hopkins University have developed a technique to reliably manipulate hundreds of individual micrometer-sized colloid particles to create crystals with controlled dimensions. The accomplishment is an important milestone for understanding how to direct and control the assembly of microscale and nanoscale objects for nanomanufacturing applications.
Johns Hopkins Medicine researchers have succeeded in teaching computers how to identify commonalities in DNA sequences known to regulate gene activity, and to then use those commonalities to predict other regulatory regions throughout the genome. The tool is expected to help scientists better understand disease risk and cell development.
Troponin I, found exclusively in heart muscle, is already used as the gold-standard marker in blood tests to diagnose heart attacks, but the new findings by Johns Hopkins University researchers reveal why and how the same protein is also altered in heart muscle malfunctions that lead to heart failure. Scientists have known of “out-of-tune” proteins for a while, but the precise origin had remained unclear.
Much like a sentry at a border crossing, the network of tiny blood vessels surrounding the brain only allows a few important molecules in or out. This is the blood-brain barrier, which shields the brain from potentially harmful substances. Researchers are hoping to better understand this little understood roadblock by creating an artificially engineered, or simulated, barrier.
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