Spectrum Laboratories, Inc. introduced the KrosFlo Research
IIi tangential flow filtration (TFF) system. This updated system—suited for
R&D scale microfiltration and ultra-filtration processing—comes with the digital
pressure monitor integrated into the peristaltic pump. Both the pump and
pressure monitor functions are controlled by the same PLC/HMI. While the pump
head handles the same flow rates as the previous version, from 0.01 ml/min to
2.3 LPM, the unit now has a smaller footprint on the bench.
The digital pressure monitor has a digital LCD display with
LED backlight. Four pressure measurements are displayed including: feed, retentate,
permeate, and transmembrane pressure. The system has both audible and visual
low- and high- pressure alarms for the inlet and permeate, and a high-pressure
pump shutoff that helps maintain membrane integrity and achieve high product
recovery.
The KFComm Data Collection Software included with the system
interfaces with a computer to download real-time process data to an Excel file.
The information captured includes pressures and flow rates. The software also
calculates and trends transmembrane pressure, filtration flux, shear, volumetric
throughput, and the concentration factor.
When operated with single-use filters and flow paths the
system can concentrate and diafilter process solutions while avoiding cross
contamination. The automatic backpressure valve accessory can be used to
maintain process pressures without fluid contact.
The filtration system when used with Spectrum’s hollow fiber
filters provides faster and gentler separation of proteins, cells, viruses,
nanoparticles, and other macromolecules.
Spectrum
Laboratories, Inc., www.spectrumlabs.com
