2010 R&D 100 Winner
Drug discovery researchers turn to supercritical fluid chromatography (SFC) for its separation speed, low energy demands, and use of CO2 for the mobile phase. However, poor UV and MS baseline noise performance have relegated SFC systems to screening applications.
The SFC Fusion A5 module from Aurora SFC Systems, Inc., Toughkenamon, Pa., is an accessory module for an existing high performance liquid chromatography (HPLC) system that operates in the 100 to 400 bar pressure range. By preconditioning the CO2 supplied to the HPLC system and regulating the backpressure against which the system delivers its output, the module allows the original HPLC pumping system to pump liquid CO2 with the same noise performance as water. An HPLC system with the SFC Fusion A5 module can function as effectively as an SFC system.
The original HPLC system remains intact with its original control system and can be disconnected from the SFC Fusion A5 module as needed.
Technology
SFC module
Developer
Aurora SFC Systems, Inc.
Development Team
The SFC Fusion A5 Development Team from Aurora SFC Systems, Inc.:
Terry Berger
Michael Casale
Samuel O.Colgate
Kimber Fogelman
Edwin Wikfors
.
