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2013 R&D 100 Winner
Combined Orthogonal Mobility & Mass Evaluation Technology (CoMet) PlatformThe Combined Orthogonal Mobility & Mass Evaluation Technology (CoMet) platform, developed by Pacific Northwest National Laboratory, addresses the triple challenge of specificity, sensitivity and speed in analyses of complex biological and environmental samples by providing more comprehensive coverage of smaller samples with higher measurement throughput. CoMet integrates two distinctive separations—multiplexed ion mobility spectrometry (IMS) and ultra-fast quadrupole time-of-flight mass spectrometry (Q-TOF MS)—to provide a wealth of information, ultra-sensitive rapid chemical and biological analyses, masses and structures of analytes, separation of samples into chemical and biological classes based on molecular structure and thorough characterization of complex samples. Ion packets separated by IMS are analyzed by a TOF with ~40,000 resolving power and ~3-ppm mass measurement accuracy. A detector quantifies analytes with intensities spanning four orders of magnitude. Ions exiting the drift cell may be collisionally dissociated in the quadrupole without compromising the mobility separation, which enables MS for fragments of mobility-labeled species.

Technology
Combined spectroscopy solution

Developers
Pacific Northwest National Laboratory


Development Team

PNNL CoMet Research Team. Back row (l-r): Alex Shvartsburg, Kevin Crowell, Daniel Orton, William Danielson III, Brian LaMarche, Gordon Anderson, Ronald Moore. Front row (l-r): Keqi Tang, Erin Baker, Yehia Ibrahim, Richard Smith, Gordon Slysz, Randolph Norheim.

 










Matthew Monroe

 







The Combined Orthogonal Mobility & Mass Evaluation Technology (CoMet) platform Development Team from Pacific Northwest National Laboratory
Richard Smith, Principal Developer
Gordon Anderson
Erin Baker
Kevin Crowell
William Danielson III
Yehia Ibrahim
Brian LaMarche
Matthew Monroe
Ronald Moore
Randolph Norheim
Daniel Orton
Alexandre Shvartsburg
Gordon Slysz
Kegi Tang

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