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Raman nanoparticle-aided imaging of tumors moves closer to human trials

In 2008, Stanford researchers demonstrated the use of nanoparticle-aided Raman spectroscopy to look at microscopic structures, including nascent tumors, deep inside the body. That team has now conducted extensive preclinical tests and shown that the gold nanoparticles can be safely administered into the colon and used with a Raman endoscope to image the inside of the large intestines.

Mapping cells with submicrometer resolution

Mapping cells with submicrometer resolution

In an effort to identify cancer earlier on, researchers at NIST and the National Cancer Institute have developed a technique that slices off the top of a cell and makes the structures accessible to spectroscopic examination of their chemical "signature."

Whole living cells are flash-frozen and studied with new microscope

Whole living cells are flash-frozen and studied with new microscope

A new form of x-ray microscopy pioneered by researchers at the National Cancer Institute and the Helmholtz Association in Germany can take images of small cellular components in their natural environment, all while the cell remains completely intact. There is no need to chemically fix, stain, or cut the cells.

Proposed federal R&D funding dips for 2011

Reflecting the fortunes of a struggling economy, government R&D funding for 2011 is expected to slip about three-tenths of one percent from 2010 levels. The big news from the proposed package, however, is a marked fall in defense R&D: 6.6%. As a result, non-defense R&D could rise by several percentage points.

Flasks, beakers, and hot plates see new challenger

Lab-on-a-chip technology is nothing new, but performing 1,000 chemical reactions at once on a single chip the size of a fingernail is an accomplishment that just put microfluidics near the top of the toolkits for drug discovery efforts, as well as other chemical reaction evaluations. The reaction method is in situ click chemistry, in which potential drug molecules bind to protein enzymes that are then analyzed with mass spectrometry.

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R&D 100: Now and Then

R&D 100: Now and Then

As R&D Magazine prepares for the 50th annual R&D 100 Awards, the editors take a stroll through the awards history, and invite former winners to join them.

R&D 100 Awards: Final Deadline is April 30

R&D 100 Awards: Final Deadline is April 30

The editors of R&D Magazine have extended the submission deadline for the 2012 R&D 100 Awards to April 30, 2012, at 11:59 pm, eastern U.S. time. This is the FINAL DEADLINE. We cannot accept entries after that time.

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CC Radio - Episode 99

NIH bikes to work. For transcripts of this and other NIH Clinical Center podcasts, visit http://www.cc.nih.gov/podcast/

Blueshift - May 21, 2012: Astrophysicist to the Stars, Dr. David Saltzberg

In a follow-up to our previous interviews with co-creator of "The Big Bang Theory," Bill Prady, we interviewed Dr. David Saltzberg, the show's resident astrophysicist and science consultant. Find out more about his research, adventures in astrophysics, and how he keeps the science of the...

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JEOL to launch world's smallest solid-state NMR probe
JEOL to launch world's smallest solid-state NMR probe

According to JEOL Resonance, a new benchmark for resolution and benchmark will be set with its introduction next week of a new 0.75-mm solid state nuclear magnetic resonance (NMR) probe. The probe is capable of high resolution sample analysis by spinning the sample at 110 kHz, the world's fastest spinning speed for NMR.

Energy Harvesting Subsystems for Wireless Sensors

Nextreme Thermal Solutions has developed two new energy harvesting subsystems for the plumbing and HVAC industries. The subsystems are the latest additions to Nextreme's Thermobility energy harvesting platform that uses thin-film thermoelectric technology to convert available thermal energy into electric power for a variety of autonomous self-powered applications.

Tools & Technology

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Microscope System with LED Illumination
Microscope System with LED Illumination

Leica Microsystems has introduced the Leica DM4000 B LED, a microscope system with LED illumination suited for biomedical applications.

Liquid Handler

Gilson Inc. has introduced the GX-241 liquid handler, a compact liquid handler suited for application and laboratories where bench space is at a premium.

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