Caliper Life Sciences, Inc. introduced the IVIS Lumina XR in vivo imaging system, the latest addition to the IVIS product family. The Lumina XR system combines sensitive bioluminescence and fluorescence molecular optical imaging with the anatomical precision of digital x-ray. Integrating these three imaging modalities provides researchers with additional capabilities to explore the molecular basis of disease and determine the response to drug therapies.
Caliper's non-invasive IVIS preclinical molecular optical imaging technology is an innovative research tool that has advanced both basic scientific research, as well as the novel breakthrough research necessary to develop safe new drugs. To date, peer-reviewed publications show that IVIS technology has aided the discovery and development of five FDA-approved therapies and more than nine drug compounds in development. The introduction of the Lumina XR system takes this innovation one step further by combining optical fluorescent and bioluminescent images of biological activity with co-registered digital x-ray images, enhancing the anatomical context of the optical molecular signals. For example, with x-ray co-registration the researcher can view a detailed image of the skeleton, or even certain soft tissues, and can use those images as a reference point when using bioluminescence to more precisely locate a tumor or infection site in an animal.
All IVIS systems are optically capable of imaging the full spectrum of fluorescent and bioluminescent reporters and dyes, from green to near-infrared, with quantitative results and high performance spectral unmixing, to extract maximum information from animal models. Lumina XR can incorporate the premium animal handling features of Caliper's other IVIS imaging systems, such as a heated stage, gas anesthesia connections and a syringe injection system for simultaneous compound administration. In addition to mice, the Lumina XR can accommodate Petri dishes or micro-titer plates for in vitro imaging. And, like Caliper's other IVIS imaging systems, the Lumina XR will serve a broad array of therapeutic areas, including cancer research, infectious disease, inflammation, metabolic disease, neurology, cardiovascular disease, toxicology, and other applications.
For additional information on Caliper's portfolio of optical imaging systems, please visit http://www.caliperls.com/products/optical-imaging .
Caliper Life Sciences, www.caliperLS.com
