Genomes for sale—your own

Nov. 20, 2007
According to DNA sequencing and bioinformatics specialists GATC Biotech, Hamburg, Germany, they are the first sequencing company worldwide to offer whole human genome sequencing to industry and academia.

With the just-launched service, GATC hopes to boost the move towards personalized medicine by sequencing up to 100 genomes by the end of 2010. They will meet this ambitious target by forming collaborative partnerships with leading world-class research institutes and pharmaceutical, pharmacogenomics and diagnostics companies.

The announcement, made at a press conference at the recent BIO-Europe 2007, the world’s largest biotechnology industry networking event, comes at a time when the U.S. Federal Drug Administration has just recommended that clinicians obtain patients’ genetic profiles before prescribing warfarin. The FDA is promoting personalized medicine as part of its ‘Critical Path Initiative’ to encourage innovation in drug development.

Improved access to genomic data could transform the diagnosis and treatment of cancer, according to Prof. Christof von Kalle from the German National Center for Tumor Diseases.

“By sequencing and comparing genomes obtained before and after the diagnosis of cancer, researchers can gain a better understanding of the genetic basis of cancer, particularly the role of the previously understudied non-coding regions. There is growing evidence implicating these areas, which comprise 98.5% of the human genome, in the onset and control of cancer,” says von Kalle.

Peter Pohl, CEO of GATC, says his company will build the capacity and expertise to initiate and deliver this visionary, but tough, project. GATC has about two decades of DNA sequencing expertise, having sequenced close to 100 microbial genomes since 1990, and uses four leading high-throughput sequencing technologies.

The first human genome sequenced cost $3 billion; this cost has now fallen to about $5 million. GATC plans to bring down the cost of human genome sequencing further and to provide a clearer picture of the human genome by using next-generation sequencing and high-end bioinformatic technologies. Their visionary aim is to deliver, in ten years, a quality dataset for 500 Euros, making it a realistic option for pharmaceutical research.

SOURCE: GATC Biotech