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1H NMR spectra of L-Histidine Hydrochloride |
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JEOL
Resonance, Inc., headquartered in Akishima, Tokyo, is scheduled to
announce a new 0.75 mm solid state NMR probe at the 53rd Experimental
Nuclear Magnetic Resonance Conference that opens on April 15, 2012 in
Miami, Florida.
The
probe is capable of high resolution sample analysis by spinning the
sample at 110 kHz, the world's fastest spinning speed for NMR.
The
new probe is expected to be effective in applications that are
difficult for conventional NMR systems, including micro analysis of
drugs, natural products, and thin films.
The
unprecedented spinning speed enables high resolution 1H analysis that
is not available at lower speeds, according to JEOL. This capability
will allow the researcher to identify different molecular ratios, total
structures in organic materials and aids in the structural analysis of
proteins. Additionally it will allow for high precision analysis of
samples containing paramagnetic ions, such as copper binding proteins
that play an important role in living organisms.
The
new Magic Angle Spinning capability will provide high sensitivity
analysis of micro samples (0.29 ìl), 1/100th of the normal sample
volume, which allows for structural analysis of limited volume samples,
such as natural products and thin films, and analysis of defects and
degradation in localized areas of samples.
Ideal
for structural analysis, the 0.75-mm solid-state NMR probe will include
changes in properties of electrode materials in lithium ion cells after
repeated charge/discharge cycles, and the structural degradation
analysis of thin film materials such as organic EL and organic
transistors, allowing researchers to improve the performance and
durability of these products.
Results
of solid NMR experiments analyzing the same sample using probes of
different spinning speeds show that the signal peak intensities were
significantly higher with the new 110 kHz probe when higher spinning
speeds were used. The data acquired with the new probe were also higher
in resolution, separating peaks more clearly. The new probe will help
acquire detailed information on the types of atoms and the molecular
structure of many substances.
JEOL
Resonance introduced its first new ultra high spinning speed probe in
July 2011, capable of spinning a 1-mm sample tube at an 80 kHz spinning
speed, the fastest at that time.
About NMR and MAS
Nuclear
magnetic resonance (NMR) spectroscopy applies magnetic and RF (radio
frequency) fields to a sample in a magnet. The NMR spectrometer observes
the nuclear magnetic resonance of the atomic nuclei in the sample as it
spins at the magic angle (MA), and is capable of analyzing the
molecular structure of the sample at the atomic level.
Effective
in analyzing organic compounds and high molecular weight polymeric
materials, NMR has a wide range of applications in pharmaceutical,
biology, food, and chemistry. It is increasingly used in new, growing
areas such as organic EL and battery films.
Magic
Angle Spinning (MAS) spins a sample in an NMR magnet at an angle of
54.7° relative to the magnetic field direction. This averages out many
broadening NMR interactions to greatly improve the resolution and
sensitivity of the resulting NMR spectrum.
Source: JEOL Resonance
