Gene Therapy

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Gene activation follows a circuitous route

Gene activation follows a circuitous route

In order to reactivate silenced genes, a cell needs to remove certain “off” markers called methyl groups from the DNA. Scientists have recently shown that this process involves an intermediate step and an enzyme that also plays a role in the development of blood cancer. The finding could lead to new ideas for cancer-fighting therapies.

Spiral proteins could hasten arrival of gene therapy

Spiral proteins could hasten arrival of gene therapy

A group of University of Illinois researchers have demonstrated that short spiral-shaped proteins can efficiently deliver DNA segments to cells. The breakthrough was revisiting a known class of polypeptides and changing modifying their globular shape.

Gene therapy boosts blood-clotting for hemophiliacs

In what's being called a landmark study, researchers used gene therapy to successfully treat six patients with severe hemophilia, a blood-clotting disorder. The six men each received a single, 20-minute infusion of healthy genetic material delivered by a virus found in monkeys. Four of the patients were able to stop conventional blood-clotting treatments altogether.

Nanoparticle mimics virus, offers new route to gene therapy

Nanoparticle mimics virus, offers new route to gene therapy

Researchers at Yale University have deisgned a new nanoparticle that acts like a virus by introducing a specific gene into diseased cells in order to kill or repair them. The innovation has a number of promising applications in gene therapy.

Researchers perform precise gene therapy without a needle

For the first time, researchers have found a way to inject a precise dose of a gene therapy agent directly into a single living cell without a needle. The technique uses electricity to “shoot” bits of therapeutic biomolecules through a tiny channel and into a cell in a fraction of a second.

Gene therapy wipes out leukemia in study

Gene therapy wipes out leukemia in study

Scientists are reporting the first clear success with a new approach for treating leukemia. The breakthrough involves turning the patients' own blood cells into assassins that hunt and destroy their cancer cells.

Rush for patents is choking U.S. stem cell research

Rush for patents is choking U.S. stem cell research

Cures for paralysis, blindness and diabetes could all be in reach with embryonic stem cell research, but the pursuit of medical progress is being choked by the U.S. rush to secure patents, experts say.

Personal look at genes locates disease causes

Personal look at genes locates disease causes

Children inherit about 30 mutated genes from each parent, fewer than had been thought, but enough in at least one case to pass on inherited illnesses, according to a first detailed look at the blueprint for human life in a family. Genomic analysis is proving useful for diagnosing the origins of sometimes mysterious diseases.

DNA molecules in moss open door to new biotechnology

Plasmids, which are DNA molecules capable of independent replication in cells, have played an important role in gene technology. Researchers from Uppsala Univ. in Sweden have now demonstrated that plasmid-based methods, which had been limited to single-cell organisms such as bacteria and yeasts, can be extended to mosses, opening the door to applications of a number of powerful techniques in plant research.

Gene patch rebuilds out-of-body lungs

Gene patch rebuilds out-of-body lungs

It's something like a genetic Band-Aid: Canadian researchers took donated lungs deemed too damaged to transplant and repaired them with outside-the-body gene therapy. It will take lots more research to see if the fix lasts, to find out if the lungs work as well back inside a body as they do inside a see-through life-support dome in the laboratory. But the study published Wednesday has lung specialists hopeful they can boost the number of lungs available for people desperately in need.

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R&D 100: Now and Then

R&D 100: Now and Then

As R&D Magazine prepares for the 50th annual R&D 100 Awards, the editors take a stroll through the awards history, and invite former winners to join them.

R&D 100 Awards: Final Deadline is April 30

R&D 100 Awards: Final Deadline is April 30

The editors of R&D Magazine have extended the submission deadline for the 2012 R&D 100 Awards to April 30, 2012, at 11:59 pm, eastern U.S. time. This is the FINAL DEADLINE. We cannot accept entries after that time.

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CC Radio - Episode 99

NIH bikes to work. For transcripts of this and other NIH Clinical Center podcasts, visit http://www.cc.nih.gov/podcast/

Blueshift - May 21, 2012: Astrophysicist to the Stars, Dr. David Saltzberg

In a follow-up to our previous interviews with co-creator of "The Big Bang Theory," Bill Prady, we interviewed Dr. David Saltzberg, the show's resident astrophysicist and science consultant. Find out more about his research, adventures in astrophysics, and how he keeps the science of the...

New To Market

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JEOL to launch world's smallest solid-state NMR probe
JEOL to launch world's smallest solid-state NMR probe

According to JEOL Resonance, a new benchmark for resolution and benchmark will be set with its introduction next week of a new 0.75-mm solid state nuclear magnetic resonance (NMR) probe. The probe is capable of high resolution sample analysis by spinning the sample at 110 kHz, the world's fastest spinning speed for NMR.

Energy Harvesting Subsystems for Wireless Sensors

Nextreme Thermal Solutions has developed two new energy harvesting subsystems for the plumbing and HVAC industries. The subsystems are the latest additions to Nextreme's Thermobility energy harvesting platform that uses thin-film thermoelectric technology to convert available thermal energy into electric power for a variety of autonomous self-powered applications.

Tools & Technology

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Microscope System with LED Illumination
Microscope System with LED Illumination

Leica Microsystems has introduced the Leica DM4000 B LED, a microscope system with LED illumination suited for biomedical applications.

Liquid Handler

Gilson Inc. has introduced the GX-241 liquid handler, a compact liquid handler suited for application and laboratories where bench space is at a premium.

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