2014 R&D 100 Winner
Dow AgroSciences' Transform WG Insecticide and Closer SC Insecticide with Isoclast ActiveDow AgroSciences is constantly searching for technological advances for its insecticide products. The company does this by investigating new chemistries that are discovered and rigorously tested using a variety of techniques, such as bioassays. One chemical class which had not been examined extensively as a component for crop protection chemicals is the sulfoximine chemical moietys, which is a chiral, nitrogen-containing sulfur compound. Early discovery-phase sulfoximine insecticides exhibited high levels of aphicidal activity in bioassays. Subsequent improvements in their chemical structure led to improved attributes that culminated in the discovery of Isoclast, the first sulfoximine-class to reach the market. Isoclast, developed by Dow AgroSciences, exhibits interactions with nicotinic acetylcholine receptors (nAChR) in the insects that are distinct from those observed with alternative neonicotinoid insecticides. Cross-resistance in sap-feeding insect strains—which are Isoclast’s primary target—has been lacking because of metabolic differences between Isoclast and other insecticides. This suggests that Isoclast, which has been developed globally and used in crops ranging from cotton to grapes to soybeans, will be an important tool for the management of insect pests that are resistant to other insecticides.


Dow AgroSciences
The Dow Chemical Company

Development Team

The Transform WG Insecticide and Closer SC Insecticide with Isoclast Active Development Team from Dow AgroSciences
Luis E. Gomez, Principal Developer