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The Lead

3-D Printing Blasts Off, Explodes Into the Future

February 13, 2015 | by Lindsay Hock, Editor | Comments

In 2013, battle lines were drawn. Two stark competitors were looking to speed repairs and cut costs on parts for gas turbines. First to the drawing board was GE, who started using 3-D printing technology at its Global Research Center in Niskayuna, N.Y., to produce more than 85,000 fuel nozzles for its anticipated LEAP engine technology.

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R&D Daily

The Difference Between Research and Development

February 24, 2015 9:34 am | by Bradford L. Goldense, President, Goldense Group Inc., Needham, Mass. | Comments

The already unclear lines separating research from development are getting even blurrier as more companies allocate some part of their R&D budget to take on riskier projects, and invest in the necessary infrastructure to manage these riskier activities. New products are now being launched out of recently formed "Innovation" organizations", and more are coming from existing “Advanced Development" organizations.

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Innovations in Cell Culture Technology Drive Drug Discovery Studies

February 24, 2015 9:14 am | by Cindy Neeley, PhD, Field Applications Scientist, Thermo Fisher Scientific, Labware & Specialty Plastics, Rochester, N.Y. | Thermo Fisher Scientific | Comments

Scientists around the world make use of cell culture techniques on a daily basis. Whether they happen to be working with primary cell cultures, secondary cultures or cell lines, they all face many of the same problems: slow growth, spontaneous differentiation, evaporation, contamination and a host of other issues that require troubleshooting.

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Computational Model Reveals the Importance of Transitional Dynamics of “Memory Molecule” in Memory Formation

February 24, 2015 9:01 am | by Glen C. Rains | Comments

The dynamics of a molecule abundant in the synapse, Ca2+/Calmodulin dependent kinase type II (CaMKII), known as the “memory molecule”, are important in memory formation. Synapses are junctions connecting neurons and there’s increasing evidence they store memory when neurons are stimulated by the environment.

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EMI Compliance: Choosing the Right Shielding and Gasketing

February 23, 2015 10:28 am | by Ed Nakauchi, Technical Consultant, Orbel Corporation | Comments

Compliance to EMI regulations is essential in today’s global market and applies to almost any electronic/electrical device. Also, almost every country in the world now requires meeting not just EMI emissions standards, but also immunity requirements.

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Sustaining a Laboratory Environment

February 13, 2015 1:00 pm | by Lindsay Hock, Editor | Comments

The design of laboratories for sustainable construction and operation has become a major driver in the A/E/C industry over the past 10 to 15 years. Most large academic, government and corporate laboratory clients are looking for sustainable design approaches at a minimum, and third-party certification, such as LEED, in many cases.

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Superior Resolution for the Biological World

February 13, 2015 12:47 pm | by Lindsay Hock, Editor | Comments

Traditional fluorescence microscopy has suffered from the resolution limits imposed by diffraction and the finite wavelength of light. Classical resolution is typically limited to about 200 nm in xy. Due to the nanoscale architecture of many biological structures, researchers developed super-resolution techniques, starting in the 1990s, to overcome this classical resolution limit in light microscopy.

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Limitless Photovoltaic Future

February 13, 2015 12:27 pm | by Tim Studt, Editor-in-Chief | Comments

Researchers working with photovoltaic (PV) technologies and production processes have made great strides over the past several years, such that PV systems are now considered a viable and cost-competitive energy alternative to traditional fossil fuel energy sources. The number of installations continues to increase, while panel and system costs continue to decline.

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Giving Design Power to Everyone

February 13, 2015 12:01 pm | by Tim Studt, Editor-in-Chief | Comments

Multiphysics software has become the simulation tool for designing and optimizing new products. This software can quickly provide designers with multiple options for critical product designs across a range of environmental, physical and chemical operating conditions. Recently introduced multiphysics software enhancements also allow simplified use of these simulation tools across a broader range of users.

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Six Tips to Use When Calibrating Your pH Meter

February 13, 2015 11:50 am | by Hanna Instruments | Comments

Reliable pH measurements are essential to a variety of processes and industries. From agriculture, to wastewater and plating, to food processing, measuring pH is a crucial step in determining the efficiency of a process or quality of a product. Vital steps in achieving accurate pH results include calibrating a pH meter and ensuring the electrode is working properly.

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Advances in PCR Improve Health of Animal Research Colonies

January 22, 2015 3:59 pm | by Ken Henderson, Director of R&D, Charles River Laboratories, Wilmington, Mass. | Comments

Reducing the use of laboratory animals has been a long-term goal in biological research. Many in vivo assays, like rabbit endotoxin testing or mouse antibody production testing to detect viral contaminants have largely been replaced by in vitro enzyme or PCR-based assays.

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Microfluidic Method for Primary Neuron Culture and Analysis

January 7, 2015 8:42 am | by Paul J. Hung, Shin-Yi Cindy Chen, Ivana Zubonja and Terry A. Gaige, EMD Millipore | Comments

Dissecting neuron function, while crucially important for understanding normal and pathological neurological processes, requires measuring the responses of live cells to external stimuli. Because of the inherent difficulties in performing perturbation analyses inside living organisms, there has been a longstanding drive towards developing methodologies for in vitro analysis of neurons.

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Optimizing Industrial Drying Systems Using CFD

January 7, 2015 8:30 am | by Mehul Patel, CFD Consultant, HiTechCFD | Comments

Industrial drying systems are most commonly used in process industries to remove moisture content from the materials. These systems are designed according to the required moisture removal requirement. The working principle of drying systems is purely based on evaporation of liquids from solids.

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A Clear Vision

December 17, 2014 9:29 am | by Paul Livingstone | Comments

Around 400 BC, Hippocrates was among the first people in recorded history to postulate the brain as the seat of sensation and intelligence. Yet only in the last 100 years have we identified, and closely studied, its key building block: the neuron. A highly specialized cell found in all but the simplest animals, like sponges, the neuron is one of the keys to understanding the brain.

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Multidisciplinary and Collaborative R&D

December 17, 2014 9:00 am | by Tim Studt | Comments

Every year, in conjunction with the R&D 100 Awards Banquet, R&D Magazine’s editors convene a panel of R&D leaders to discuss the current issues confronting their organization’s R&D programs, staff and administration. This year’s panel was held on November 7, 2014, at the Bellagio, Las Vegas, Nev., and included three R&D managers from industry and one each from government and academic organizations.

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A Zero-Net-Energy Teaching Laboratory

December 16, 2014 2:01 pm | by Jacob Knowles, LEED AP, Director of Sustainable Design, BR+A Consulting Engineers and James Moses, AIA, LEED AP, Director, Sasaki Associates | Comments

The 50,000-sf New Technology and Learning Center for Bristol Community College, Fall River, Mass., brings together disparate programs—chemistry, biology, medical and dental education—holding energy-dense uses, including 18 fume hoods, high plug loads and specific ventilation and lighting requirements.

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