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The Lead

Climate models disagree on why temperature “wiggles” occur

January 26, 2015 11:06 am | by Duke Univ. | News | Comments

A new study finds that most climate models likely underestimate the degree of decade-to-decade variability occurring in mean surface temperatures as Earth's atmosphere warms. The models also provide inconsistent explanations of why this variability occurs in the first place. These discrepancies may undermine the models' reliability for projecting the short-term pace as well as the extent of future warming, the study's authors warn.

First contracting human muscle grown in laboratory

January 14, 2015 8:28 am | by Ken Kingery, Duke Univ. | Videos | Comments

In a laboratory first, Duke Univ. researchers have grown human skeletal muscle that contracts...

Mercury from gold mines accumulates far downstream

January 9, 2015 8:00 am | by Ken Kingery, Duke Univ. | News | Comments

Researchers have determined that the health risks taken on by artisanal, small-scale gold miners...

Study pinpoints autism-linked protein for sculpting brain connections

January 7, 2015 8:00 am | by Karl Bates, Duke Univ. | News | Comments

Shortly after birth, human brains expand rapidly with the experience of an entirely new world....

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Predicting superbugs’ countermoves to new drugs

January 5, 2015 7:29 am | by Robin Ann Smith, Duke Univ. | News | Comments

With drug-resistant bacteria on the rise, even common infections that were easily controlled for decades are proving trickier to treat with standard antibiotics. New drugs are desperately needed, but so are ways to maximize the effective lifespan of these drugs. To accomplish that, Duke Univ. researchers used software they developed to predict a constantly evolving infectious bacterium's countermoves to one of these new drugs ahead of time.

New tracers can identify coal ash contamination in water

December 16, 2014 2:20 pm | by Tim Lucas, Duke Univ. | News | Comments

Duke Univ. scientists have developed new forensic tracers to identify coal ash contamination in water and distinguish it from contamination coming from other sources. Previous methods to identify coal ash contaminants in the environment were based solely on the contaminants’ chemical variations. The newly developed tracers provide additional forensic fingerprints that give regulators a more accurate and systematic tool.

Laser sniffs out toxic gases from afar

December 3, 2014 4:45 pm | by Robin Anne Smith, Duke Univ. | News | Comments

Scientists have developed a way to sniff out tiny amounts of toxic gases from up to one kilometer away. The new technology can discriminate one type of gas from another with greater specificity than most remote sensors and under normal atmospheric pressure, something that wasn’t thought possible before.

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Angiogenesis drug could provide treatment for TB

November 25, 2014 9:27 am | by Karl Bates, Duke Univ. | News | Comments

The body responds to tuberculosis infection by locking the bacterial offenders into tiny clusters of immune cells called granulomas, which are a hallmark of the disease. This containment strategy succeeds at first, but eventually the bacteria manage to break out of these intercellular jails and spread throughout the body.

Is copper prostate cancer’s Kryptonite?

October 15, 2014 7:41 am | by Duke Medicine News and Communications | News | Comments

Like discriminating thieves, prostate cancer tumors scavenge and hoard copper that is an essential element in the body. But such avarice may be a fatal weakness. Researchers at Duke Medicine have found a way to kill prostate cancer cells by delivering a trove of copper along with a drug that selectively destroys the diseased cells brimming with the mineral, leaving non-cancer cells healthy.

How to hide like an octopus

September 17, 2014 7:33 am | by David L. Chandler, MIT News Office | News | Comments

Cephalopods are among nature’s most skillful camouflage artists, able to change both the color and texture of their skin within seconds to blend into their surroundings. Engineers have long struggled to duplicate this in synthetic materials. Now a team of researchers has come closer than ever to achieving that goal, creating a flexible material that can change its color or fluorescence and its texture at the same time.

Surprising new role for calcium in sensing pain

September 2, 2014 7:53 am | by Karl Bates, Duke Univ. | News | Comments

When you accidentally touch a hot oven, you rapidly pull your hand away. Although scientists know the basic neural circuits involved in sensing and responding to such painful stimuli, they are still sorting out the molecular players. Duke Univ. researchers have made a surprising discovery about the role of a key molecule involved in pain in worms, and have built a structural model of the molecule.

Exporting coal to Asia could slash emissions

August 20, 2014 9:26 am | by Tim Lucas, Duke Univ. | News | Comments

Under the right scenario, exporting U.S. coal to power plants in South Korea could lead to a 21% drop in greenhouse gas emissions compared to burning the fossil fuel at plants in the U.S., according to a new Duke Univ.-led study. For the reduction to occur, U.S. plants would need to replace the exported coal with natural gas. And in South Korea, the imported coal must replace other coal as the power source.

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New brain-based marker of stress susceptibility

July 29, 2014 1:05 pm | by Karl Bates, Duke Univ. | News | Comments

Some people can handle stressful situations better than others, and it’s not all in their genes: Even identical twins show differences in how they respond. Researchers have identified a specific electrical pattern in the brains of genetically identical mice that predicts how well individual animals will fare in stressful situations. The findings may eventually help researchers prevent potential consequences of chronic stress.

New technologies fuel patient participation, data collection in research

July 10, 2014 9:06 am | by Duke Medicine News and Communications | News | Comments

The changing dynamic of health studies driven by “big data” research projects will empower patients to become active participants who provide real-time information such as symptoms, side effects and clinical outcomes, according to researchers at Duke Medicine. The analysislays out a new paradigm for health research, particularly comparative effectiveness studies that are designed to assess which therapies work best in clinical practice.

