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Nanoparticle shape may be key for delivery to cancer cells

Scientists had originally thought they could create a “magic bullet” to patrol for cancer cells in the body, but only 5% of injected nanoparticles reach the targeted tumor using current delivery techniques. A Johns Hopkins University scientist is now working on techniques to specify nanoparticle size and shape and improve the chances that the drug will find its target.

One-two punch knocks out aggressive breast cancer cells

Doctors have long known that treating patients with multiple cancer drugs often produces better results than treatment with just a single drug. Now, a study from Massachusetts Institute of Technology shows that the order and timing of drug administration can have a dramatic effect.

Gene activation follows a circuitous route

Gene activation follows a circuitous route

In order to reactivate silenced genes, a cell needs to remove certain “off” markers called methyl groups from the DNA. Scientists have recently shown that this process involves an intermediate step and an enzyme that also plays a role in the development of blood cancer. The finding could lead to new ideas for cancer-fighting therapies.

Sunscreen ingredient may pose skin cancer risk

As vacationers prepare to spend time outdoors this summer, many of them will pack plenty of sunscreen in hopes it will protect their bodies from overexposure, and possibly from skin cancer. But researchers at Missouri University of Science and Technology are discovering that sunscreen may not be so safe after all.

Engineers put the squeeze on cells to diagnose disease

Engineers put the squeeze on cells to diagnose disease

Researchers have taken advantage of cells' physical properties to develop a new instrument that slams cells against a wall of fluid and quickly analyzes the physical response, allowing for the identification of cancer and other cell states without expensive chemical tags.

Scientists identify major source of cells' defense against oxidative stress

Both radiation and many forms of chemotherapy try to kill tumors by causing oxidative stress in cancer cells. New research from the University of Southern California on a protein that protects cancer and other cells from these stresses could one day help doctors to break down cancer cells' defenses, making them more susceptible to treatment.

'Nanobubbles' plus chemotherapy equals single-cell cancer targeting

Using light-harvesting nanoparticles to convert laser energy into plasmonic nanobubbles, researchers at Rice University, the University of Texas MD Anderson Cancer Center, and Baylor College of Medicine are developing new methods to inject drugs and genetic payloads directly into cancer cells. In tests on drug-resistant cancer cells, the researchers found that delivering chemotherapy drugs with nanobubbles was up to 30 times more deadly to cancer cells than traditional drug treatment.

Tiny 'factories' churn out proteins

Tiny 'factories' churn out proteins

Drugs made of protein have shown promise in treating cancer, but they are difficult to deliver because the body usually breaks down proteins before they reach their destination. To get around that obstacle, a team of Massachusetts Institute of Technology researchers has developed a new type of nanoparticle that can synthesize proteins on demand.

Tiny hitchhikers attack cancer cells

Nanotechnology offers powerful new possibilities for targeted cancer therapies, but the design challenges are many. Northwestern University scientists now are the first to develop a simple but specialized nanoparticle that can deliver a drug directly to a cancer cell's nucleus—an important feature for effective treatment.

Targeted nanoparticles show success in clinical trials

Targeted nanoparticles show success in clinical trials

Targeted therapeutic nanoparticles that accumulate in tumors while bypassing healthy cells have shown promising results in an ongoing clinical trial, according to a new paper. The nanoparticles feature a homing molecule that allows them to specifically attach cancer cells, and are the first such target particles to enter human clinical studies.

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R&D 100: Now and Then

R&D 100: Now and Then

As R&D Magazine prepares for the 50th annual R&D 100 Awards, the editors take a stroll through the awards history, and invite former winners to join them.

R&D 100 Awards: Final Deadline is April 30

R&D 100 Awards: Final Deadline is April 30

The editors of R&D Magazine have extended the submission deadline for the 2012 R&D 100 Awards to April 30, 2012, at 11:59 pm, eastern U.S. time. This is the FINAL DEADLINE. We cannot accept entries after that time.

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CC Radio - Episode 99

NIH bikes to work. For transcripts of this and other NIH Clinical Center podcasts, visit http://www.cc.nih.gov/podcast/

Blueshift - May 21, 2012: Astrophysicist to the Stars, Dr. David Saltzberg

In a follow-up to our previous interviews with co-creator of "The Big Bang Theory," Bill Prady, we interviewed Dr. David Saltzberg, the show's resident astrophysicist and science consultant. Find out more about his research, adventures in astrophysics, and how he keeps the science of the...

New To Market

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JEOL to launch world's smallest solid-state NMR probe
JEOL to launch world's smallest solid-state NMR probe

According to JEOL Resonance, a new benchmark for resolution and benchmark will be set with its introduction next week of a new 0.75-mm solid state nuclear magnetic resonance (NMR) probe. The probe is capable of high resolution sample analysis by spinning the sample at 110 kHz, the world's fastest spinning speed for NMR.

Energy Harvesting Subsystems for Wireless Sensors

Nextreme Thermal Solutions has developed two new energy harvesting subsystems for the plumbing and HVAC industries. The subsystems are the latest additions to Nextreme's Thermobility energy harvesting platform that uses thin-film thermoelectric technology to convert available thermal energy into electric power for a variety of autonomous self-powered applications.

Tools & Technology

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Microscope System with LED Illumination
Microscope System with LED Illumination

Leica Microsystems has introduced the Leica DM4000 B LED, a microscope system with LED illumination suited for biomedical applications.

Liquid Handler

Gilson Inc. has introduced the GX-241 liquid handler, a compact liquid handler suited for application and laboratories where bench space is at a premium.

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