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To avoid lung disease complications, scientists and engineers at Los Alamos National Laboratory have developed PuLMo: Pulmonary Lung Model—a miniature, tissue-engineered lung platform that precisely mimics the response of human lungs to pharmaceuticals and other agents. The principal application of PuLMo, a winner of a 2016 R&D 100 award, is to revolutionize the reliability of drug toxicity assessments and better predict the efficacy of a new drug in humans. Since PuLMo is the size of an actual human lung, such miniaturization makes it possible to evaluate multiple units at a time.

Customization of integrated components could also create models for different lung-specific diseases and conditions. Another application is using PuLMo as a platform from which to study the flow dynamics of particles inside a lung. These flow dynamics are essential in many research and development applications, including drug delivery, smoke and e-cigarette inhalation studies, as well as particle/pathogen deposition studies.

Each year for more than 50 years, R&D Magazine has honored the 100 best innovations in research and development. We are currently accepting applications for the 2017 R&D 100 Awards. Innovators with an exceptional product developed between January 1, 2016 and March 31, 2017 should apply. Submissions close April 14, 2017

For information on the 55th Annual R&D 100 Awards and to enter visit http://www.rd100conference.com

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