Protein could put antibiotic-resistant bugs in handcuffs

June 10, 2014 7:38 am | News | Comments

Staph infections that become resistant to multiple antibiotics don't happen because the bacteria themselves adapt to the drugs, but because of a kind of genetic parasite they carry called a plasmid that helps its host survive the antibiotics. Plasmids are rings of bare DNA containing a handful of genes that are essentially freeloaders, borrowing most of what they need to live from their bacterial host.

One and done: Antibiotic could provide single-dose option

June 5, 2014 8:20 am | by Duke Medicine News and Communications | News | Comments

In the battle against stubborn skin infections, including methicillin-resistant Staphylococcus aureus (MRSA), a new single-dose antibiotic is as effective as a twice-daily infusion given for up to 10 days, according to a large study led by Duke Medicine researchers. Researchers said the advantage of the new drug, oritavancin, is its potential to curtail what has been a key driver of antibiotic resistance.

Small mutation changes brain freeze to hot foot

May 8, 2014 3:50 pm | News | Comments

Ice cream lovers and hot tea drinkers with sensitive teeth could one day have a reason to celebrate a new finding from Duke Univ. researchers. The scientists have found a very small change in a single protein that turns a cold-sensitive receptor into one that senses heat.

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Lab-grown muscle heals itself after animal implantation

April 2, 2014 12:07 pm | News | Comments

Biomedical engineers have grown living skeletal muscle that looks a lot like the real thing. It contracts powerfully and rapidly, integrates into mice quickly, and for the first time, demonstrates the ability to heal itself both inside the laboratory and inside an animal.

Lessons offered by emerging carbon trading markets

March 21, 2014 10:31 am | News | Comments

Although markets for trading carbon emission credits to reduce greenhouse gas emissions have stalled in U.S. federal policy-making, carbon markets are emerging at the state level within the U.S. and around the world, teaching us more about what does and doesn't work.

Past HIV vaccine trials reveal new path to success

March 20, 2014 8:05 am | News | Comments

A multinational research team led by Duke Medicine scientists has identified a subclass of antibodies associated with an effective immune response to an HIV vaccine. The finding helps explain why a combination of two vaccines was able to show some effect, when one vaccine alone did not. The study also provides key insights that could aid development of new vaccines.

New lens design improves kidney stone treatment

March 18, 2014 10:53 am | by Ken Kingery, Duke Univ. | News | Comments

Duke Univ. engineers have devised a way to improve the efficiency of lithotripsy—the demolition of kidney stones using focused shock waves. After decades of research, all it took was cutting a groove near the perimeter of the shock wave-focusing lens and changing its curvature.

Acoustic cloaking device hides objects from sound

March 12, 2014 7:35 am | by Ken Kingery, Duke Univ. | News | Comments

Using little more than a few perforated sheets of plastic and a staggering amount of number crunching, Duke Univ. engineers have demonstrated the world’s first 3-D acoustic cloak. The new device reroutes sound waves to create the impression that both the cloak and anything beneath it are not there.

Chemical signaling simulates exercise in cartilage cells

January 15, 2014 10:48 am | News | Comments

Cartilage is notoriously difficult to repair or grow, but researchers at Duke Medicine have taken a step toward understanding how to regenerate the connective tissue. By adding a chemical to cartilage cells, the chemical signals spurred new cartilage growth, mimicking the effects of physical activity. The findings point to an ion channel called TRPV4 as a potential target for new therapies to treat osteoarthritis or even regrow cartilage.

Tricky protein may help HIV vaccine development

January 13, 2014 3:48 pm | News | Comments

Duke Univ. scientists have taken aim at what may be an Achilles' heel of the HIV virus. Combining expertise in biochemistry, immunology and advanced computation, researchers at Duke have determined the structure of a key part of the HIV envelope protein, the gp41 membrane proximal external region (MPER), which previously eluded detailed structural description.

Superlens extends range of wireless power transfer

January 13, 2014 7:47 am | News | Comments

Inventor Nikola Tesla imagined the technology to transmit energy through thin air almost a century ago, but experimental attempts at the feat have so far resulted in cumbersome devices that only work over very small distances. But now, Duke Univ. researchers have demonstrated the feasibility of wireless power transfer using low-frequency magnetic fields over distances much larger than the size of the transmitter and receiver.

Acid mine drainage reduces radioactivity in fracking waste

January 9, 2014 11:34 am | News | Comments

Much of the naturally occurring radioactivity in fracking wastewater might be removed by blending it with another wastewater from acid mine drainage, according to a Duke Univ.-led study. Blending fracking wastewater with acid mine drainage also could help reduce the depletion of local freshwater resources by giving drillers a source of usable recycled water for the hydraulic fracturing process.

Supercomputers join search for “cheapium”

January 6, 2014 7:48 am | News | Comments

In the search for cheaper materials that mimic their purer, more expensive counterparts, researchers are abandoning hunches and intuition for theoretical models and pure computing power. In a new study, researchers from Duke Univ.’s Pratt School of Engineering used computational methods to identify dozens of platinum-group alloys that were previously unknown to science but could prove beneficial in a wide range of applications.

Engineers make strides toward artificial cartilage

December 13, 2013 1:50 pm | News | Comments

A Duke Univ. research team has developed a better recipe for synthetic replacement cartilage in joints. Combining two innovative technologies, the team found a way to create artificial replacement tissue that mimics both the strength and suppleness of native cartilage. Articular cartilage is the tissue on the ends of bones where they meet at joints in the body.

Copper promises cheaper, sturdier fuel cells

November 22, 2013 11:01 am | News | Comments

Converting solar energy into storable fuel remains one of the greatest challenges of modern chemistry. Chemists have commonly tried to use indium tin oxide (ITO) because it has transparency, but it also expensive and rare. Researchers at Duke Univ. has created something they hope can replace ITO: copper nanowires fused in a see-through film.

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