Drug Delivery
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May 24 | News
Getting a shot at the doctor's office may become less painful in the not-too-distant future. Massachusetts Institute of Technology researchers have engineered a device that delivers a tiny, high-pressure jet of medicine through the skin without the use of a hypodermic needle. The device can be programmed to deliver a range of doses to various depths—an improvement over similar jet-injection systems that are now commercially available.
May 18 | News
Scientists
had originally thought they could create a “magic bullet” to patrol for
cancer cells in the body, but only 5% of injected nanoparticles reach
the targeted tumor using current delivery techniques. A Johns Hopkins
University scientist is now working on techniques to specify
nanoparticle size and shape and improve the chances that the drug will
find its target.
May 15 | News
Scientists
at Weill Cornell Medical College have discovered that the single
protein, alpha 2 delta, exerts a spigot-like function that controls the
volume of neurotransmitters and other chemicals that flow between the
synapses of brain neurons. The surprising finding tells us not only how
brain cells communicate, but also how a certain pain drug works.
May 11 | News
Doctors have long known that treating patients with multiple cancer drugs often produces better results than treatment with just a single drug. Now, a study from Massachusetts Institute of Technology shows that the order and timing of drug administration can have a dramatic effect.
May 4 | News
Over the past several decades, scientists have faced challenges in developing new antibiotics even as bacteria have become increasingly resistant to existing drugs. One strategy that might combat such resistance would be to overwhelm bacterial defenses by using highly targeted nanoparticles to deliver large doses of existing antibiotics. In a step toward that goal, researchers have developed a nanoparticle designed to evade the immune system and home in on infection sites, then unleash a focused antibiotic attack.
May 3 | News
Researchers from Massachusetts Institute of Technology and Arizona State University are studying the mechanics of shape-shifting hydrogels: Looking for relationships between a hydrogel structure's initial shape, and the medium in which it transforms, in order to predict its final shape. The researchers report that they can now create and predict complex shapes from hydrogels.
Apr 26 | News
A
research team at Karolinska Institutet in Sweden has solved the puzzle
of the skin barrier: They have succeeded in describing the structure and
function of the outermost layer of the skin—the stratum corneum—at a
molecular level. This could enable large-scale delivery of drugs through
the skin, or offer a deeper understanding of skin diseases.
Apr 23 | News
While
microemulsions are now used for drug delivery, such as antibiotics and
syrups, using them for vaccines is new area of research. A U.S. Army
major has developed a microemulsion made from five ingredients that
could be a stable, promising candidate delivering a variety of antigens
against diseases such as influenza.
Apr 10 | News
Combining two strategies that are designed to improve the results of cancer treatment—angiogenesis inhibitors and nanomedicines—may only be successful if the smallest nanomedicines are used. A new study by researchers at Harvard University and Massachusetts General Hospital has found that normalizing blood vessels within tumors can actually block the delivery of larger nanotherapy molecules.
Apr 9 | News
Using light-harvesting nanoparticles to convert laser energy into plasmonic nanobubbles, researchers at Rice University, the University of Texas MD Anderson Cancer Center, and Baylor College of Medicine are developing new methods to inject drugs and genetic payloads directly into cancer cells. In tests on drug-resistant cancer cells, the researchers found that delivering chemotherapy drugs with nanobubbles was up to 30 times more deadly to cancer cells than traditional drug treatment.
