Somewhere deep inside U2’s late 1980s album Rattle & Hum a preaching Bono apologizes to the crowd for lecturing them on the evils of apartheid. “Am I buggin’ you? Don’t mean ta bug ya. Okay, Edge, play the blues.”

In a welcome change for the next album, Bono became “The Fly”.

No worries, Bono. At least you are a not a bed bug. Supposedly, 1 in 15 people in America’s largest city, New York, have had to deal with the microscopic pests, which are enjoying a renaissance of sorts. They have claimed the couches and bedding of tens of thousands of people in the NYC area, and are spreading throughout the country. Perhaps they are attracted to all the jobs?

Not likely. They’re just moving back after a long vacation. Remember DDT? Swiss chemist Paul Hermann Müller was given a Nobel prize in 1948 for figuring out that dichlorodiphenyltrichloroethane was good for killing arthropods. First synthesized in the 19th century, it and another chemical, chlordane, were largely responsible for kicking the bugs out of bed for good.

In 1962, Rachel Carson released her book Silent Spring. She was to pesticides what Ralph Nader was to cars. Both DDT and chlordane were swiftly removed from use after it was shown to directly harm bird populations as the chemical had the side-effect of thinning eggshells. The likely clincher for its ban in 1972 was the decline in bald eagle populations. Further research suggested that organochlorine compounds, which are toxins, can have potentially serious health effects to humans, possibly causing cancer, diabetes, and endocrine disruption.

Unfortunately, because bed bugs feed on blood and aren’t attracted to bait, they are extremely difficult to eradicate. They can jump aboard clothing or luggage and hitch a ride across town, or across the ocean. The proliferation of international air travel has helped spread them throughout the U.S., and over time bed bugs have also evolved: New York City bugs are 264 times as resistant to a common treatment, deltramethran, than the bugs in, say, Florida.

Before DDT, bed bugs were common throughout the U.S. It’s part of their natural habitat. Aside from some icky bleeding and itchy bites, bed bugs don’t often cause serious disease. But there’s another parasite that hasn’t yet returned to it’s native habitat that does. Malaria is making its own long comeback after being nearly wiped out after World War II. The same DDT that knocked down bed bugs also went a long way to eradicating the parasites that now kill and plague millions in Africa, Asia, and elsewhere with a laundry list of suffering that includes fever, shivering, joint pain, vomiting convulsions, brain damage, vomiting, and anemia.

It was rampant in the U.S., and helps explain why people were fond of vacating Washington, D.C. in the summer because of the heat and the malarial waters of the Potomac.

Wetland draining and vast improvements in sanitation helped tamp down malaria as much as DDT did in many parts of the country. But DDT was largely the reason for the disappearance of malaria in the South by 1951.

Even in Africa, sanitation and containment efforts were working in the early 20th century. Now, the continent is stumbling backward and only investment from outside is keeping casualties down. Treatment has gotten better as drugs containing ancient anti-malarial compounds are administered more effectively. These include the herb Artemisia and quinine (British colonists liked their gin-and-tonics for a good reason). Artemisinin alone can sweep the body clear of malaria, but concern about the potential catastrophe from malaria building resistance to this chemical has prompted the use of partner drugs that finish the treatment started by artemisinin-based compounds.

Experts are worried for good reason. Chloroquine and sulfadoxine-pyrimethamine are no longer effective on common malarial parasites, and in 2009, researchers published the first distinct evidence that malaria is becoming more resistant to the most common treatment: artesunate, which is derived from artemisinin, and mefloquine, a quinine analogue. Their findings, centered on lengthening treatment timelines in Southeast Asia, could spell disaster if resistant strains make their way to Africa.

Worse, we still don’t know how artemisinin works, which complicates efforts to modify the chemical and stay ahead of malarial mutation.

The most unfortunate thing, however, is that when properly used, DDT is effective against malaria. It caused such havoc in the 1950s because, in addition to government use to control disease vectors, farmers were indiscriminately using tremendous amounts of the toxin for agricultural pest control. DDT is apparently still used for agriculture in North Korea, and about 5,000 tons are still legally used worldwide to help control mosquito populations.

Alternative methods should still be aggressively pursued, however. DDT and other organochlorine compounds are still harmful to the environment and because they are hydrophobic, can last up to 30 years. This insolubility means they are prone to concentrating throughout the food chain, showing up on top tier predators.

As our genetic expertise improves, we will someday be able to attack the core of Plasmodium strains and control malaria at the source. Until then, we'll either have to invent a better DDT or simply grin and bear the incursion of the bed bugs. Harmless, they may be, but few critters bug me as much these nasty little things.

Predictably, The Fly is now buggin’ us about malaria. But it’s only a matter of time before bed bugs bug him, too.