Millipore Corp. and CXR Biosciences have launched ToxReporter, a new panel of engineered cell lines and assays that can screen compounds for toxicity early in the drug discovery process.

The ToxReporter panel detects a variety of cellular responses linked to toxic stresses, including:

• Oxidative stress and anti-oxidant response
• Inflammatory response
• Cell cycle control
• DNA damage and apoptosis
• Hypoxia/angiogenesis
• Stress responses

CXR Biosciences developed the novel cell lines exclusively for Millipore as part of a portfolio of innovative in vitro cell-based toxicology assays. Each cell line has been stably transfected with

a common reporter biomarker downstream of response element promoters involved in specific toxicology pathways. The biomarker is expressed by the cells if the specific toxicology pathway is induced and detected in cell culture supernatant using a simple enzyme-linked immunosorbent assay (ELISA).

The ToxReporter product line includes an engineered biomarker cell line, an assay Starter Pack specific for each cell line, and a complete ELISA kit that can be used for each cell line. Additional ToxReporter cell lines are under development, as well as a multiplexed format.

Millipore Corporation and CXR Biosciences