Wednesday, September 24, 2008
2008 R&D 100 Winner
Nuclear magnetic resonance (NMR) spectrometry is one of the most important experimental techniques to obtain physical, chemical, electronic, and structural information from molecules. Conventional room-temperature NMR microprobes with 5-µL and 30-µL volumes have become popular in areas such as natural products chemistry, drug metabolism, protein NMR, and drug screening applications. Researchers working with very limited sample quantities in this area will benefit greatly from the 600 MHz 1.7 mm TCI Micro-CryoProbe with Z-Gradient from Bruker BioSpin AG, Fällanden, Switzerland. The Micro-CryoProbe offers an increase in mass sensitivity of more than an order of magnitude over conventional NMR probes, which is achieved by cryogenically cooling both the detection coil and preamplifier and the addition of high-sensitivity electronics. It is three to five times more sensitive and achieves a 400-fold reduction in experimental time compared to standard room-temperature probe technology. In addition, for small molecule applications, the limit of detection is in the nanogram range.
Technology
NMR microprobe
Developer
Bruker BioSpin AG
