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Scientists create wiring diagram for mouse brain

Thu, 04/03/2014 - 1:08pm
Malcolm Ritter, AP Science Writer
This image provided by the Allen Institute for Brain Science on March 28, 2014 shows a top-down view of connections originating from different cortical areas of the mouse brain. The research published Wednesday, April 2, 2014 is the first brain-wide wiring diagram for a mammal at such a level of detail. While it does not reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected. (AP Photo/Allen Institute for Brain Science)Scientists have created a detailed, three-dimensional wiring diagram of the mouse brain. That should help researchers seek clues about how the human brain works in health and disease.
 
It's the first brain-wide wiring diagram for a mammal at such a level of detail. While it doesn't reveal every connection between each of the rodent's 75 million brain cells, it shows how parts of the brain are connected.
 
The work was described online Wednesday in the journal Nature by Hongkui Zeng and colleagues at the Allen Institute for Brain Science in Seattle.
 
To create the diagram, scientists combined data from more than 1,000 mouse brains, each of which was divided into 140 slices.
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