Nanomedicine

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Study: Quantum dots appear safe in pioneering study on primates

A year-long evaluation of the effect of quantum dots in primates has found the nanoparticles to be safe, encouraging doctors and scientists who are hoping to use them to battle diseases like cancer. Cadmium selenide quantum dots were the variety used in the study.

Nanoparticle shape may be key for delivery to cancer cells

Scientists had originally thought they could create a “magic bullet” to patrol for cancer cells in the body, but only 5% of injected nanoparticles reach the targeted tumor using current delivery techniques. A Johns Hopkins University scientist is now working on techniques to specify nanoparticle size and shape and improve the chances that the drug will find its target.

Neurotransmission is controlled by a single protein

Scientists at Weill Cornell Medical College have discovered that the single protein, alpha 2 delta, exerts a spigot-like function that controls the volume of neurotransmitters and other chemicals that flow between the synapses of brain neurons. The surprising finding tells us not only how brain cells communicate, but also how a certain pain drug works.

Team discovers new way to stimulate immune cells

A research team at Rutgers University has been able to take a new pharmacological approach to activate the immune cells to prevent cancer growth through stimulation of the opiate receptors found on immune cells.

Target: Drug-resistant bacteria

Target: Drug-resistant bacteria

Over the past several decades, scientists have faced challenges in developing new antibiotics even as bacteria have become increasingly resistant to existing drugs. One strategy that might combat such resistance would be to overwhelm bacterial defenses by using highly targeted nanoparticles to deliver large doses of existing antibiotics. In a step toward that goal, researchers have developed a nanoparticle designed to evade the immune system and home in on infection sites, then unleash a focused antibiotic attack.

New form of spectroscopy tracks differentiating cells in real time

New form of spectroscopy tracks differentiating cells in real time

With the development of synchrotron infrared spectroscopy, scientists at Lawrence Berkeley National Laboratory have observed, in real time the process of protein phosphorylation—a chemical interaction that controls everything from cell proliferation to differentiation to metabolism—in living cells stimulated by nerve growth factor.

Magnetoelectric sensors designed for medical measurement

Magnetoelectric sensors designed for medical measurement

Until the development of a new nanomaterial-based sensor in Germany, the brain’s magnetic field was measurable only under technical laboratory conditions. This prevented the technology’s use in medical applications. The new sensors, however, operate at normal conditions. Neither cooling nor external magnetic bias fields are required.

New X-ray bionanoprobe enables study of cryogenically preserved samples

Researchers at Northwestern University's Department of Radiation Oncology and Argonne National Laboratory recently deployed a new non-destructive X-ray microscopy solution from Xradia to image cryogenically preserved cells and advance studies of intra-cellular biology.

Technique may help severely damaged nerves regrow and restore function

Engineers at the University of Sheffield have developed a method of making medical devices called nerve guidance conduits. Based on laser direct writing, which enables the fabrication of complex structures from computer files via the use of CAD/CAM, the polymer-based material will assist nerves damaged by traumatic accidents to repair naturally.

Tumor study reveals size limitations for new drugs

Tumor study reveals size limitations for new drugs

Combining two strategies that are designed to improve the results of cancer treatment—angiogenesis inhibitors and nanomedicines—may only be successful if the smallest nanomedicines are used. A new study by researchers at Harvard University and Massachusetts General Hospital has found that normalizing blood vessels within tumors can actually block the delivery of larger nanotherapy molecules.

Blogs

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R&D 100: Now and Then

R&D 100: Now and Then

As R&D Magazine prepares for the 50th annual R&D 100 Awards, the editors take a stroll through the awards history, and invite former winners to join them.

R&D 100 Awards: Final Deadline is April 30

R&D 100 Awards: Final Deadline is April 30

The editors of R&D Magazine have extended the submission deadline for the 2012 R&D 100 Awards to April 30, 2012, at 11:59 pm, eastern U.S. time. This is the FINAL DEADLINE. We cannot accept entries after that time.

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CC Radio - Episode 99

NIH bikes to work. For transcripts of this and other NIH Clinical Center podcasts, visit http://www.cc.nih.gov/podcast/

Blueshift - May 21, 2012: Astrophysicist to the Stars, Dr. David Saltzberg

In a follow-up to our previous interviews with co-creator of "The Big Bang Theory," Bill Prady, we interviewed Dr. David Saltzberg, the show's resident astrophysicist and science consultant. Find out more about his research, adventures in astrophysics, and how he keeps the science of the...

New To Market

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JEOL to launch world's smallest solid-state NMR probe
JEOL to launch world's smallest solid-state NMR probe

According to JEOL Resonance, a new benchmark for resolution and benchmark will be set with its introduction next week of a new 0.75-mm solid state nuclear magnetic resonance (NMR) probe. The probe is capable of high resolution sample analysis by spinning the sample at 110 kHz, the world's fastest spinning speed for NMR.

Energy Harvesting Subsystems for Wireless Sensors

Nextreme Thermal Solutions has developed two new energy harvesting subsystems for the plumbing and HVAC industries. The subsystems are the latest additions to Nextreme's Thermobility energy harvesting platform that uses thin-film thermoelectric technology to convert available thermal energy into electric power for a variety of autonomous self-powered applications.

Tools & Technology

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Microscope System with LED Illumination
Microscope System with LED Illumination

Leica Microsystems has introduced the Leica DM4000 B LED, a microscope system with LED illumination suited for biomedical applications.

Liquid Handler

Gilson Inc. has introduced the GX-241 liquid handler, a compact liquid handler suited for application and laboratories where bench space is at a premium.

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